Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action

Seckin, Serin; Ramadan, Hadi; Mouanness, Marco; Kohansieh, Michelle; Merhi, Zaher

doi:10.1007/s10815-021-02385-w

Cited by 28 publications

(20 citation statements)

References 45 publications

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“…The intraovarian injection of PRP can assist in the improvement of ovarian function in women with POR, POI or at perimenopause and menopause stages [ 32 , 33 , 34 , 35 ]. One of the main challenges of reproductive medicine is to rejuvenate ovarian function to increase the number of released follicles [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…From those, a total of 253 women finally met the inclusion criteria and enrolled in the study. To date, this is the first study that includes a great number of participants, compared to previously conducted studies worldwide [ 32 , 33 , 34 , 35 ]. Based on the ovarian dysfunction type and in correlation with the average age, participants were divided into five groups.…”

Section: Discussionmentioning

confidence: 99%

“…In the past, endometrial infusion of PRP resulted in proper management of chronic endometriosis [ 30 , 31 ]. Nowadays, the utilization of PRP-derived growth factors has been reported in an attempt to restore ovarian function in women suffering from POR, POI or at perimenopause and menopause stage [ 32 , 33 , 34 , 35 ]. The majority of the studies utilizing the autologous PRP for ovarian rejuvenation present encouraging results, still the intraovarian injection of PRP must be further evaluated, to assure safer conclusions.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study

et al. 2023

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Background: The intraovarian administration of autologous platelet-rich plasma (PRP) acts beneficially for the stimulation of follicle production in women presenting different forms of ovarian dysfunction. This pilot study aimed to evaluate and provide significant data regarding the efficacy of PRP to rejuvenate the ovaries. Methods: A total of 253 women aged 22–56 years, were divided into five groups, based on their status. All participants signed for informed consent for the current study. Blood sampling, preparation of PRP and intraovarian infusion of the latter were performed on all participants. The evaluation of PRP efficacy, a two-month follow-up detecting the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-mullerian hormone (AMH), was performed for all participants. For women with advanced ages (>48 years), the restoration and regularity of the menstrual cycle were additionally evaluated. Results: After the two-month follow-up, the majority of the participants presented improvement in their hormonal profiles. Additionally, 17% of the women in this pilot study successfully conceived. The restoration of the menstrual cycle was detected in 15% of the women with advanced ages. Conclusions: Intraovarian infusion of autologous PRP exhibited remarkable evidence and promising results to restore ovarian insufficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study

et al. 2023

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“…The PRP from L-GF equina , through its high cytokines and growth factors, could stimulate angiogenesis and then ovarian perfusion, as well as improving the oocyte’s competence in humans [ 34 ]. In humans, it was observed that an in vitro culture of primordial follicles in the presence of PRP significantly increased follicular growth and viability when compared with a control culture [ 35 ]. Growth factor ligands interact with receptors after intraovarian injection of PRP to affect cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

Intraovarian Injection of Reconstituted Lyophilized Growth-Promoting Factor Extracted from Horse Blood Platelets (L-GFequina) Increases Oocytes Recovery and In Vitro Embryo Production in Holstein Cows

Silviu‐Ionuț¹,

Dascălu²,

Borş

et al. 2022

Animals

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The purpose of this study was to determine the impact of intraovarian injections of a reconstituted lyophilized growth-promoting factor extracted from horse blood platelets (L-GFequina) on the number of ovarian follicles, the recovery of cumulus–oocyte complexes (COCs), and embryo development to the blastocyst stage in Holstein cows. Thus, 12 Holstein cows were assigned to three protocols. According to the number of punctured follicles in protocol 1, ovum pick-up (OPU) was conducted on days 6 and 14 of the cycle (day 0 = estrus). In protocol 2, every large follicle (more than 7 mm) was removed, and 1 mL of L-GFequina was intraovarian injected (day 0). Two days later, equine chorionic gonadotropin (eCG) was administered, and OPU sessions were conducted on days 6, 10, and 14. The same ovarian stimulation procedure as that in protocol 2 was performed in protocol 3, except that equine L-GFequina was not supplied. OPU was carried out on days 6 and 10 of the cycle. The results indicate that the intraovarian injection of L-GFequina significantly (p < 0.05) increased the number of OPU sessions per cycle, the recovery of cumulus–oocyte complexes (COCs), and the production of blastocysts. In conclusion, an intraovarian injection of L-GFequina can improves OPU-IVEP results in Holstein cows.

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“…[13]. If the potential of PRP is utilized, then women who suffer from premature ovarian insufficiencies, poor ovarian reserve, and even early menopause cases where they are trying to conceive using their own oocytes may find this helpful [14].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Plasma: A Promising Regenerative Therapy in Gynecological Disorders

Varghese¹,

Acharya²

2022

Cureus

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Platelet-rich plasma (PRP) could be understood as a special preparation of plasma in which the concentration of platelet is immensely high. This rationale for plasma use has been in the medical science for many years with plenty of success in various fields where it was inculcated, bringing dramatically favorable and better outcomes in terms of disease management and prognosis. PRP has been widely used in orthopedics from the very beginning, but in the past few years its use has been extended to other fields too, such as obstetrics and gynecology. From the very onset of the introduction of platelet-rich plasma in gynecology, there had been constant research being carried out all around the globe in order to scientifically prove and confirm its exact role in the management of gynecological problems. Regenerative medicine in gynecology was among the first areas where the platelet-rich plasma was implemented and has substantially given great results, which encouraged further extensive research to be carried out in other spectrums of gynecology. The implications of such great struggles ultimately gave way to evidence suggesting the importance of platelet-rich plasma in managing gynecological disorders like Asherman's syndrome, urinary incontinence, genital fistulas, thin endometrium, etc. This review article collectively summarizes the various use of platelet-rich plasma in gynecology.

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Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action

Cited by 28 publications

References 45 publications

Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study

Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study

Intraovarian Injection of Reconstituted Lyophilized Growth-Promoting Factor Extracted from Horse Blood Platelets (L-GFequina) Increases Oocytes Recovery and In Vitro Embryo Production in Holstein Cows

Platelet-Rich Plasma: A Promising Regenerative Therapy in Gynecological Disorders

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