Ovarian sarcoma

Anderson, Barrie; Turner, Deborah; Benda, Jo Ann

doi:10.1016/0090-8258(87)90272-1

Cited by 51 publications

(39 citation statements)

References 16 publications

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“…In addition to high cellularity, moderate to severe cytologic atypia, and increased mitotic activity, fibrosarcomas may exhibit atypical mitotic figures and tumor cell necrosis. 9,10 These tumors are the most common sarcomas of the ovary and occur most commonly in older women, although women of any age may be affected.…”

Section: Fibrosarcomamentioning

confidence: 99%

Ovarian Stromal Tumors

Ioffe¹

2006

Pathology Case Reviews

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Ovarian stromal tumors range from fibroma to thecoma, depending on the degree of luteinization of tumor cells. They occur in peri-and postmenopausal women and are most commonly unilateral. The mitotic rate is the main feature helping predict the behavior of these tumors: while usual fibromas and thecomas are virtually amitotic, mitotic rate of 4 or more mitotic figures per 10 high-power fields is used as a cutoff to diagnose a fibrosarcoma. Fibrosarcomas, in addition to an increased mitotic rate, are also hypercellular and exhibit significant cytologic atypia; some may show tumor cell necrosis and could be adherent to adjacent pelvic organs, causing difficulty at surgery. Fibrosarcomas pursue a malignant clinical course, with local recurrence and metastases, usually to the lungs. Tumors with increased cellularity and mitotic counts of 3 or fewer mitoses per 10 high-power fields are termed cellular fibromas and have a somewhat increased likelihood of local recurrence after a long period of time, especially if they were adherent to pelvic organs or were ruptured at surgery. Ovarian stromal tumors may present a diagnostic difficulty when they undergo torsion with infarction and cystic change, which may render their histologic recognition problematic. Thorough sampling, along with immunohistochemistry for ␣-inhibin and calretinin, may help in making the correct diagnosis. Fibromas may be associated with several clinical and genetic syndromes, most notably Meigs syndrome, consisting of ascites and pleural effusions which resolve after tumor removal, and a hereditary Gorlin syndrome, consisting of multiple basal cell carcinomas, cysts of the jaw, and other neoplasms, including ovarian fibromas.

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Section: Fibrosarcomamentioning

confidence: 99%

Ovarian Stromal Tumors

Ioffe¹

2006

Pathology Case Reviews

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“…Primary ovarian smooth muscle tumors are very rare tumors in comparison with the uterine smooth muscle tumors (1). There is little information on their origin, etiology, histological features, clinical behavior, and treatment (5).…”

Section: Discussionmentioning

confidence: 99%

“…A huge ovarian smooth muscle tumor : a case report Masahiro Murakami 1) , Hisanori Uehara 2) , Masato Nishimura 3) , Takeshi Iwasa 3) , and Hiroshi Ikawa 1)…”

Section: Case Reportmentioning

confidence: 99%

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A huge ovarian smooth muscle tumor: a case report

Murakami¹,

Uehara

Nishimura

et al. 2010

J. Med. Invest.

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“…Primary leiomyosarcoma of the ovary is an extremely rare subset of ovarian sarcomas, which make up less than 1% of all ovarian malignancies [1]. Fewer than 30 cases of primary leiomyosarcoma of the ovary are reported in the literature [2].…”

Section: Introductionmentioning

confidence: 98%