Ovarian serous surface papillary borderline tumor: characteristic imaging features with clinicopathological correlation

Park, Sung Bin; Kim, Minjeong; Lee, Kyung Ho; Ko, Yousun

doi:10.1259/bjr.20170689

Cited by 14 publications

(7 citation statements)

References 17 publications

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“…Several pathologic studies have reported ovarian surface growth in borderline tumors, and a few sonographic studies addressed this issue 10,15 . However, our study was the first to describe the sonographic features, which allows for the differentiation between ESBOT and HGSC.…”

Section: Discussionmentioning

confidence: 86%

“…While exophytic growth of serous BOT on the surface of the adnexa is rare, it is a prominent feature of invasive ovarian cancer on ultrasound examination and its presence can cause diagnostic confusion. ESBOTs were reported in a few imaging studies, 10,15 but mainly reported in histopathologic examinations. In this study, we characterized different sonographic features that can differentiate between ESBOT and HGSC.…”

Section: Discussionmentioning

confidence: 99%

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A New Insight on Exophytic Serous Borderline Adnexal Tumors: Specific Sonographic Features

Haddad

Kugelman

Shapiro

et al. 2021

J of Ultrasound Medicine

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Objectives-To characterize and compare the sonographic features of exophytic serous borderline ovarian tumors (ESBOT) with those of high-grade serous carcinoma of the ovary (HGSC).Methods-Seven patients with histological diagnosis of ESBOT diagnosed between 2011 and 2019 and 10 consecutive cases of HGSC detected during 2019, both depicting an exophytic growth pattern, were identified retrospectively. The sonographic imaging of the masses was reassessed and characterized according to the International Ovarian Tumor Analysis terms.Results-A unilateral irregular solid adnexal mass was demonstrated in all patients with ESBOT. The mass typically wrapped an apparently normal ovary, with a clear demarcation line depicted between them and it contained tiny cystic inclusions and calcifications. On color Doppler study of all the ESBOT cases, a unique vascular pattern could be demonstrated: an intratumoral vascular bundle originating from the ovarian vessels and supplying a rich radial blood flow to the tumor periphery. These characteristic morphological and color Doppler features could not be observed in any of the HGSC cases (P < .001). In 42.8% of the patients with ESBOT, additional unilocular-solid components (ipsilateral or contralateral) could be detected, whereas all the HGSC patients presented with a multilocular-solid tumor morphology (P < .001). The interface of the external mass border with the adjacent pelvic walls was regular in all the cases with ESBOT, whereas in 80% of HGSC patients, it was irregular, suggesting invasiveness (P = .002).Conclusions-ESBOT can mimic HGSC. Our results suggest that ESBOT has specific B-mode and color Doppler features, enabling differentiation from HGSC and planning appropriate intervention.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

A New Insight on Exophytic Serous Borderline Adnexal Tumors: Specific Sonographic Features

Haddad

Kugelman

Shapiro

et al. 2021

J of Ultrasound Medicine

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“…Generally, histologically identified rats’ SBOTs have similar MRI morphological subtypes to those of humans, which is also divided into four subtypes: unilocular cysts with papillary projections, minimally septate cysts with papillary projections, markedly septate cysts (over five septa) with plaque-like excrescences and predominantly solid lesions with exophytic papillary projections [1, 7, 25]. As we know, micropapillary projection was a characteristic of SBOTs, which had been reported in previous researches [5, 8, 15, 23]. This architecture was also found in the rat SBOT model.…”

Section: Discussionmentioning

confidence: 67%

A rat model of serous borderline ovarian tumors induced by 7,12-dimethylbenz[a]anthracene

Cai

Liu

et al. 2019

Exp. Anim.

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Serous borderline ovarian tumors (SBOTs) behave between benign cystadenomas and carcinomas, and the effective detection and clinical management of SBOTs remain clinical challenges. Because it is difficult to isolate and enrich borderline tumor cells, a borderline animal model is in need. 7,12-dimethylbenz[a]anthracene (DMBA) is capable of inducing the initiation, promotion, and progression of serous ovarian tumors. This study aims to investigate the proper dosage and induction time of DMBA for rat models of SBOTs, and explore their morphological features demonstrated by magnetic resonance (MR) imaging and molecular genetic characteristics. Rats were randomly divided into six groups (1 mg/70 D, 2 mg/70 D, 3 mg/70 D, 2 mg/50 D, 2 mg/90 D, and 2 mg/110 D). The 3 mg/70 D group induced the most SBOTs (50.0%, 12/24). The micropapillary projections were shown on MR imaging, which was the characteristic of SBOTs. The Cyclin D1 characterizing an early pathogenetic event strongly expressed in induced serous benign tumors (SBTs). The immunoreactivity staining scores of P53 expression significantly increased from SBTs, SBOTs to serous ovarian carcinomas (SCAs), which elucidate that P53 might be a promising biomarker to grade serous ovarian tumors. Based on morphological and molecular genetic similarities, this rodent SBOT model was suitable for investigating the pathogenesis of serous ovarian tumors and developing an early detection strategy.

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“…Notably, serous BOT displaying a micropapillary pattern without implants (stage I) or with non-invasive implants (stage II and III) could have the same prognosis as serous BOT without a micropapillary pattern ( 69 ).…”

Section: Disease Recurrencementioning

confidence: 99%

The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age

et al. 2022

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Borderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conservative surgical management (fertility-sparing treatment) is thus becoming of paramount importance. At early stages, the modalities of conservative treatment could range from mono-lateral cystectomy to bilateral salpingo-oophorectomy. Although cystectomy is the preferred method to promote fertility it can lead to an elevated risk of recurrence; therefore, an appropriate counseling about the risk of relapse is mandatory before opting for this treatment. Nevertheless, relapses are often benign and can be treated by repeated conservative surgery. Besides the stage of the disease, histological subtype is another essential factor when considering the proper procedure: as most mucinous BOTs (mBOTs) are more commonly unilateral, the risk of an invasive recurrence seems to be higher, compared to serous histotype, therefore unilateral salpingo-oophorectomy is recommended. In the appraisal of current literature, this review aims to gain better insight on the current recommendations to identify the right balance between an accurate staging and an optimal fertility outcome.

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Ovarian serous surface papillary borderline tumor: characteristic imaging features with clinicopathological correlation

Cited by 14 publications

References 17 publications

A New Insight on Exophytic Serous Borderline Adnexal Tumors: Specific Sonographic Features

A New Insight on Exophytic Serous Borderline Adnexal Tumors: Specific Sonographic Features

A rat model of serous borderline ovarian tumors induced by 7,12-dimethylbenz[a]anthracene

The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age

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