Ovarian steroid cell tumor, not otherwise specified: A clinicopathological and immunohistochemical experience of 12 cases

Haroon, Saroona; Idrees, Romana; Fatima, Saira; Memon, Aisha; Kayani, Naila

doi:10.1111/jog.12537

Cited by 18 publications

(19 citation statements)

References 30 publications

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“…However, of the 5 patients who did not receive any adjuvant therapy, all experienced recurrence [10,13,15,16] . This shows that chemotherapy is at least somewhat effective, especially when used as postsurgical adjuvant treatment in relatively early-stage disease, a category that includes our patient [9,16] . For advanced or recurrent disease, the clinical significance of chemotherapy is uncertain [10,12,14] .…”

Section: Discussionmentioning

confidence: 99%

“…The chemotherapy regimen and outcome were not available for 1 patient [11] . Of the remaining 5, including ours, 2 experienced recurrence, and 3 are alive without recurrence [9,12,14,16] . However, of the 5 patients who did not receive any adjuvant therapy, all experienced recurrence [10,13,15,16] .…”

Section: Discussionmentioning

confidence: 99%

“…Of the remaining 5, including ours, 2 experienced recurrence, and 3 are alive without recurrence [9,12,14,16] . However, of the 5 patients who did not receive any adjuvant therapy, all experienced recurrence [10,13,15,16] . This shows that chemotherapy is at least somewhat effective, especially when used as postsurgical adjuvant treatment in relatively early-stage disease, a category that includes our patient [9,16] .…”

Section: Discussionmentioning

confidence: 99%

“…The review by Hayes and Scully [1] was published in 1987 and, since then, there have been no review articles or large case series on malignant SCTs, only case reports. Therefore, we reviewed the relatively recent literature (published since 1998) concerning malignant SCTs, in order to reevaluate the effectiveness of postsurgical adjuvant therapy and the clinical outcome in each patient [6,9,[10][11][12][13][14][15][16] . The clinicopathological factors, adjuvant therapies used, and outcomes in 12 reported patients, including the case in this study, are described in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

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Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Kosaka¹,

Hasegawa²,

Kiuchi³

et al. 2017

Acta Cytologica

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Background: Ovarian steroid cell tumors (SCTs) are rare and usually benign, although 25-43% are reportedly malignant. The cytologic findings of these rare ovarian tumors have almost never been reported. Case: We report a rare case of a malignant ovarian SCT with peritoneal dissemination and malignant ascites in a 40-year-old woman. Her tumor was classified as stage IIB (pT2bNoM0) according to the FIGO (International Federation of Gynecology and Obstetrics) classification system, and she was treated with adjuvant chemotherapy following staging laparotomy. Cytology of the ascitic fluid revealed large, polygonal-to-round cells and multinucleated cells with atypia, appearing in clusters with slight overlapping or as isolated tumor cells. Numerous tumor cells had small central round or eccentric nuclei with conspicuous nucleoli, and a moderate-to-abundant amount of cytoplasm, varying from granular and eosinophilic to pale and multivacuolated (foamy), with cannibalism formations. The nuclear chromatin was fine and granular, with irregular distribution and nuclear-membrane thickening. Conclusion: These may be the first reported cytology results for ascites with a malignant SCT. Our patient's cytological ascitic findings, rather than the histopathologic features of the original and disseminated tumors, represent the malignant features of the tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Kosaka¹,

Hasegawa²,

Kiuchi³

et al. 2017

Acta Cytologica

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“…Adenosine deaminase (ADA) ↓ 1 0.00 --0.00 2.89E-03 serum, acite [44] O08557 N(G), N(G)-dimethylarginine dimethylamino hydrolase 1 [50] P26772 10 kDa heat shock protein (CH10) [51] Q00657 Chondroitin sulfate proteoglycan 4 (CSPG4)…”

Section: Urine Proteome Changes In Nutu-19 Cell Intraperitoneal-injecmentioning

confidence: 99%

Dynamic changes in the urine proteome in two ovarian cancer rat models

Zhang

Meng

et al. 2019

Preprint

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Ovarian cancer is the most lethal gynecological malignancy in women, and it is likely to metastasize and has a poor prognosis. The early and reliable diagnosis and monitoring of ovarian cancer is very important. Without a homeostasis mechanism, urine can reflect early systemic changes in the body and has a great potential to be used for the early detection of cancer. This study tested whether early changes could be detected in two ovarian cancer rat models. Two rat models were established by either intraperitoneal (i.p.) or orthotopic (o.t.) injection of NuTu-19 ovarian cancer cells in female Fischer344 rats. Urine samples from ovarian cancer rats were collected at five time points during cancer development, and urinary proteins from the rats were profiled by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Compared with pre-injection samples, 49 differential proteins that have human orthologues were significantly changed in the orthotopically injected model. Among them, 24 of the differential proteins have previously been reported to be associated with ovarian cancer, six of which were reported to be biomarkers of ovarian cancer. On the 7th day after orthotopic injection, four differential proteins (APOA1, OX2G, CHMP5, HEXB) were identified before obvious metastases appeared. In the intraperitoneal injection model, 76 differential proteins were changed during the course of ovarian cancer development. The results show that urine proteins could enable the early detection and monitoring of ovarian cancer progression and could lay a foundation for further exploration of the biomarkers of ovarian cancer. IntroductionOvarian cancer (OC) is the most lethal gynecological malignancy and it is the fifth leading cause of cancer death in women [1] , mainly because OC can spread to intraperitoneal tissues, such as the omentum in the peritoneal cavity, by the time of diagnosis [2] . The strongest risk factors for this disease are an advanced age and a family history of ovarian cancer. Epithelial ovarian cancer (EOC) is the most common ovarian malignancy and comprises 90% of all ovarian cancers [3] . More than 75% of affected women ovarian carcinomas are not diagnosed until a late stage (stage III or IV) because early-stage disease is not obvious and early symptoms, as well as symptoms of late-stage disease, are nonspecific.Pelvic or abdominal pain, a feeling of pelvic mass and abdominal swelling are the main clinical symptoms, but these are not specific to OC [4] . Currently, women who have symptoms consistent with ovarian cancer usually undergo a physical examination, transvaginal ultrasonography, and measurement of biomarkers such as CA125, but imaging and serum biomarkers tests are of limited 2 value in the early diagnosis of the ovarian carcinomas [5] . The treatment of ovarian cancer usually involves surgery and intraperitoneal and intravenous chemotherapy [6] . At present, patients are typically diagnosed at the advanced stage when the cancer has disseminated within the peritoneal cavity, and comp...

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Pathology of Ovary: Sex Cord Tumours

Dey

2018

Color Atlas of Female Genital Tract Pathology

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Ovarian steroid cell tumor, not otherwise specified: A clinicopathological and immunohistochemical experience of 12 cases

Abstract: Steroid cell tumors are very rare ovarian tumors in the Pakistani population, mostly presenting in adulthood. Diverse histological differentials exist so special stains and immunohistochemical stains are needed to distinguish these from other tumors.

Cited by 18 publications

References 30 publications

Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Dynamic changes in the urine proteome in two ovarian cancer rat models

Pathology of Ovary: Sex Cord Tumours

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