“…A thorough search of literature revealed that there are only 11 manuscripts and 1 published abstract addressing the safety and efficacy of TOS. There are 8 observational studies (7 manuscripts and 1 published abstract) [Abuzeid M et al, 2002; Quahba et al, 2004; Carbonnel et al 2011; Poncelet et al, 2012; Pellicano et al, 2014; Trehan A and Trehan AK 2014; Abuzeid O et al, 2018, Mitwally et al, 2009], 2 systematic reviews (Pergialiotis et al, 2016; Giampaolino et al, 2018), and 2 prospective randomized control trials (Seracchioli et al, 2014; Hoo et al, 2014).…”