Ovarian tissue health after laparoscopic unilateral oophorectomy: A porcine model for establishing optimized fertility preservation techniques in children

Rowell, Erin E.; Corkum, Kristine S.; Even, Kelly A.; Laronda, Monica M.

doi:10.1016/j.jpedsurg.2019.12.014

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…Erin Rowell, MD, discussed the development of a new porcine model of pediatric laparoscopic oophorectomy that is being used to test an ultrasound-based tissue removal technique. Using this model, researchers found that when the ultrasound device is placed far from the cortical capsule compared to close to the capsule, various markers of ovarian tissue cortex health were improved (ovarian tissue consumed glucose and produced less lactate and also produced more estradiol) [ 43 ]. Dr. Rowell also described their program’s surgical technique for pediatric laparoscopic oophorectomy, including optimal port placement at different pediatric developmental stages and technical principles such as scope placement, confirmation of ovary symmetry, and a “no touch technique” in which the mesovarium is grasped directly adjacent to the cortical tissue, stretched, and incised with an ultrasound energy device using a medial to lateral approach > 1 cm distant from the cortex [ 44 ].…”

Section: Conference Session Synopsismentioning

confidence: 99%

A synopsis of global frontiers in fertility preservation

Ataman

Laronda

Gowett

et al. 2022

J Assist Reprod Genet

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Since 2007, the Oncofertility Consortium Annual Conference has brought together a diverse network of individuals from a wide range of backgrounds and professional levels to disseminate emerging basic and clinical research findings in fertility preservation. This network also developed enduring educational materials to accelerate the pace and quality of field-wide scientific communication. Between 2007 and 2019, the Oncofertility Consortium Annual Conference was held as an in-person event in Chicago, IL. The conference attracted approximately 250 attendees each year representing 20 countries around the world. In 2020, however, the COVID-19 pandemic disrupted this paradigm and precluded an in-person meeting. Nevertheless, there remained an undeniable demand for the oncofertility community to convene. To maintain the momentum of the field, the Oncofertility Consortium hosted a day-long virtual meeting on March 5, 2021, with the theme of “Oncofertility Around the Globe” to highlight the diversity of clinical care and translational research that is ongoing around the world in this discipline. This virtual meeting was hosted using the vFairs ® conference platform and allowed over 700 people to participate, many of whom were first-time conference attendees. The agenda featured concurrent sessions from presenters in six continents which provided attendees a complete overview of the field and furthered our mission to create a global community of oncofertility practice. This paper provides a synopsis of talks delivered at this event and highlights the new advances and frontiers in the fields of oncofertility and fertility preservation around the globe from clinical practice and patient-centered efforts to translational research. Supplementary Information The online version contains supplementary material available at 10.1007/s10815-022-02570-5.

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Section: Conference Session Synopsismentioning

confidence: 99%

A synopsis of global frontiers in fertility preservation

Ataman

Laronda

Gowett

et al. 2022

J Assist Reprod Genet

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“…Many pediatric surgeons and gynecologists perform unilateral laparoscopic oophorectomy, using an ultrasonic advanced energy device to segment the ovarian artery and mesovarium. No major surgical complications have been observed with this technique ( 44 ).…”

Section: Discussionmentioning

confidence: 91%

Ovarian tissue cryopreservation in the pediatric with rare diseases- experience from China’s first and the largest ovarian tissue cryobank

Ruan

Cheng

et al. 2023

Front. Endocrinol.

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BackgroundThere is limited information about the efficacy of ovarian tissue cryopreservation (OTC) in children. In the present study, we report eight patients with rare diseases who underwent OTC in China’s first and largest ovarian tissue cryobank.ProcedureData from girls with rare diseases who underwent OTC between September 2020 and November 2022 were retrospectively analyzed. We also compared the number of cryopreserved cortex pieces, follicle number, and AMH in those with rare diseases and age-matched children with non-rare diseases who also underwent OTC in our cryobank.ResultsThe median age of the children was 5.88 ± 3.52 (range 2-13) years old. Unilateral oophorectomy was undertaken via laparoscopy in all of the children. The diseases in the 8 patients were: 4 mucopolysaccharidoses (MPS I two cases, IVA two cases), 1 Diamond-Blackfan anemia (DBA), 1 Fanconi anemia (FA), 1 hyperimmunoglobulin E syndrome (HIES), 1 Niemann-Pick disease. The number of cryopreserved cortex pieces was 17.13 ± 6.36, and the follicle count per 2 mm biopsy was 447.38 ± 524.35. No significant difference in age, the count of cryopreserved cortex pieces, follicle number per 2 mm biopsy, and AMH level was seen between the 20 children with non-rare diseases and those with rare diseases.ConclusionsThe reports help practitioners counsel girls with rare diseases about fertility preservation. The demand for OTC in pediatrics will likely grow as a standard of care.

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“…Air transportation of tissue to a cryopreservation facility is a possibility for patients unable to seek treatment at a larger center [39]. Surgical technique should be continued to be optimized as ultrasonic surgical devices may cause less estradiol production and higher rates of folliculogenesis compared with sharp cold dissection of the ovary [40].…”

Section: Surgical/techniquesmentioning

confidence: 99%

Fertility preservation in children and young adults with cancer

Brungardt

Burns²,

Dasgupta

2021

Current Opinion in Pediatrics

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Purpose of reviewThe issue of fertility preservation has become increasingly relevant as survival rates of children with cancer exceeds 80% at 5 years. Fertility preservation options are being utilized alongside less gonadotoxic therapeutic regimens in the treatment of these patients. The purpose of this review is to summarize the recent advances in fertility preservation in the pediatric, adolescent, and young adult population. Recent findingsEducation research involves both patient and provider; to increase understanding on both sides for improved adoption of techniques and higher rates of posttreatment fertility. Basic science research, specific to the pediatric population, has worked to further understanding of protective techniques and cryopreserved tissue transfer. Research on the techniques of preservation confirms the safety of surgical gonadal (ovarian and testicular) tissue retrieval for cryopreservation but a viable pathway for testicular tissue utilization, as it has for ovarian, has yet to be realized. Outcomes may be improving but it is apparent that robust registries are necessary to track patients long-term. Possibly the largest advancement in the recent past are group efforts, such as by PanCareLIFE, to create guidelines for these issues using larger cohorts and registries than were available.

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Ovarian tissue health after laparoscopic unilateral oophorectomy: A porcine model for establishing optimized fertility preservation techniques in children

Cited by 11 publications

References 14 publications

A synopsis of global frontiers in fertility preservation

A synopsis of global frontiers in fertility preservation

Ovarian tissue cryopreservation in the pediatric with rare diseases- experience from China’s first and the largest ovarian tissue cryobank

Fertility preservation in children and young adults with cancer

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