Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites

Jiang, Haojie; Du, Yaoyao; Li, Yufeng

doi:10.1007/s11596-021-2342-1

Cited by 10 publications

(4 citation statements)

References 114 publications

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“…Exposure to widely used endocrine disrupting chemicals, including phthalates released into the environment during extreme weather events can alter the physiologic function of the female reproductive system through endocrine blocking chemical effects on the endocrine system. These chemical exposures have been linked to infertility, complications of or pregnancy loss, and increased risk for the development of female reproductive cancers during menopause (Jiang et al, 2021). Exposure to phthalates, parabens, and phenols in utero is also influential in pubertal timing in females (Harley et al, 2019).…”

Section: Direct and Indirect Mechanisms Affecting Maternal Child Healthmentioning

confidence: 99%

Climate and Environmental Change

Chalupka

Latter

Trombley

2023

McN: The American Journal of Maternal/Child Nursing

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Climate and environmental changes have been described as the biggest global health threat of the 21st century, with the potential to cause immediate harm in early life with important lifelong effects, and important consequences for future generations. Pregnant women and children are increasingly being recognized as vulnerable populations in the context of climate change. The effects can be direct or indirect through heat stress, extreme weather events, and air pollution, potentially affecting both the immediate and long-term health of pregnant women and newborns through a broad range of mechanisms. Climate and environmental changes have wide-ranging effects on a woman's reproductive life including sexual maturation and fertility, pregnancy outcomes, lactation, breastfeeding, and menopause. A comprehensive overview of these impacts is presented as well as opportunities for interventions for nurses practicing in perinatal, neonatal, midwifery, and pediatric specialties.

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Section: Direct and Indirect Mechanisms Affecting Maternal Child Healthmentioning

confidence: 99%

Climate and Environmental Change

Chalupka

Latter

Trombley

2023

McN: The American Journal of Maternal/Child Nursing

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“…Their primary route of entry into the human body is either by oral ingestion, inhalation, or dermal contact, after which they are metabolised and accumulate to measurable levels in blood, urine, breast milk and follicular fluids (Hannon and Flaws, 2015). Phthalates disrupt reproductive health by targeting the processes of folliculogenesis and steroidogenesis, and by inducing epigenetic changes in the ovary (Jiang et al, 2021). Their exposure is linked to infertility, premature puberty, asthma, and neurodevelopmental diseases (Singh and Li, 2011).…”

Section: Chemical-induced Reproductive Dysfunctionmentioning

confidence: 99%

C. elegans as a model organism to study female reproductive health

Athar

Templeman

2022

Comparative Biochemistry and Physiology Part A: Molecular &

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“…Some environmental pollutants mentioned above have a significant impact on the reproductive health of offspring. Prenatal exposure to some toxic substances, especially a class of endocrine disruptors, such as phthalates [ 152 ], metoclopramide [ 121 ], etc., may directly target the ovary and affect follicular development, alter the epigenetic information in oocytes, and lay out epigenetic effects across generations [ 153 ]. Long-term exposure to environmental diuron in F0 marine medaka inhibits F1 ovary development [ 141 ].…”

Section: Multisystem Diseasesmentioning

confidence: 99%

Developmental origins of adult diseases

Liu

Huang

et al. 2022

Medical Review

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The occurrence and mechanisms of developmental adult diseases have gradually attracted attention in recent years. Exposure of gametes and embryos to adverse environments, especially during plastic development, can alter the expression of certain tissue-specific genes, leading to increased susceptibility to certain diseases in adulthood, such as diabetes, cardiovascular disease, neuropsychiatric, and reproductive system diseases, etc. The occurrence of chronic disease in adulthood is partly due to genetic factors, and the remaining risk is partly due to environmental-dependent epigenetic information alteration, including DNA methylation, histone modifications, and noncoding RNAs. Changes in this epigenetic information potentially damage our health, which has also been supported by numerous epidemiological and animal studies in recent years. Environmental factors functionally affect embryo development through epimutation, transmitting diseases to offspring and even later generations. This review mainly elaborated on the concept of developmental origins of adult diseases, and revealed the epigenetic mechanisms underlying these events, discussed the theoretical basis for the prevention and treatment of related diseases.

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Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites

Cited by 10 publications

References 114 publications

Climate and Environmental Change

Climate and Environmental Change

C. elegans as a model organism to study female reproductive health

Developmental origins of adult diseases

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