Ovarian toxicity of nanoparticles

Santacruz-Márquez, Ramsés; Santos, Marijose González-De los; Hernández‐Ochoa, Isabel

doi:10.1016/j.reprotox.2021.06.002

Cited by 17 publications

(4 citation statements)

References 142 publications

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“…The rise of oxidative stress level and of Cyp17a1 gene expression, together with altered regulation of many (about 288) ovarian genes, account for the decline of fertility and pregnancy rate. In vivo, increased estrogen release and decreased testosterone/progesterone levels have been detected in rodents of various strains treated with increasing concentrations of TiO 2 NPs [ 70 ]. Contrasting effects on steroid hormone release have been obtained by Hong and Wang [ 71 ] and Zhao et al [ 72 ] following mice exposure to similar concentrations of anatase-nTiO 2 (2.5–5–10 mg/kg for 30 days), but differences can be ascribed to different treatment times and different mouse strains used in the experiments.…”

Section: Np-induced Toxicity In Ovary and Oocytesmentioning

confidence: 99%

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Aloisi

Rossi

Colafarina

et al. 2022

IJERPH

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Humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and our bodily systems are well adapted to protect us from these potentially harmful external agents. However, technological advancement has dramatically increased the production of nanometer-sized particles or nanoparticles (NPs), and many epidemiological studies have confirmed a correlation between NP exposure and the onset of cardiovascular diseases and various cancers. Among the adverse effects on human health, in recent years, potential hazards of nanomaterials on female reproductive organs have received increasing concern. Several animal and human studies have shown that NPs can translocate to the ovary, uterus, and placenta, thus negatively impacting female reproductive potential and fetal health. However, NPs are increasingly being used for therapeutic purposes as tools capable of modifying the natural history of degenerative diseases. Here we briefly summarize the toxic effects of few but widely diffused NPs on female fertility and also the use of nanotechnologies as a new molecular approach for either specific pathological conditions, such as ovarian cancer and infertility, or the cryopreservation of gametes and embryos.

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Section: Np-induced Toxicity In Ovary and Oocytesmentioning

confidence: 99%

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Aloisi

Rossi

Colafarina

et al. 2022

IJERPH

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“…Nanoparticle accumulation and toxicity in the ovary has been documented to occur in recent studies [ 16 ]. Interestingly, one study found that NPs can reach specific localizations within the ovary.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Zinc Oxide Nanoparticles Increases Estradiol Levels and Induces an Antioxidant Response in Antral Ovarian Follicles In Vitro

Santacruz-Márquez

Flaws

Sánchez-Peña

et al. 2023

Toxics

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The use of zinc oxide nanoparticles (ZnO NP) in consumer products is increasing, raising concern about their potential toxicity to human health. Nanoparticles have endocrine disrupting effects and can induce oxidative stress, leading to biomolecule oxidation and cell dysfunction. The ovary is one of the most important endocrine organs in female reproduction. Nanoparticles accumulate in the ovary, but it is unknown whether and how exposure to these materials disrupts antral follicle functions. Thus, this study tested the hypothesis that the in vitro exposure to ZnO NPs affects the steroidogenic pathway and induces oxidative stress in ovarian antral follicles. Antral follicles from CD-1 mice were cultured with ZnO NPs (5, 10, and 15 µg/mL) for 96 h. ZnO NP exposure did not affect apoptosis and cell cycle regulators at any of the tested concentrations. ZnO NP exposure at low levels (5 µg/mL) increased aromatase levels, leading to increased estradiol levels and decreased estrogen receptor alpha (Esr1) expression. ZnO NP exposure at 15 µg/mL induced an antioxidant response in the antral follicles as evidenced by changes in expression of antioxidant molecules (Nrf2, Cat, Sod1, Gsr, Gpx) and decreased levels of reactive oxygen species. Interestingly, ZnO NPs dissolve up to 50% in media and are internalized in cells as soon as 1 h after culture. In conclusion, ZnO NPs are internalized in antral follicles, leading to increased estrogen production and an antioxidant response.

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“… 12 Ovarian health is easily affected by environmental factors such as air pollution, heavy metals, toxic chemicals, or nanoparticles. 13 Nanoparticles enter the body via inhalation or ingestion and are then absorbed into the bloodstream, where they are finally deposited in secondary organs, including the ovaries, where they can cause varying types of damage. 14 In vivo, the sonic hedgehog signaling pathway is activated and causes the apoptosis of ovarian cells after exposure to ZnO NPs.…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide Particles Can Cause Ovarian Toxicity by Oxidative Stress in Female Mice Model

Xu¹,

Zhao²,

Liu³

et al. 2022

IJN

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Introduction Zinc oxide nanoparticles (ZnO NPs) participate in all aspects of our lives, but with their wide application, more and more disadvantages are exposed. The goal of this study was to investigate the toxicity of ZnO NPs in female mice ovaries and explore its potential mechanism. Methods In this study, adult female mice were orally exposed to 0, 100, 200, and 400 mg/kg ZnO NPs for 7 days. We explored the underlying mechanisms via the intraperitoneal injection of N-acetyl-cysteine (NAC), an inhibitor of oxidative stress, and salubrinal (Sal), an inhibitor of endoplasmic reticulum (ER) stress. Results The results indicated that serum estradiol and progesterone levels declined greatly with increasing ZnO NPs dosage. Hematoxylin and eosin (HE) staining revealed increased atretic follicles and exfoliated follicular granulosa cells. Moreover, at the transcriptional level, antioxidant-related genes such as Keap1 and Nrf2 , and ER stress-related genes PERK, eIF2α , and ATF4 were markedly upregulated. In addition, the expression of Caspase12, Caspase9 , and Caspase3 , which are genes related to apoptosis, was also upregulated in all ZnO NPs treatment groups. Serum malondialdehyde (MDA) content was remarkably up-regulated, whereas superoxide dismutase (SOD) activity was down-regulated. The 400 mg/kg ZnO NPs treatment group suffered the most substantial harm. However, ovarian damage was repaired when NAC and Sal were added to this group. Conclusion ZnO NPs had toxic effects on the ovary of female mice, which were due to oxidative stress, ER stress, and the eventual activation of apoptosis.

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Ovarian toxicity of nanoparticles

Cited by 17 publications

References 142 publications

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Exposure to Zinc Oxide Nanoparticles Increases Estradiol Levels and Induces an Antioxidant Response in Antral Ovarian Follicles In Vitro

Zinc Oxide Particles Can Cause Ovarian Toxicity by Oxidative Stress in Female Mice Model

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