Ovarian tumors in pediatric age group - A clinicopathologic study of 10 years′ cases in West Bengal, India

Bhattacharyya, Nirmal Kumar; De, Anuradha; Bera, Pranati; Sristidhar, Mongal; Chakraborty, Subrata; Bandopadhyay, Rajat

doi:10.4103/0971-5851.71656

Cited by 23 publications

(27 citation statements)

References 6 publications

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“…No documented emergent acute abdomen unlike some reports [10,11]. None of our 2 JSCT cases has precocious puberty, however Bhattacharyya et al [2] in India found 2 cases with precocious puberty out of 3 in his series of 151 malignant pediatric ovarian tumor patients.…”

Section: Discussioncontrasting

confidence: 47%

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Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Sarhan¹,

Halim²,

Elzayat³

et al. 2017

JCTI

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Background: Pediatric ovarian tumors are rare. The aim of this work is to study the epidemiological characteristics and treatment outcome of these tumors in our locality. Methods: This retrospective study was performed in accordance with the ethical policies. Between January 2011 to December 2015, Thirteen cases of pediatric ovarian cancers were recorded in the Pediatric Oncology Unit of Oncology Center of Mansoura University and the Clinical Oncology & Nuclear Medicine Department of Mansoura University Hospital. The clinico-epidemiologic data and the treatment protocols were analyzed. Results: The median age was 10 years (range: 2-17). Presenting symptoms were mainly lower abdominal pain (6; 46.2%) and palpable abdominal mass (4; 30.7). Through laparotomy all patients underwent unilateral salpingo-oophorectomy except one case for whom bilateral salpingiooophorectomy was done. Six patients were stage I (46.2%), 2 patients were stage II (15.4%) and 5 patients were stage III tumors (38.4%). The majority had germ cell tumors (11; 85%). Adjuvant chemotherapy was given to all cases. Further chemotherapy was needed in 6 cases due to progression or recurrence. The median follow up was 35 months while the median overall survival was 40 months. Mortality rates were 90% in stages II and III together. The advanced stages and yolk sac pathology had the highest mortality. One of the survived cases got married and delivered a baby. Conclusion: Germ cell tumors are the commonest pediatric malignant ovarian tumors. Multimodality treatment is essential. Fertility preservation should be respected. Our mortality rates are relatively high.

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Section: Discussioncontrasting

confidence: 47%

“…[1,2]. Tumors of the ovary may be benign like mature cystic teratomas or malignant like yolk sac tumors.…”

Section: Introductionmentioning

confidence: 99%

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Sarhan¹,

Halim²,

Elzayat³

et al. 2017

JCTI

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“…Ovarian malignancy accounts for 1% of all the childhood tumours in the previous studies but some studies like Oumachigui et al, 1991 and Sawai MM et al, 1973 found the incidence to be as high as six per cent and 11.2% respectively [2, 11, 12]. In the study conducted by Bren JL et al it was reported that 35% of all ovarian neoplasms in childhood and adolescent were malignant (Bren JL et al, 1977) [13].…”

Section: Discussionmentioning

confidence: 99%

“…They account for 1% of all the childhood malignancies and 8% of all abdominal tumours in children. It is estimated that almost 10-30% of all the ovarian neoplasms occurring in girls up to 17 years of age are malignant [1, 2]. Tumours of the Ovary are divided into neoplastic and non-neoplastic processes.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution

Rathore

Sharma

Arora

2016

Open Access Maced J Med Sci

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BACKGROUND:Ovarian tumour in children and adolescent girls form an uncommon but important part of gynaecological malignancies. They account for 1% of all the childhood malignancies and 8% of all abdominal tumours in children. Since the ovarian cysts are thought to arise from mature follicles, these tumours were considered to be infrequent in the paediatric population.AIM:The rarity of this condition prompted us to conduct this study and share our experience on the incidence and clinicopathological features of different ovarian tumours in girls up to 20 years of age observed in last 25 years at a single tertiary care hospital.MATERIAL AND METHODS:This was a retrospective study conducted in the Department of Pathology at a tertiary hospital, Delhi. All ovarian tumours up to the age of 20 years in the past 25 years (1990-2014) were included for the purpose of studying the clinicopathological aspects of ovarian tumours in this age group. Descriptive statistics for prevalence and age-wise prevalence was done. Chi-square test, to find an association between the age, laterality and size with malignancy was performed.RESULTS:We received a total of 1102 cases of ovarian tumours over the period of 25 years (1990 to 2014), of which 112 (10%) cases were seen in girls up to 20 years of age. The mean age of the patients was 15.3 ± 4 years. The most common presenting complaint was pain abdomen (46.4 %) There was a statistically significant correlation found between size and malignancy status of tumours in our study (p = 0.00). Of 112 cases of ovarian tumours, 39/112 (34.8%) were malignant and 73/112 (65.2%) were benign. Mature cystic teratoma (27.6%) was the most common type of benign tumour in this age group and immature teratomas were the most common type of malignant ovarian neoplasms.CONCLUSION:Premenarchal girls with ovarian masses may have varied presentations. Abdominal pain is the most common presenting complaint of young adolescent girls with adnexal masses. So the index of suspicion should be kept high and prompt investigations like ultrasound must be performed early to rule out such adnexal masses. Immature Teratoma was the most common malignant and mature cystic teratoma was the most common benign tumour in our study.

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“…There were 9 cases of malignant surface epithelial tumour. 7 In the prospective study conducted at the Department of Obstetrics and Gynaecology, Tribhuvan University, 80 cases in childhood and adolescent were studied, majority belonged to 15-19 years. Germ cell tumours account for 73.7%.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological profile of ovarian tumors in the age group 10-20 years

Priya

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Adolescence is the period of transition from childhood to adulthood. 1% neoplasm occurs in this age group below 17 years, of this, 3% are ovarian neoplasms. Aim was to study retrospectively the clinicopathological profile and outcome of ovarian tumors in the age group 10-20 years in Government Medical College, Kottayam, Kerala, India from January 2008 for six years. Methods: Fifty Patients who have undergone laparotomy in this institution during the period were taken for study. Data regarding age, mode of presentation, diagnostic methods, treatment and histopathology were recorded. Followup was also taken into consideration. Patients with polycystic ovary, corpus luteal cyst, follicular cyst and endometriotic cyst are excluded. Results: Majority of the patients fall between the age group 15-20 years. Major clinical presentation was pain (40%), followed by abdominal mass. Laparotomy was done for all cases except three where laparoscopy was done. Imprint cytology taken for 3 cases. Histopathology showed malignant tumors in 6 cases and benign tumors in 44 cases. Epithelial tumors outnumbered germ cell tumors. Conclusions: This study shows the predominance of epithelial neoplasms in the age group 10-20 years. Proportion of malignancy is 12%.

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Ovarian tumors in pediatric age group - A clinicopathologic study of 10 years′ cases in West Bengal, India

Cited by 23 publications

References 6 publications

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution

Clinicopathological profile of ovarian tumors in the age group 10-20 years

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