Ovarian tumors in relapsing acute lymphoblastic leukemia: A review of 23 cases

Pais, Ray; Kim, Tae Hyong; Zwiren, Gerald T.; Ragab, Abdelsalem H.

doi:10.1016/0022-3468(91)90430-2

Cited by 26 publications

(16 citation statements)

References 17 publications

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“…By that time, this patient also showed evidence of disease recurrence in the bone marrow. This case and significantly large series of similar cases published by Pars and Kim et al suggest that at least biannual gynaecological pelvic examination should be included in regular follow-up of adult females after completion of their therapy to detect EMR in limited stage [9,23].…”

Section: Discussionmentioning

confidence: 93%

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An Unusual Site of Acute Lymphoblastic Leukaemia Relapse: Challenge for Gynaecologists

Sahu

Prakash

Sanamandra

et al. 2015

J Obstet Gynecol India

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Section: Discussionmentioning

confidence: 93%

“…Many a time diagnosis is made after receiving the final report of biopsied/resected specimens [21,22]. [9,23]. In the review study by Kim et al, the average duration of ovarian relapse from initial diagnosis of ALL was 53.7 months.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Site of Acute Lymphoblastic Leukaemia Relapse: Challenge for Gynaecologists

Sahu

Prakash

Sanamandra

et al. 2015

J Obstet Gynecol India

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“…The largest series of ALL-associated ovarian tumors was published by Pais et al [2]. In their study of five cases, and a review of an additional 18 from the medical literature, the incidence appeared to be decreasing over the last decades, possibly due to improved chemotherapeutic regimens.…”

Section: Discussionmentioning

confidence: 97%

“…However, the ovaries are infrequently identified as the primary site of leukemic relapse [3][4][5]. Twenty-three reports have been published in the English literature [1,2,; since the early 2000s, only one case (this case) has been diagnosed with this finding.…”

Section: Discussionmentioning

confidence: 97%

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Ovarian and multiple lymph nodes recurrence of acute lymphoblastic leukemia: a case report and review of literature

et al. 2008

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Ovarian involvement of acute lymphoblastic leukemia (ALL) without relapse in the bone marrow or other extramedullary site is rare. We report a case of ovarian relapse in a 13-year-old girl who was diagnosed with ALL at the age of 11. A complete remission was induced with the Children Cancer Group 1882 protocol for high-risk-groups. After maintenance chemotherapy, the patient remained in relatively good health for the next 4 months. The patient presented with intermittent colicky right lower quadrant pain of 1-day duration. The pelvic ultrasound (US) showed a lobulated mixed echogenic mass in the right ovary, and an exploratory laparotomy was performed. Although uncommon, ovarian recurrence after treatment for ALL should be considered in patients with suggestive symptoms. Regular pelvic US is easy to perform and has no side effects and can help detect ovarian tumors early in ALL survivors.

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Relapse of acute lymphoblastic leukemia in the inferior rectus muscle of the eye

Hinkle¹,

Dinndorf²,

Bulas³

et al. 1994

Cancer

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Background. Extramedullary involvement of acute lymphoblastic leukemia (ALL) in sites outside the central nervous system (CNS) or testes is rare and may signal a refractory form of leukemia. Methods. The authors describe a child with ALL who experienced a relapse involving the inferior rectus muscle of the eye. This patient had been treated with a bone marrow transplant for previous bone marrow and ovarian relapse. Results. The patient had a pre‐B ALL with a t(1;19) chromosomal translocation and previously had experienced relapse during therapy. At the time of the muscle relapse, she had pancreatomegaly consistent with leukemic infiltration but no CNS or bone marrow disease. Conclusions. Relapse of ALL in unusual sites may indicate disease that is particularly difficult to eradicate. Factors in addition to age and leukocyte count at diagnosis determine risk. Additional research is needed to define these factors and develop more effective therapy.

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Ovarian tumors in relapsing acute lymphoblastic leukemia: A review of 23 cases

Cited by 26 publications

References 17 publications

An Unusual Site of Acute Lymphoblastic Leukaemia Relapse: Challenge for Gynaecologists

An Unusual Site of Acute Lymphoblastic Leukaemia Relapse: Challenge for Gynaecologists

Ovarian and multiple lymph nodes recurrence of acute lymphoblastic leukemia: a case report and review of literature

Relapse of acute lymphoblastic leukemia in the inferior rectus muscle of the eye

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