Ovarian volume: a novel outcome predictor for assisted reproduction

Syrop, Craig H.; Willhoite, Ann; Voorhis, Bradley J. Van

doi:10.1016/s0015-0282(16)57979-5

Cited by 128 publications

(57 citation statements)

References 11 publications

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“…Our cut-off point for ovarian volume that discriminated the poor and normal responder was 2.98 cm 3 with a sensitivity of 75% and specificity of 81.2%. The results of the current study, as well as those reported by others, do support that ovarian volume, measured by transvaginal ultrasound, has been correlated well with response to ovulation induction in ART cycles (18)(19)(20)32). Small ovaries (<3 cm 3 ) were found to predict poor response to ovarian stimulation and high cancellation rates but not pregnancy achievement (19).…”

Section: Discussionsupporting

confidence: 89%

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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Purpose : To compare basal and clomiphene citrate (CC) induced follicle-stimulating hormone (FSH), estradiol (E 2 ), and inhibin B levels with ultrasound indices of ovarian reserve in infertile women and to test the prognostic value of these tests on response to ovarian stimulation in in vitro fertilization (IVF). Methods : Fifty-six patients had basal and CC induced serum hormone levels and ultrasound measured mean ovarian volume (MOV) and mean antral follicle counts (MFC). Thirty-two patients were then appropriately selected to have a total of 41 cycles of IVF/ICSI treatment. Results : Women with diminished ovarian reserve had lower MOV, MFC, day 3 and day 10 inhibin B levels ( p < 0.001). Only basal and CC induced FSH and inhibin B correlated with MOV and MFC. Poor responders in IVF/ICSI had higher basal FSH ( p < 0.05), lower basal and induced inhibin B levels ( p < 0.05), and lower MOV and MFC ( p < 0.01) than normal responders. Ovarian volume alone was better than age and basal hormones in predicting poor ovarian response, while abnormal CC test was the only independent significant factor in predicting ovarian response. However, age was the only independent predictor of pregnancy in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion : CC test and ovarian volume are better than other hormonal and sonographic tests in predicting the response to ovarian stimulation in IVF cycles.

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Section: Discussionsupporting

confidence: 89%

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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“…The basal antral follicular count and ovarian volume measured during vaginal ultrasonography can offer accurate predictions of ovarian response. 91,92 Some dynamic tests have been designed to further test the ability of the ovaries to respond to medication. These tests, such as the clomiphene citrate challenge test, 93 the gonadotropin-releasing hormone (GnRH) agonist stimulation test, 94 and the exogenous FSH ovarian reserve test, 95 are usually reserved for situations in which the previous medical history, physical examination, and other less time-consuming tests cannot determine the prognosis and the most adequate way to stimulate the patient's ovaries.…”

Section: It Is Imperative For the Physician To Appropriately Counsel mentioning

confidence: 99%

Advances and Controversies in Assisted Reproductive Technology

Vela

Luna

Sandler

et al. 2009

Mount Sinai J Medicine

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As the incidence and awareness of infertility have increased in the last decades, reproductive endocrinologists and scientists have striven to improve the therapeutic options being offered to patients. One of the most advanced and efficient technologies currently being offered is assisted reproductive technology. Among the various techniques that are comprised by assisted reproductive technology, in vitro fertilization is the most widely studied and used, being responsible for approximately 1% of all live births in the United States. As this technology has evolved, many controversies have arisen, and it is the purpose of this article to review what in the authors' opinion are the most current and controversial aspects of the whole process of in vitro fertilization and its related techniques. Mt Sinai J Med 76:506‐520, 2009. © 2009 Mount Sinai School of Medicine

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“…Consistent with the findings from the present study, both Flaws et al 16 and Bastos et al 9 showed no statistically significant association between cigarette smoking and ovarian volume in cross-sectional studies of 527 pre-and postmenopausal women participating in a uterine fibroid study and 273 women aged 36-62 years living in Southern Brazil, respectively. In contrast, two studies conducted among women undergoing assisted reproductive care showed that smoking was associated with a reduction in ovarian volume 22 and a lower mean number of retrieved oocytes. 15 As suggested by Flaws et al, 16 it is possible that the associations between smoking and ovarian volume differ among healthy women compared to infertile women and that the ovaries from infertile women may be more susceptible to the toxic effects of cigarette smoke than ovaries from healthy women.…”

Section: Discussionmentioning

confidence: 85%

The Associations Between Body Mass Index, Smoking, and Alcohol Intake with Ovarian Volume in Midlife Women

Gallicchio

Miller

Kiefer

et al. 2016

Journal of Women's Health

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Background: Despite the fact that ovarian volume is a marker of reproductive aging, there is little understanding of factors related to ovarian volume among aging women. The objective of this analysis was to examine the associations between body mass index (BMI), cigarette smoking, and alcohol intake with ovarian volume among midlife women. Materials and Methods: Data were analyzed from 771 women (45-54 years of age at baseline) enrolled in the Midlife Women's Health Study, a cohort study that was initiated in 2006. At annual clinic visits, height and weight were measured, a transvaginal ultrasound was performed to measure ovarian volume, blood was drawn to measure hormone concentrations, and a comprehensive questionnaire was administered. Generalized linear models and repeated measures mixed models were conducted to examine the associations between BMI, cigarette smoking, and alcohol intake with ovarian volume, adjusting for age and race. Results: Age was significantly and negatively associated with ovarian volume. However, BMI, smoking, and alcohol use were not associated with ovarian volume either when stratified by menopausal status or when adjusting for age and race. Estradiol, but not progesterone or testosterone, was significantly and positively associated with ovarian volume overall and among both white and black participants ( p < 0.05). Conclusions: This study provides insight into the associations between BMI, smoking, and alcohol use with ovarian volume among midlife women. The findings are somewhat consistent with the published literature and, thus, indicate that these factors may not be clinically important in terms of ovarian volume during the menopausal transition.

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Ovarian volume: a novel outcome predictor for assisted reproduction

Cited by 128 publications

References 11 publications

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Advances and Controversies in Assisted Reproductive Technology

The Associations Between Body Mass Index, Smoking, and Alcohol Intake with Ovarian Volume in Midlife Women

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