2007
DOI: 10.1152/ajpendo.00246.2007
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Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats

Abstract: Bhuiyan MS, Shioda N, Fukunaga K. Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats. Am J Physiol Endocrinol Metab 293: E1606-E1614, 2007. First published September 18, 2007; doi:10.1152/ajpendo.00246.2007.-To elucidate the molecular mechanism underlying estrogen-mediated cardioprotection in left ventricular (LV) hypertrophy and remodeling, we analyzed myocardial hypertrophy as well as cardiac function and hyper… Show more

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Cited by 62 publications
(87 citation statements)
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“…Consistent with our previous observation, 7 LV end-diastolic pressure was significantly increased in the OVX-PO group (PϽ0.001 versus OVX) compared with the OVX group. VO(OPT) treatment dose-dependently restored elevated LV end-diastolic pressure (PϽ0.001 versus OVX-PO for 1.25 mg and PϽ0.001 versus OVX-PO for 2.50 mg of vanadium; Figure 2C).…”
Section: Effect Of Vo(opt) Treatment On Hemodynamic Parameterssupporting
confidence: 92%
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“…Consistent with our previous observation, 7 LV end-diastolic pressure was significantly increased in the OVX-PO group (PϽ0.001 versus OVX) compared with the OVX group. VO(OPT) treatment dose-dependently restored elevated LV end-diastolic pressure (PϽ0.001 versus OVX-PO for 1.25 mg and PϽ0.001 versus OVX-PO for 2.50 mg of vanadium; Figure 2C).…”
Section: Effect Of Vo(opt) Treatment On Hemodynamic Parameterssupporting
confidence: 92%
“…VO(OPT) treatment (2.50 mg of vanadium per kg) slightly decreased MABP in sham rats, but a significant decrease in MABP was observed in OVX rats ( Figure S2B). Consistent with a previous observation, 7 OVX-PO treatment significantly increases both in HR (PϽ0.01 versus OVX; Figure 2A) and in MABP (PϽ0.01 versus OVX; Figure 2B) compared with OVX rats. VO(OPT) treatment dose-dependently and significantly reduced HR (PϽ0.05 versus OVX-PO for 1.25 mg and PϽ0.05 versus OVX-PO for 2.50 mg of vanadium; Figure 2A) and MABP (PϽ0.05 versus OVX-PO for 1.25 mg and PϽ0.001 versus OVX-PO for 2.50 mg of vanadium; Figure 2B).…”
Section: Effect Of Vo(opt) Treatment On Hemodynamic Parameterssupporting
confidence: 92%
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