Ovariectomy Sensitizes Rat Cortical Bone to Whole-Body Vibration

Rubinacci, Alessandro; Marenzana, Massimo; Cavani, Francesco; Colasante, Federica; Villa, Isabella; Willnecker, J.; Moro, Giorgio; Spreafico, Luigi Paolo; Ferretti, Marzia; Guidobono, F.; Marotti, Gastone

doi:10.1007/s00223-008-9115-8

Cited by 61 publications

(52 citation statements)

References 42 publications

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“…The study of Rubinacci et al also suggested that the difference in response of the trabecular versus cortical bone compartments to loading may be sex hormone dependent and inhibited by estrogen in the cortical compartment. Such observations support the view that vibration loses its osteogenic potential when the estrogen axis is intact which is in agreement with the fact that estrogen acts as negative modulator of the mechanotransduction process [48].…”

Section: Discussionsupporting

confidence: 88%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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Section: Discussionsupporting

confidence: 88%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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“…For WBV, this conventional premise was challenged by the experimental animal models, which showed that exposures to low- Fig. 2 for further legends magnitude but high-frequency vibration can also enhance bone accrual [3][4][5][6][7][8][9][10][11]. These high-frequency, low-magnitude vibration signals are believed to piezoelectrically, or by stress-generated fluid flow, stimulate bone cells [2,17], with the bone anabolic effect increasing with increasing frequency [27,31].…”

Section: [ ]mentioning

confidence: 96%

“…Whether WBV can exert effects in addition to other simultaneous bone therapies such as calcium and vitamin D supplementation, exercise, and pharmacological interventions should also be further examined. 5.0.1 [19]. The correlation coefficient value (r) of 0.95 was used in all Follmann's calculations.…”

Section: [ ]mentioning

confidence: 99%

“…In experimental animal models, WBV was found to lead to anabolic bone changes [3][4][5][6][7][8][9][10][11]. Based on these data and the availability of many different WBV platforms in North America and Europe, optimistic claims that these benefits may translate to humans have been made within the scientific community [12] and in the media [13].…”

Section: Introductionmentioning

confidence: 99%

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Effect of whole-body vibration on BMD: a systematic review and meta-analysis

et al. 2010

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“…In recent years, more reports have provided evidences that estrogen action and mechanical loading on bone are independent [27] and additive in nature [3]. Some report that OVX sensitizes cortical bones to mechanical stimulation [37]; and interestingly, male adult rats with lower estrogen level demonstrate better mechanical response than females [21].…”

Section: Introductionmentioning

confidence: 98%