2013
DOI: 10.1186/1471-2415-13-6
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Over-expression of human cystatin C in pterygium versushealthy conjunctiva

Abstract: BackgroundA prospective, non-randomised, transversal and comparative study, carried out in INOVA Vision Institute and Autonomous University of Aguascalientes. Pterygium is an important illness that affects 22% people from tropic and equatorial zones. Is an inflammatory process caused by UV rays, and it has a behavior similar to a neoplasm. For this study was taken into consideration 191 samples from the INOVA Vision Institute, Aguascalientes, Mexico. Include 73 pterygia samples, which were obtained during rese… Show more

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Cited by 6 publications
(3 citation statements)
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“…This protein could serve as a natural mechanism of protection against inflammation. 122 The nuclear factor kb (NFkb) pathway has also been found to be activated in human pterygium tissue. In a study conducted with nuclear extracts from pterygium and healthy conjunctiva tissue, higher levels of NF-kb proteins RelA and p50 were found in pterygia.…”
Section: Inflammatory Mediators and Growth Factorsmentioning
confidence: 99%
See 1 more Smart Citation
“…This protein could serve as a natural mechanism of protection against inflammation. 122 The nuclear factor kb (NFkb) pathway has also been found to be activated in human pterygium tissue. In a study conducted with nuclear extracts from pterygium and healthy conjunctiva tissue, higher levels of NF-kb proteins RelA and p50 were found in pterygia.…”
Section: Inflammatory Mediators and Growth Factorsmentioning
confidence: 99%
“…Further inflammatory cascades 31 Phospholipase D Further inflammation and cellular differentiation 121 Cystatin C Regulation of extracellular matrix modulators 122 increase in the expression levels of stem cell factor, 131 platelet-derived growth factor (PDGF), 120 connective tissue growth factor (CTGF), 132 and transforming growth factor-beta (TGF-b) 120 have been documented in pterygium. Inflammatory processes of pterygium can trigger reactive wound formation, which may induce dysregulated and inappropriate tissue remodeling, fibroproliferation, enhanced vascularization, and deposition of the extracellular matrix, leading to the formation of hypertrophic scarring.…”
Section: Cox2mentioning
confidence: 99%
“…It has a central dot for fixation and the edges of the grid subtend 10° when held at a distance of 28–30 cm 12. Whilst the AG is a cheap and accepted method for monitoring patients at risk of developing nvAMD, a wide range of sensitivities for detecting nvAMD has been reported including good to excellent sensitivity1820 as well as sensitivity as poor as chance level 21–23. A recent meta-analysis suggested a pooled sensitivity of 78% (95% CI 64–87%) for detection of nvAMD 24.…”
Section: Why Does the Amsler Grid Require A Successor?mentioning
confidence: 99%