Over-expression of human kallikrein 11 is associated with poor prognosis in patients with low rectal carcinoma

Yu, Xiao; Tang, Hua; Li, Xiao Rong; Xiao, He; Xiang, Kai

doi:10.1007/s12032-009-9167-2

Cited by 17 publications

(11 citation statements)

References 14 publications

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“…Associated with cirrhosis and hepatitis C virus (HCV) infection; inversely associated with hepatitis B virus (HBV) infection ing Dukes' staging, histologic grade, CEA levels, lymph node metastasis, and invasion depth. In fact, weak KLK11 expression predicted a better clinical outcome for low rectal carcinoma patients (38).…”

Section: Association Of Klk Gene Expression With Clinico-pathologicalmentioning

confidence: 99%

Kallikrein-related peptidases (KLKs) in gastrointestinal cancer: Mechanistic and clinical aspects

Kontos¹,

Mavridis²,

Talieri³

et al. 2013

Thromb Haemost

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SummaryThe human tissue kallikrein (KLK1) and kallikrein-related peptidases (KLKs) are secreted serine proteases with diverse expression patterns and physiological roles in different systems, including the digestive system. The aberrant expression of KLKs in gastrointestinal malignancies as well as their implication in carcinogenesis including cell growth regulation, angiogenesis, invasion, and metastasis, has prompted scientists to investigate their potential as cancer biomarkers. Expression of distinct KLKs is associated with various clinic-pathological parameters of patients with gastric, colorectal, pancreatic, hepatic, and esophageal cancer. Moreover, several KLKs possess significant favourable or unfavourable prognostic value in these human malignancies. Identification of novel diagnostic, prognostic and predictive biomarkers will contribute utmost to clinical decision-making, since early diagnosis of gastrointestinal cancer and early detection of recurrence following surgery are critical for the effective treatment of patients and for a positive clinical outcome. The current review provides a brief overview of the functional role of KLKs in gastric, colorectal, pancreatic, hepatic, and esophageal cancer, and describes the current status of KLKs as potential tumour biomarkers in these human malignancies.

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Section: Association Of Klk Gene Expression With Clinico-pathologicalmentioning

confidence: 99%

Kallikrein-related peptidases (KLKs) in gastrointestinal cancer: Mechanistic and clinical aspects

Kontos¹,

Mavridis²,

Talieri³

et al. 2013

Thromb Haemost

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“…Kallikrein-related peptidases 11 (KLK11) is a member of the human kallikrein gene family, which localized on chromosome 19q13.4 [5]. Recent studies have reported that KLK11 has been expressed in many cancers, including prostate cancer [6], ovarian cancer [7], gastric cancer [8], as well as rectal carcinoma [9]. An immunofluorometric assay study demonstrated that KLK11 expression in ovarian cancer tissues is a marker of favorable prognosis, since patients with KLK-positive tumors exhibit a longer progression-free survival (PFS) and overall survival (OS) [10].…”

Section: Introductionmentioning

confidence: 99%

The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer

2014

Tumor Biol.

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The aim of this study was to explore the diagnostic and prognostic value of serum human kallikrein-related peptidases 11 (KLK11) level in non-small cell lung cancer (NSCLC). Serum specimens from 138 patients with NSCLC and 40 healthy controls were collected. The concentration of KLK11 was measured by enzyme-linked immunosorbent assay (ELISA). The concentration of KLK11 in NSCLC was significantly higher compared to that in the controls (P < 0.01). The serum KLK11 levels decreased with stage, presence of lymph node, and distant metastases, regardless of histology, age, and sex. With a cutoff point of 1.05 ng/ml, KLK11 showed a good diagnostic performance for NSCLC. Univariate analysis revealed that NSCLC patients with serum high KLK11 had a longer overall survival (OS) and progression-free survival (PFS) than those with low KLK11 (HR of 0.36, P = 0.002; HR of 0.46, P = 0.009). Cox multivariate analysis indicated that KLK11 was an independent prognostic indicator of PFS and OS (HR of 0.53, P = 0.042; HR of 0.48, P = 0.037). Kaplan–Meier survival curves further confirmed that patients with high KLK11 have longer PFS and OS (P = 0.003 and P = 0.018, respectively). In conclusion, the measurement of KLK11 might be a useful diagnostic and prognostic test for NSCLC patients.

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“…Serine proteases play a role in cascade pathways, such as the blood coagulation cascade, the dissolution of blood clots, the intestinal digestive enzymes, and the apoptosis pathway [ 6 ]. Kallikrein cascade seems to be valuable in elucidation of the various mechanisms underlying cancer invasion and metastasis [ 9 ]. There is evidence of a link between kallikreins and cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported an association between kallikreins and cancer prognosis. Yu et al [ 9 ] reported that over-expression of hK11 was associated with poor prognosis in patients with low rectal carcinoma. Diamandis et al [ 11 ] found that hk11 is an indicator of favorable prognosis in ovarian cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Is Human Kallikrein 11 in Non-small Cell Lung Cancer Treated Chemoradiotherapy Associated with Survival?

et al. 2016

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PurposeInvolvement of human kallikreins (hKs) in human cancers has been reported and several hKs are promising biomarkers of various cancers. The aim of this study was to evaluate the prognostic significance of hK11 expression in patients with non-metastatic non-small cell lung cancer (NSCLC).Materials and MethodsThe study included 44 patients with NSCLC. hK11 expression was determined by immunohistochemical staining.ResultsThe estimation of disease-free and overall survival by Kaplan-Meier was 11 months and 17 months, respectively. The estimation of overall survival by Kaplan-Meier was significantly higher in patients with hK11 strongly positive (2+) than in those with hK11 weakly positive (1+) (20 months vs. 11 months, p=0.032). Although not statistically different, the estimation of disease-free survival by Kaplan-Meier was higher in patients with hK11 strongly positive (2+) than in those with hK11 weakly positive (1+) (12 months vs. 9 months, p=0.113). Multivariate Cox regression analysis showed that the overall survival rates were significantly associated with response to chemoradiotherapy and the degree of staining with hK11.ConclusionThe stronger hK11 expression in NSCLC appears to be associated with better survival rates. hK11 may be a prognostic biomarker of NSCLC.

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Over-expression of human kallikrein 11 is associated with poor prognosis in patients with low rectal carcinoma

Abstract: hK11 may be another prognostic biomarker of LRC. Knowledge of hK11 expression in LRC tissues could contribute to the prediction of prognosis of LRC patients.

Cited by 17 publications

References 14 publications

Kallikrein-related peptidases (KLKs) in gastrointestinal cancer: Mechanistic and clinical aspects

Kallikrein-related peptidases (KLKs) in gastrointestinal cancer: Mechanistic and clinical aspects

The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer

Is Human Kallikrein 11 in Non-small Cell Lung Cancer Treated Chemoradiotherapy Associated with Survival?

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