Over-expression of IGF-related peptides in stenoses of native arteriovenous fistulas in hemodialysis patients

Stracke, Sylvia; Könner, Klaus; Köstlin, Isabella; Schneider, Markus; Herzog, Rosa; Jehle, Peter; Keller, Frieder; Friedl, Reinhard

doi:10.1016/j.ghir.2007.02.001

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…Vascular smooth muscle cells and macrophages and lymphocytes within the stenotic lesions of fistulas in hemodialysis patients are found to be the sources of IGF-related peptides in this study. 4 In addition, insulin resistance assessed by homa has been demonstrated to be an independent predictive factor for CVD, a unit increase in insulin resistance is found to be related with a 5.4% increase in CVD risk. 2 The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA) reported the homa-IR index as the independent predictor of coronary artery calcification.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin-like growth factor-1 (IGF-1) and transforming-growth factor-B are growth factors with local activity which may play a role in the development of intimal hyperplasia. 4,5 The stenosis of AVF can thus be accepted as a model of accelerated vascular atherogenesis. IGF-1 has a role in many vasculopathies, such as hypertension, atherosclerosis, angiogenesis, vascular restenosis, and diabetic vasculopathy.…”

Section: Introductionmentioning

confidence: 99%

“…6 In failing AVF of hemodialysis patients, IGF-1 and IGF-binding proteins-1 immunoreactivity in the neointimal and the medial layers have been demonstrated. 4 The major problem with AVF is the high rate of primary failure, which may be due to early thrombotic event and/or maturation arrest. AVF endothelium is activated by the surgery and exhibits augmented permeability, offering a targeting mechanism for retention in pathological endothelium.…”

Section: Introductionmentioning

confidence: 99%

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A novel factor for primary arteriovenous fistula failure: hyperinsulinism

Akın

Özmen

Kaya³

2016

Renal Failure

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Introduction: Dysfunction of vascular access is an important reason of morbidity for dialysis patients and it is a major factor affecting the economical burden of hemodialysis. The preferred type of vascular access is creation of an arteriovenous fistula (AVF). However, the problem of fistula maturation rate is still a challenge. Herein, we tried to search the role of hyperinsulinism and insulin resistance as a new predictor of primary AVF failure (pAVFF) that may be a cause of intimal damage. Methods: We included 119 patients (73 male and 46 female) with a diagnosis of end-stage renal disease (ESRD) who had undergone an AVF operation by a vascular surgeon. The AVF was examined for presence of thrill on the first postoperative day. A successful cannulation with two fistula needles with a blood flow of 250 mL/min for at least one complete dialysis session, after 4 weeks of AVF surgery was defined as functioning access. Insulin resistance in our patients was determined by the standard homeostasis model assessment (homa-IR). A logistic-regression analysis was performed to investigate the independent factors related with pAVFF. Findings: Detection of pAVFF occurred in 27 (22.7%) patients. The presence of thrill, amount of daily proteinuria, insulin levels, homa-IR, and serum albumin levels were found to be significantly different between patients with fistula failure and those without pAVFF. The logistic-regression analysis of preoperative factors revealed the following OR (odds ratio) and 95% CI values: homa-IR 1.205 (1.063-1.366) (p ¼ 0.004), serum albumin 0.398 (0.178-0.892) (p ¼ 0.025), and the amount of daily proteinuria 1.307 (1.012-1.688) (p ¼ 0.041). Even after addition of the presence of postoperative thrill on AVF, which was a postoperative strong clinical factor to the analysis, mean homa-IR and mean serum albumin continued to be independent predictors of pAVFF. Discussion: Insulin resistance or hyperinsulinism may be a significant cause of pAVFF, which emphasizes the role of endothelium in fistula dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel factor for primary arteriovenous fistula failure: hyperinsulinism

Akın

Özmen

Kaya³

2016

Renal Failure

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“…In contrast, the IGF-IGFBP-ALS complex limits the function of IGF, which must be released from the complex to cross the capillary-endothelial barrier into target tissues [37]. Studies on IGF have shown that it is involved in the migration of human arterial smooth muscle cells (SMCs) [38]; production of nitric oxide in endothelial cells [39,40]; and some vascular diseases, such as stenotic arteriovenous fistula [41], coronary arteriosclerosis [42], carotid artery intima-media thickening [43] and ischaemic heart disease [44]. In addition, considering that the main effect on IGF release was the proteolysis of IGFBP [36] and that it has been demonstrated in an ALS knockout mouse model that ALS plays a critical role in regulating circulating levels of these proteins [37,45], we hypothesized that ALS mainly plays a role in biological function by influencing the formation of the IGF-IGFBP-ALS complex.…”

Section: Discussionmentioning

confidence: 99%

Identified plasma proteins related to vascular structure are associated with coarctation of the aorta in children

Zheng

et al. 2020

Ital J Pediatr

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Background: Coarctation of the aorta (CoA), presenting with local stenosis of the aorta is involved in many cardiovascular processes. However, there has been little research on the mechanism of coarctation of the aorta. Methods: Altered proteins were identified by isobaric tag for relative and absolute quantitation (iTRAQ) technology in 8 participants, and further analysed by heatmap, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) and Search Tool for the Retrieval of Interacting Gene (STRING). Of these, two vascular structure-related proteins were further validated by using enzyme-linked immunosorbent assay (ELISA) in a new cohort of CoA patients. Results: 39 differentially expressed plasma proteins were first identified in patients with coarctation of the aorta by iTRAQ. Of these, fibulin-1 (FBLN1) and insulin-like growth factor-binding protein complex acid labile subunit (ALS) were considered candidates and further validation also showed that the level of FBLN1 in the CoA group (8.92 ± 2.36 μg/ml) was significantly higher compared with control group (6.13 ± 1.94 μg/ml), and the level of ALS in CoA children (348.08 ± 216.74 ng/ml) was significantly lower than the level in normal children (619.46 ± 274.08 ng/ml). Conclusions: The differentially expressed proteins identified in the plasma from CoA patients indicated that they may play critical roles in CoA and that they could potentially be utilized as biomarkers for diagnosis. Altered vascular related proteins were associated with COA. These results provide a foundation for further understanding and studying the aetiology and pathogenesis of coarctation of the aorta.

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“…8 Postoperative IH is a build-up of mostly myofibroblast-like cells (neointimal cells) and extracellular matrix (ECM) within the innermost layer of the fistula wall. 9,10 Occasionally, very few inflammatory cells and contractile smooth muscle cells (SMCs) are also found infiltrated in the intima. 6,11 The development of IH involves diverse and complex signaling cascades that ultimately result in intimal accumulation of myofibroblastic cells.…”

Section: Introductionmentioning

confidence: 99%

The anatomical sources of neointimal cells in the arteriovenous fistula

et al. 2021

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Neointimal cells are an elusive population with ambiguous origins, functions, and states of differentiation. Expansion of the venous intima in arteriovenous fistula (AVF) is one of the most prominent remodeling processes in the wall after access creation. However, most of the current knowledge about neointimal cells in AVFs comes from extrapolations from the arterial neointima in non-AVF systems. Understanding the origin of neointimal cells in fistulas may have important implications for the design and effective delivery of therapies aimed to decrease intimal hyperplasia (IH). In addition, a broader knowledge of cellular dynamics during postoperative remodeling of the AVF may help clarify other transformation processes in the wall that combined with IH determine the successful remodeling or failure of the access. In this review, we discuss the possible anatomical sources of neointimal cells in AVFs and their relative contribution to intimal expansion.

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Over-expression of IGF-related peptides in stenoses of native arteriovenous fistulas in hemodialysis patients

Cited by 5 publications

References 39 publications

A novel factor for primary arteriovenous fistula failure: hyperinsulinism

A novel factor for primary arteriovenous fistula failure: hyperinsulinism

Identified plasma proteins related to vascular structure are associated with coarctation of the aorta in children

The anatomical sources of neointimal cells in the arteriovenous fistula

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