Over‐expression of MSG1 Transcriptional Co‐activator Increases Melanin in B16 Melanoma Cells: A Possible Role for MSG1 in Melanogenesis

Nair, Sujit S.; Chaubal, Vaishali A.; Shioda, Toshi; Coser, Kathryn R.; Mojamdar, Manoj

doi:10.1034/j.1600-0749.2001.140311.x

Cited by 20 publications

(20 citation statements)

References 9 publications

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“…It is well established that the LH surge is closely related to photoperiod in experimental animals (Legan & Karsch 1975, Legan et al 1975, suggesting a possibly similar role for this gene in the regulation of LH secretion. Cited1 has been shown to function as a transcriptional coregulator of estrogen in a manner dependent on ER ligand binding and its interaction with CBP/p300 transcriptional coactivator (Shioda et al 1996, Yahata et al 2000, Nair et al 2001. While its role in the pituitary has yet to be studied in depth, the evidence presented in this study suggests that Cited1 may be a coregulator of ERa in this tissue as well.…”

Section: Cmentioning

confidence: 65%

Identification of estradiol/ERα-regulated genes in the mouse pituitary

Kim¹,

Gieske²,

Trudgen³

et al. 2011

Journal of Endocrinology

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Estrogen acts to prime the pituitary prior to the GnRHinduced LH surge by undiscovered mechanisms. This study aimed to identify the key components that mediate estrogen action in priming the pituitary. RNA extracted from the pituitaries of metestrous (low estrogen) and proestrus (high estrogen) stage mice, as well as from ovariectomized wildtype and estrogen receptor a (ERa) knockout mice treated with 17b-estradiol (E 2 ) or vehicle, was used for gene expression microarray. Microarray data were then aggregated, built into a functional electronic database, and used for further characterization of E 2 /ERa-regulated genes. These data were used to compile a list of genes representing diverse biological pathways that are regulated by E 2 via an ERa-mediated pathway in the pituitary. This approach substantiates ERa regulation of membrane potential regulators and intracellular vesicle transporters, among others, but not the basic components of secretory machinery. Subsequent characterization of six selected genes (Cacna1a, Cacna1g, Cited1, Abep1, Opn3, and Kcne2) confirmed not only ERa dependency for their pituitary expression but also the significance of their expression in regulating GnRH-induced LH secretion. In conclusion, findings from this study suggest that estrogen primes the pituitary via ERa by equipping pituitary cells with critical cellular components that potentiate LH release on subsequent GnRH stimulations.

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Section: Cmentioning

confidence: 65%

Identification of estradiol/ERα-regulated genes in the mouse pituitary

Kim¹,

Gieske²,

Trudgen³

et al. 2011

Journal of Endocrinology

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“…CITED1 was originally identified in a murine melanoma cell line and was shown to be associated with the process of melanogenesis (Shioda et al, 1996;Nair et al, 2001). It was subsequently shown to function as a transcriptional coregulator of both the estrogen receptor and SMAD4 in a manner dependent on either estrogen receptor ligand binding or TGFb induced SMAD dimerization and its interaction with the CBP/p300 transcriptional coactivator Yahata et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis

et al. 2005

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“…CITED1, a transcriptional coactivator belonging to the CITED family, was originally identified in a murine melanoma cell line and implicated in the melanogenesis process (33,40). Members of this family of non-DNA-binding proteins contain a well conserved C-terminal acidic domain that accounts for their strong transcriptional activating activity (40).…”

mentioning

confidence: 99%

An EGR2/CITED1 Transcription Factor Complex and the 14-3-3σ Tumor Suppressor Are Involved in Regulating ErbB2 Expression in a Transgenic-Mouse Model of Human Breast Cancer

Dillon

Brown

Chen

et al. 2007

Molecular and Cellular Biology

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Amplification and elevated expression of the ErbB2 receptor tyrosine kinase occurs in 20% of human breast cancers and is associated with a poor prognosis. We have previously demonstrated that mammary tissuespecific expression of activated ErbB2 under the control of its endogenous promoter results in mammary tumor formation. Tumor development was associated with amplification and overexpression of ErbB2 at both the transcript and protein levels. Here we demonstrate that the EGR2/Krox20 transcription factor and its coactivator CITED1 are coordinately upregulated during ErbB2 tumor induction. We have identified an EGR2 binding site in the erbB2 promoter and demonstrated by chromatin immunoprecipitation assays that EGR2 and CITED1 associate specifically with this region of the promoter. EGR2 and CITED1 were shown to associate, and expression from an erbB2 promoter-reporter construct was stimulated by EGR2 and was further enhanced by CITED1 coexpression. Furthermore, expression of the 14-3-3 tumor suppressor led to downregulation of ErbB2 protein levels and relocalization of EGR2 from the nucleus to the cytoplasm. Taken together, these observations suggest that, in addition to an increased gene copy number and upregulation of EGR2 and CITED1, an elevated erbB2 transcript level involves the loss of 14-3-3, which sequesters a key transcriptional regulator of the erbB2 promoter.

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Over‐expression of MSG1 Transcriptional Co‐activator Increases Melanin in B16 Melanoma Cells: A Possible Role for MSG1 in Melanogenesis

Cited by 20 publications

References 9 publications

Identification of estradiol/ERα-regulated genes in the mouse pituitary

Identification of estradiol/ERα-regulated genes in the mouse pituitary

CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis

An EGR2/CITED1 Transcription Factor Complex and the 14-3-3σ Tumor Suppressor Are Involved in Regulating ErbB2 Expression in a Transgenic-Mouse Model of Human Breast Cancer

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