Over-the-Counter Alkali Agents to Raise Urine pH and Citrate Excretion: A Prospective Crossover Study in Healthy Adults

Canvasser, Noah; River, Marcelino; Bechis, Seth K.; Ingimarsson, Johann P.; Knoedler, John J.; Stern, Karen; Stoughton, Christa L.; Wollin, Daniel; Borofsky, Michael S.; Bhojani, Naeem; Tayeb, Marawan El; Kamphuis, Guido; Leavitt, David; Hsi, Ryan S.; Scotland, Kymora B.

doi:10.1016/j.urology.2022.05.049

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…Laboratory analysis in previous papers demonstrated moderate to high amounts of alkali content for multiple overthe-counter supplements including KSP tabs and Litho Balance (Figure ). [26][27][28] Of particular interest as a potential alkali solution is the common household item, baking soda (ie, sodium bicarbonate). Laboratory tests performed at Litholink/ LabCorp showed that a quarter teaspoon (315 mg) of baking soda provides the highest mean alkali load of 17.4 mEq (Figure).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Alkaline Water: Help or Hype for Uric Acid and Cystine Urolithiasis?

Piedras,

Cumpanas,

McCormac

et al. 2024

Journal of Urology

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Section: Resultsmentioning

confidence: 99%

“…Laboratory analysis in previous papers demonstrated moderate to high amounts of alkali content for multiple over-the-counter supplements including KSP tabs and Litho Balance (Figure). 26-28…”

Section: Discussionmentioning

confidence: 99%

Alkaline Water: Help or Hype for Uric Acid and Cystine Urolithiasis?

Piedras,

Cumpanas,

McCormac

et al. 2024

Journal of Urology

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“…Still, potassium alkali are avoided in some UA stone formers with or at risk for hyperkalemia such as those with CKD. Over-the-counter alkali supplements vary in their cation and alkali content [75], and can raise urine pH in healthy volunteers [76], but their efficacy in UA stone formers has not been tested.…”

Section: Treatment Approach To Type 4 Renal Tubular Acidosis Vs Uric ...mentioning

confidence: 99%

Type 4 renal tubular acidosis and uric acid nephrolithiasis: two faces of the same coin?

Adomako

Maalouf

2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewThe present review summarizes findings of recent studies examining the epidemiology, pathophysiology, and treatment of type 4 renal tubular acidosis (RTA) and uric acid nephrolithiasis, two conditions characterized by an abnormally acidic urine. Recent findingsBoth type 4 RTA and uric acid nephrolithiasis disproportionately occur in patients with type 2 diabetes and/or chronic kidney disease. Biochemically, both conditions are associated with reduced renal ammonium excretion resulting in impaired urinary buffering and low urine pH. Reduced ammoniagenesis is postulated to result from hyperkalemia in type 4 RTA and from insulin resistance and fat accumulation in the renal proximal tubule in uric acid nephrolithiasis. The typical biochemical findings of hyperkalemia and systemic acidosis of type 4 RTA are rarely reported in uric acid stone formers. Additional clinical differences between the two conditions include findings of higher urinary uric acid excretion and consequent urinary uric acid supersaturation in uric acid stone formers but not in type 4 RTA.

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“…Recently, Canvasser et al completed a prospective crossover study measuring pH and citrate exertion in healthy adults given LithoLyte and KSP Tabs. 3 Patients were randomized to which was taken first and were given a 3-day washout between supplements. Dosage dispensed for LithoLyte was 2 packets twice daily (daily total of 40 mEq alkali) and 1 tablet twice daily (daily total 30 mEq alkali) for KSP Tabs.…”

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confidence: 99%