Over-the-Counter Analgesic Use

Broe, Marc E. De; Elseviers, Monique

doi:10.1681/asn.2008101097

Cited by 46 publications

(25 citation statements)

References 24 publications

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“…This was in line with De Broe et al (42) who suggested increased reno-cortical COX 2 expression and prostaglandin E 2 formation after high dose of paracetamol ingestion. It was also supported by Damera et al (24) who added that paracetamol induced sever infl ammation in renal cortical tissue.…”

Section: Discussionsupporting

confidence: 91%

Mechanism of grape seeds extract protection against paracetamol renal cortical damage in male Albino rats

Hafez¹,

Rifaai²,

Elzaher³

2017

BLL

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OBJECTIVE: The aim of the study was to assess the possible protective role of grape seeds extract (GSE) in ameliorating the toxic effects of paracetamol overdose on the rat renal cortical tissue. BACKGROUND: Paracetamol is one of the widely used non-steroidal anti-infl ammatory drugs (NSAIDs). Unfortunately, it was reported as the most common cause of toxic ingestion in the world. Grape seeds extract (GSE) is known to have a strong antioxidant and anti-infl ammatory properties. METHODS: The rats were divided into 4 groups; control group, GSE group, paracetamol group and GSE with paracetamol group. Kidney specimens were processed for biochemical, histological and immunohisto-chemical studies. RESULTS: The study showed marked biological changes in the form of signifi cant increase in serum urea and creatinine levels with signifi cant decrease in renal superoxide dismutase with paracetamol group. Furthermore, Proximal (PCT) and distal convoluted tubules showed marked degeneration, dense nuclear staining, cytoplasmic vacuolization, and partial loss of the brush borders. Most tubules were dilated, irregular and were fi lled with hyaline casts. PCT and DCT showed less PAS reaction and more COX-2 and caspase expression if compared with the control and the GSE groups. Concomitant administration of grape seeds extract with paracetamol revealed a noticeable amelioration of these biochemical and histological changes. Proximal and distal convoluted tubules showed less PAS reaction and more COX 2 and caspase expression if compared with the control and the GSE. Concomitant administration of GSE with paracetamol revealed a noticeable amelioration of these biochemical and histological changes. CONCLUSION: Grape seeds extract provided biochemical and histo-pathological improvement in paracetamol induced renal cortical toxicity. These fi ndings revealed that this improvement was associated with a decrease in oxidative damage and apoptosis (Tab. 1, Fig. 7, Ref. 55). Text in PDF www.elis.sk. KEY WORDS: grape seeds extract, paracetamol, renal cortex and superoxide dismutase.

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Section: Discussionsupporting

confidence: 91%

Mechanism of grape seeds extract protection against paracetamol renal cortical damage in male Albino rats

Hafez¹,

Rifaai²,

Elzaher³

2017

BLL

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“…Almost one-fourth of non-prescribed CHM in Taiwan has been reported to be adulterated (Huang et al, 1997). Prolonged misuse of OTC medications or analgesics were found to be associated with the development of renal impairment, accelerated deterioration of pre-existing CKD, acute renal failure, analgesic nephropathy, and ESRD (Bednar, 2009;Choudhury and Ahmed, 2006;De Broe and Elseviers, 2009;Pinter and Nagy, 1998;Tsai et al, 2009). The use of non-prescribed CHM, a high proportion of which might be adulterated, was associated with the development of CKD in this study.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of chronic kidney disease among users of non-prescribed Chinese herbal medicine in Taiwan

Hsieh

Huang²,

Chen

et al. 2012

Preventive Medicine

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“…In a number of patients with analgesic nephropathy, the uroepithelia can develop transitional cell carcinoma. Analgesic nephropathy can be accurately diagnosed or excluded by computed tomography scanning without contrast media [202]. Even if renal papillary necrosis occurs in patients with analgetic nephropathy, traditional NSAIDs including ibuprofen [203], tolmetin [204], indomethacin [205], benoxaprofen [206], and naproxen [207,208], have been also reported to cause renal papillary necrosis.…”

Section: Nsaids and Risk For Chronic Kidney Diseasementioning

confidence: 99%

Nonsteroidal Anti-Inflammatory Drugs and the Kidney

2010

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Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly patients and those with co-morbibity (e.g., congestive heart failure, liver cirrhosis or chronic kidney disease) and drug combinations (e.g., renin-angiotensin blockers, diuretics plus NSAIDs) may develop acute renal failure. This review summarizes our present knowledge how traditional NSAIDs and selective COX-2 inhibitors may affect the kidney under various experimental and clinical conditions, and how these drugs may influence renal inflammation, water transport, sodium and potassium balance and how renal dysfunction or hypertension may result.

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Over-the-Counter Analgesic Use

Cited by 46 publications

References 24 publications

Mechanism of grape seeds extract protection against paracetamol renal cortical damage in male Albino rats

Mechanism of grape seeds extract protection against paracetamol renal cortical damage in male Albino rats

Increased risk of chronic kidney disease among users of non-prescribed Chinese herbal medicine in Taiwan

Nonsteroidal Anti-Inflammatory Drugs and the Kidney

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