Over-the-counter anti-ageing topical agents and their ability to protect and repair photoaged skin

Bradley, Eleanor; Griffiths, C.E.M.; Sherratt, Michael J.; Bell, Mike; Watson, Rachel

doi:10.1016/j.maturitas.2014.12.019

Cited by 25 publications

(14 citation statements)

References 98 publications

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“…Specifically, botanical extracts are dominant active ingredient exerting preventive functions against skin dehydration or wrinkle formation. However, their efficacies have seemed unclear because a discrepancy exists between in vitro and in vivo . Moreover, botanical extracts were found to be effective for anti‐aging in clinical tests only when they were mixed with peptides and vitamin derivatives into complexes.…”

Section: Discussionmentioning

confidence: 99%

Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double‐blind, and placebo‐controlled study

Kim¹,

Chung²,

Kim

et al. 2017

J of Cosmetic Dermatology

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Section: Discussionmentioning

confidence: 99%

Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double‐blind, and placebo‐controlled study

Kim¹,

Chung²,

Kim

et al. 2017

J of Cosmetic Dermatology

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“…Other than treatment for burns and chronic wounds, skin substitutes were utilized as bioreactors in therapeutics delivery and also as replacement models of the human skin for toxicological testing, speeding up drug development and replacing animal-based tests in many industries (31). Artificial skin models were also tested to investigate the potential benefits of botanical extract in protecting and repairing photoaged skin, with positive result obtained in those particular studies (32)(33)(34). In drug development, in vitro skin models are most commonly used to test for systemically acting drugs application and efficacy testing for drugs at site of action (35).…”

Section: Artificial Skin: Cosmetics and Pharmacokineticsmentioning

confidence: 99%

Potential applications of human artificial skin and electronic skin (e-skin): a review

Saifullah

Sahidayana

MuhamadFarina

et al. 2018

Bioinspired, Biomimetic and Nanobiomaterials

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, +60129336621 There is an ever increasing need to develop artificial skin that can fully mimic the human skin that it replaces. Skin substitute has been commercialized and used in cosmetics and wound healing treatment, with mixed results obtained. Apart from artificial skin, electronic skin (e-skin) is also widely researched because it can be customized into wearable devices. E-skin is commonly characterized by its flexibility and ability to accommodate a large range of sensors in ultrathin films. This paper reviews current development and technology applied to artificial skin and e-skin. First, the basic layers of normal human skin are introduced. Then current development of artificial skin in cosmetics and grafting applications are mentioned in the next section. Latest technology in the fabrication of e-skin and some of its characteristics in different applications are also discussed. Animal ban for cosmetics testing and its positive effects on the development of alternatives to animal testing in experiments are also explained in this paper. Lastly, the current challenges in skin research and recommendations for future application of artificial skin as well as electronic skin are presented. Bioinspired, Biomimetic and Nanomaterials REVIEW PAPER Keywords: biomimetics\biomaterials\biosensors\self-healing\tissue engineering. ice | science ICE Publishing: All rights reserved differentiation (4,5). To date, there is no artificial skin that could completely replace the actual human skin. However, with the recent progress showing, we are in the right track of producing a reliable and robust artificial skin for general usage. Electronic skin (e-skin) employs the use of sensors to detect changes in environment such as pressure, strain, temperature, and humidity. Technological advancement in the development of e-skin means it has potential use in wearable individual-centered health monitoring, sensitive tactile information acquiring, minimally invasive surgery, and prosthetics (6). The thinness and flexibility of e-skin are some factors that make e-skin desirable and convenient to use. Nonetheless, the challenge lies in creating a tactile-sensing simulation with high resolution, high sensitivity, and rapid response similar to the human skin characteristics (7). This is important as information need to be delivered the fastest way possible in order to provide precise real-time data of the subject.

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“…4 However, in recent years, bioactive peptides have emerged as popular anti-ageing agents which have been proven to be capable of stimulating these major components of the extra cellular matrix (ECM). 5,21,22 Computational approaches for bioactive peptide discovery have the potential to greatly accelerate the identification of novel functional ingredients. 23 Artificial intelligence (AI and machine learning methods have been used recently to successfully discover a novel anti-inflammatory ingredient derived from rice 24,25 and a natural peptide with anti-aging properties derived from the pea proteome.…”

Section: Introductionmentioning

confidence: 99%

pep_35E7UW, a natural peptide with cutaneous anti-ageing effects discovered within the Oryza sativa proteome through machine learning

Wall¹

2020

JDC

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Background: The effects of both chronological and exogenous skin ageing have a profound impact on components of the extracellular matrix (ECM), leading to visible changes in appearance over time. Natural ingredients aimed at alleviating and counteracting the effects of cutaneous ageing are of great interest. Here, we investigate the anti-ageing potential ofpep_35E7UW, a peptide within the rice proteome identified by machine learning. Aim: To examine the in vitro and ex vivo efficacy of pep_35E7UWon ECM neosynthesis in human dermal cells and skin explants. Methods: Using machine learning, pep_35E7UW was identified and its anti-ageing effects were evaluated in human dermal fibroblasts (HDF's) and keratinocytes (HaCaTs) by means of cell culture and wound healing assays. This was further assessed by real time qPCR, where the influence on key genes in the collagen and elastin synthesis pathways was examined. Finally, the ex vivo effect of pep_35E7UW was determined by immunostaining of human skin explants. Results: Cell collagen and elastin assays of HDF's treated with pep_35E7UWreported a 32% and 51% increase in each protein respectively. Gene expression analysis determined that pep_35E7UW significantly increased collagen and elastin expression at multiple time points following treatment. Cell migration was significantly increased with pep_35E7UW treatment in the wound healing assay. pep_35E7UW topical application resulted in significant increase in elastin expression (43%) in human skin explants. Conclusion: Here, we demonstrate that pep_35E7UW, an artificial intelligence (AI) discovered peptide, has the capacity to be both an in vitro and ex vivo stimulator of fundamental ECM components. Our results position pep_35E7UWas a functional ingredient for attenuating the effects of cutaneous ageing.

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Over-the-counter anti-ageing topical agents and their ability to protect and repair photoaged skin

Cited by 25 publications

References 98 publications

Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double‐blind, and placebo‐controlled study

Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double‐blind, and placebo‐controlled study

Potential applications of human artificial skin and electronic skin (e-skin): a review

pep_35E7UW, a natural peptide with cutaneous anti-ageing effects discovered within the Oryza sativa proteome through machine learning

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