Over the counter (OTC) artificial tear drops for dry eye syndrome

Pucker, Andrew D.; Ng, Sueko M; Nichols, Jason J.

doi:10.1002/14651858.cd009729.pub2

Cited by 127 publications

(140 citation statements)

References 100 publications

(397 reference statements)

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“…Nelson 1988 found that an unpreserved artificial tear containing 0.1% sodium hyaluronate was effective in improving dry eye symptoms and led to significant improvement in mean tear film osmolarity, break-up times, and conjunctival and corneal staining scores. However, the use of artificial tears has some limitations (Pucker 2016). The composition of natural tears is complex; they consist of water, salts, hydrocarbons, proteins, and lipids for which artificial tears cannot exactly serve as a substitute (Dogru 2011; Quinto 2008).…”

Section: Introductionmentioning

confidence: 99%

Autologous serum eye drops for dry eye

Pan

Angelina

Marrone

et al. 2017

Cochrane Database of Systematic Reviews

100

123

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Section: Introductionmentioning

confidence: 99%

Autologous serum eye drops for dry eye

Pan

Angelina

Marrone

et al. 2017

Cochrane Database of Systematic Reviews

100

123

View full text Add to dashboard Cite

“…19 The review included 43 RCTs examining 3,497 patients with dry eye of various etiologies. The authors concluded that while over-the-counter artificial tears were generally safe, there was considerable uncertainty regarding the form of artificial tears that works best for treating dry eye symptoms.…”

Section: Resultsmentioning

confidence: 99%

“…The uncertainty mainly arose from the included RCTs being too heterogeneous in terms of study characteristics, patient characteristics, and outcomes reported to allow the conduct of informative meta-analyses. 19 …”

Section: Resultsmentioning

confidence: 99%

Gaps in Current Knowledge and Priorities for Future Research in Dry Eye

Saldanha

Dickersin

Hutfless

et al. 2017

Cornea

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Purpose Dry eye, a common, yet under-recognized and evolving field, has few recommended treatment algorithms, mostly based on expert consensus rather than robust research evidence. There are high costs associated with managing dry eye and conducting research to identify effective and safe long-term treatments. To support evidence-based management of dry eye, our purpose was to identify and prioritize important clinical research questions for future clinical research. Methods We translated recommendations from the American Academy of Ophthalmology’s 2013 Preferred Practice Patterns for dry eye into answerable clinical research questions about treatment effectiveness. Clinicians around the world who manage patients with dry eye rated each question’s importance from 0 (not important) to 10 (very important) using a two-round online Delphi survey. We considered questions as “important” if ≥75% of respondents assigned a rating of 6 or more in Round 2. We mapped the identified important clinical research questions to reliable systematic reviews published up to March 2016. Results Seventy-five clinicians from at least 21 countries completed both Delphi rounds. Among the 58 questions, 24 questions met our definition of “important”: 9/24 and 7/24 addressed topical and systemic treatments, respectively. All four questions with the highest 25th percentiles addressed topical treatments. While 6/24 “important” questions were associated with four existing reliable systematic reviews, none of these reviews came to a definitive conclusion about treatment effectiveness. Conclusion We identified gaps pertaining to treatment options for dry eye. Future clinical research on the management of dry eye should strongly consider these prioritized questions.

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“…The collection of these fluids presents the valuable advantage of being non-invasive (urine, saliva, sweat, tears…) or minimally invasive (blood), allowing for multiple collections and the collection of meaningful amounts for the analyses to be performed. On the other hand, these fluids also present challenges, such as the extremely high dynamic range of plasma or serum, where a dozen of proteins represent more than 90% of the protein content; the more laborious procedure to obtain pure blood cell specimens [81]; or the still not standardized collection of fluids like saliva, sweat or tears [82][83][84].…”

Section: Biomarker Discovery In Peripheral Fluidsmentioning

confidence: 99%

Circulating biomarkers in schizophrenia: a proteomics perspective

Santa¹,

Coelho²,

Madeira³

et al. 2017

IJCNMH

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Schizophrenia (SCZ) is one of the most severe and devastating major mental disorders, with an onset typically in late adolescence or early adulthood affecting about 0.5-1.2% of the population worldwide. It is one of the most debilitating medical conditions, with striking socio-economic burden to society due to lost employment and social support that largely surpass direct costs of treatment. SCZ is listed by the World Health Organization (WHO) among the top 20 leading causes of disability worldwide. Its diagnosis is syndromic, based in clinical interviewing and anamnesis, as there is to date no biochemical test to aid in this diagnosis. On the other hand, SCZ treatment is mostly based in antipsychotic drugs which are in several aspects somehow ineffective, and some of these medications have low tolerability with severe side effects. For all these reasons, the current search for new panels of biomarkers is of the utmost importance to aid in the correct diagnosis and stratification of the patients, prognosis, and prediction of treatment effectiveness.In this review, a total of 25 publications on peripheral SCZ biomarkers are presented from proteomics studies performed in body fluids of patients searching for protein markers, and using mass spectrometry. To date such proteomics studies have already been achieved in cerebrospinal fluid (CSF), serum, plasma, peripheral blood cells (namely, mononuclear cells, T-cells and red blood cells), saliva, and sweat, being of paramount importance in the schizophrenia research field, but still lacking validation and clinical translation.In summary, a general overview of the results from these 25 studies, as well as the challenges and future perspectives of the field, are presented and discussed.

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Over the counter (OTC) artificial tear drops for dry eye syndrome

Cited by 127 publications

References 100 publications

Autologous serum eye drops for dry eye

Autologous serum eye drops for dry eye

Gaps in Current Knowledge and Priorities for Future Research in Dry Eye

Circulating biomarkers in schizophrenia: a proteomics perspective

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