Overall accuracy of cervical cytology and clinicopathological significance of LSIL cells in ASC‐H cytology

Abstract

The Pap smear is a good cervical cancer screening method. Although there was no difference in the predictive value for CIN 2+ between LSIL-H and ASC-H, the presence of definite LSIL cells was more predictive of CIN 2+ in younger patients than in older patients.

Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias

“…Conversely, a study that used ASC-H þ as a cut-off point to ascertain the performance for the detection of CIN 2 þ reported SE of 67.9% and SP of 87%. 30 In this study, SE of major or suspicious for invasion colposcopic findings for the detection of CIN 2 þ was moderate (62%), while SP was low (59%). Although these values were different from each other, this difference was not statistically significant, since their confidence interval overlapped.…”

“…Resultados Das 1.571 participantes, um total de 1.154 (73,4%) foram diagnosticadas com neoplasia intraepitelial escamosa cervical de grau 2 ou mais grave (NIC 2 þ ), 114 (7,2%) com adenocarcinoma in situ ou mais grave (AIS þ ), 615 (39,2%) apresentaram células escamosas atípicas de significado indeterminado, quando não se pode excluir lesão intraepitelial de alto grau ou mais grave (ASC-H þ ) e 934 (59,4%) tiveram achados colposcópicos maiores ou suspeitos de invasão. Os valores de S, E, VPP e VPN das ASC-H þ para o diagnóstico de NIC 2 þ e AIS þ foram, respectivamente: 44% (IC 95%: 41-47) e 72% (IC 95%: 67-76), 79% (IC 95%: 77-81) e 79% (IC 95%: 75-83), 88% (IC 95%: 87-90) e 55% (IC 95%: 50-60) e 28% (IC 95%: [26][27][28][29][30][31] A total of 11,999 medical records of patients referred to colposcopy were reviewed. Among them, 1,527 participants were selected for having their final diagnoses settled by histopathological analyses of transformation zone excision (TZE) pieces, 7 by analysis of cold knife conization (CKC) pieces, and 37 with invasive cervical neoplasias diagnosed in the initial biopsy fragment.…”

Diagnostic Test Accuracy Review of Cytology for Squamous Intraepithelial Lesion and Squamous Cell Carcinoma of Uterine Cervix

“…A cervico-vaginal smear, including the conventional smear and liquid-based cytology, is a simple and inexpensive test for the prediction of squamous intraepithelial lesion (SIL) or squamous cell carcinoma (SqCC) of the uterine cervix 1. These tests have contributed to a decrease in the incidence of cervical cancer, especially in geographic areas supported by well-organized screening programs 1.…”

“…A cervico-vaginal smear, including the conventional smear and liquid-based cytology, is a simple and inexpensive test for the prediction of squamous intraepithelial lesion (SIL) or squamous cell carcinoma (SqCC) of the uterine cervix 1. These tests have contributed to a decrease in the incidence of cervical cancer, especially in geographic areas supported by well-organized screening programs 1. Although several studies have reported on the diagnostic accuracy of the cervico-vaginal smear, results showed a wide range of estimated sensitivity compared to the specificity 1234567891011121314151617181920212223242526272829303132333435363738.…”

“…These tests have contributed to a decrease in the incidence of cervical cancer, especially in geographic areas supported by well-organized screening programs 1. Although several studies have reported on the diagnostic accuracy of the cervico-vaginal smear, results showed a wide range of estimated sensitivity compared to the specificity 1234567891011121314151617181920212223242526272829303132333435363738. Because the diagnostic accuracy can be affected by variable factors, including study time, geographic area, and population,1234567891011121314151617181920212223242526272829303132333435363738 it should be fully elucidated based on these standardized parameters, including the diagnostic grades of cytology.…”