Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhao, Jie V.; Huang, Xin; Zhang, Junmeng; Chan, Yap-Hang; Tse, Hung-Fat; Blais, Joseph E.

doi:10.1016/j.tjnut.2023.08.016

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…BBR has the effect of clearing heat, is an anti-inflammatory [ 13 ], and acts in suppressing pain [ 14 ], and AVL has the effect of promoting gastric peristalsis and gastric emptying [ 15 ]. BBR lowers blood sugar [ 16 ], and AVL promotes insulin secretion, effectively controlling blood sugar [ 17 ]. BBR lowers blood lipids [ 18 ], and AVL improves the function of the heart [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota

Cui,

Li,

Zheng

et al. 2024

IJMS

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Berberine (BBR) is used to treat cancer, inflammatory conditions, and so on. But the side effects of BBR causing constipation should not be ignored. In clinical application, the combination of Amomum villosum Lour. (AVL) and BBR can relieve it. However, the effective ingredients and molecular mechanism of AVL in relieving constipation are not clear. A small intestine propulsion experiment was conducted in constipated mice to screen active ingredients of AVL. We further confirmed the molecular mechanism of action of the active ingredient on BBR-induced constipation. Quercetin (QR) was found to be the effective ingredient of AVL in terms of relieving constipation. QR can efficiently regulate the microbiota in mice suffering from constipation. Moreover, QR significantly raised the levels of substance P and motilin while lowering those of 5-hydroxytryptamine and vasoactive intestinal peptide; furthermore, it also increased the protein expression levels of calmodulin, myosin light-chain kinase, and myosin light chain. The use of QR in combination with BBR has an adverse effect-reducing efficacy. The study provides new ideas and possibilities for the treatment of constipation induced by BBR.

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Section: Introductionmentioning

confidence: 99%

Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota

Cui,

Li,

Zheng

et al. 2024

IJMS

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Evaluation of reported claims of sex-based differences in treatment effects across meta-analyses: A meta-research study

Kastrati,

Farina,

Gris

et al. 2024

Preprint

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ImportanceDifferences in treatment effects between men and women may be important across diverse interventions and diseases.ObjectiveWe aimed to evaluate claims of sex-based differences in treatment effects across published meta-analyses.Data SourcesPubMed (searched up to January 17, 2024).Study SelectionPublished meta-analyses of randomized controlled trials (RCTs) that had any mention of sex (male/female) subgroup or related analysis in their abstract.Data Extraction and SynthesisWe determined how many meta-analyses had made claims of sex-based differences in treatment effects. These meta-analyses were examined in depth to determine whether the claims reflected sex-treatment interactions with statistical support or fallacious claims and categorized the frequency of different fallacies. For claims with statistical support, we examined whether they were considered and discussed in UpToDate. Whenever possible, we re-analyzed the p-value for sex-treatment interaction.Main Outcomes and MeasuresNumber of claims with statistical support and fallacious claims; clinical implications of subgroup differences.Results216 meta-analysis articles fulfilled the eligibility criteria. Of them, 99 stated in the abstract that that there was no sex-based difference, and 20 mentioned a sex-based subgroup analysis without reporting results in the abstract. 97 meta-analyses made 115 claims of sex-based differences. Of them, 27 claims across 21 articles had statistical support at p<0.05. 4/27 claims were mentioned in UpToDate, but none led to different recommendations for men and women. 35 articles had 39 fallacious claims where the sex-treatment interaction was not statistically significant (significant effects in one sex (29 claims in 25 articles), larger effects in one sex (7 claims in 7 articles), other (3 claims in 3 articles)). Another 44 articles made claims based on potentially fallacious methods (39 based on meta-regression of percentage of one group and 5 providing the results of only one group), but proper data were unavailable to assess statistical significance.Conclusions and relevanceFew meta-analyses of RCTs make claims of sex-based differences in treatment effects and most of these claims lack formal statistical support. Statistically significant and clinically actionable sex-treatment interactions may be rare.

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Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 2 publications

References 34 publications

Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota

Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota

Evaluation of reported claims of sex-based differences in treatment effects across meta-analyses: A meta-research study

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