Overall Survival and Clinicopathological Characteristics of Patients with Breast Cancer in Relation to the Expression Pattern of HER-2, IL-6, TNF-α and TGF-β1

Abstract

The present study was conducted to investigate the prognostic significance of co-expression patterna of HER-2, IL-6, TNF-a and TGF-β1 in breast cancer, by correlating the number of markers with positive expression with clinicopathological characteristics indicative of tumor progression and overall survival. One hundred thirty consecutive patients with primary breast cancer were prospectively included and evaluated. Serum concentrations of the above markers were measured by ELISA. Median split was used to subdivide patients with marker positive or negative expression. The presence of ≥3 positive markers was independently associated with extended lymph node (>3) involvement (aOR, 11.94, p=0.001) and lymphovascular invasion (aOR, 12.04, p=0.018), increasing the prognostic significance of each marker considered separately. Additional prognostic information regarding survival was also provided; as the number of positive markers increased, a gradually reduction of survival time was observed. In addition, patients with 4 positive markers had significantly shorter survival (25 vs 39 months, p=0.006) and a more than 4 fold increased risk of death (aHR, 4.35, p=0.003) compared to patients with 3 positive markers. Our findings suggest that the coexpression pattern of these four markers could be used clinically as a useful marker for tumor extension and outcome of breast cancer.

TGF-β1 Protein Expression in Non-Small Cell Lung Cancers is Correlated with Prognosis

“…High expression of TGF-β1 protein was corelated with progression, metastasis and poor prognosis of lung cancer patients, These findings DOI:http://dx.doi.org/10.7314/APJCP.2014.15.19.8143 TGF-β1 Protein Expression is Correlated with Prognosis in Non-Small Cell Lung Cancer suggest that TGF-β1 protein expression can be used as an important indicator for evaluating the prognosis of patients with lung cancer, which have been proved as a usefull marker for progression and prognosis of breast cancer (Gregory Tripsianis et al, 2013). However, The molecular mechanism by which TGF-β1 associated with prognosis has not been elucidated, and whether suppressing the secretion of TGF-β1 or antagonizing TGF-β1' effect being a new strategy of antineoplastic treatment in lung cancer patients still needs to be studied.…”

Predictive Factors of Survival Time of Breast Cancer in Kurdistan Province of Iran between 2006-2014: A Cox Regression Approach

“…Breast cancer cells have a distinct epigenomic DNA methylation profile which affects their metastatic potential (Thakur et al, 2014). Recent reports have shown that C-X-C chemokine receptor 4, TNF-α and IL-6 play an important role in metastasis (Tripsianis et al, 2013;Jiyang et al, 2014).…”

Tai Chi Chuan Exercise for Patients with Breast Cancer: A Systematic Review and Meta-Analysis

“…The present results showed that there were no significant changes in the levels of IL-6, in agreement with previous studies [ 28 ]. Markers of inflammation cytokines, including IL-6 and IL-8, are expressed at high levels in the tumor microenvironment as well as during and after radiation and chemotherapy for breast cancer [ 29 , 30 ]. IL-6 is rapidly produced by contracting skeletal muscle fibers and plays an important role in expression of anti-inflammatory myokines by inhibiting proinflammatory cytokine expression during regular exercise [ 31 , 32 ].…”