Overall survival of patients with colon cancer and a prolonged time to surgery

Abstract

Background Factors associated with the time to surgery (TTS) and survival in colon cancer (CC) have not been well studied. Our aim was to find if the TTS has changed in our institution over time and to determine if it influences the survival. Methods Retrospective cross‐section study of 266 CC analyzed between two periods, and according to the quartiles of TTS, we performed a survival analysis. Results The median age was 57 years; there was no predominance of sex, and about half of the patients were in stage III. The median TTS was 38 days, and 75% of the cases were operated before 60 days. The median TTS for 2005 to 2010 was 36 days, while for 2011 to 2015 was 41 days (P = 0.107). The survival was not statistically different between cases (1) operated with a delayed TTS or not, (2) operated in four cut‐off points of TTS, (3) two different periods of attention, and (4) according to the clinical stage. Conclusion We did not find an association between the TTS with low survival. TTS has increased in the last period so we must work to make the diagnostic process more efficient in our patients to meet international quality standards.

BVES‐AS1 inhibits the malignant behaviors of colon adenocarcinoma cells via regulating BVES

“…Colon adenocarcinoma (COAD) is the third most frequent cancer and the second main cause of cancer‐related death around the world and therefore has become a major public health problem (Cappell, 2008). Although great advances have been achieved on COAD treatment, the 5‑year survival rate of COAD patients still remains remarkably low (Lino‐Silva et al, 2019). As a result, it is urgent to study the molecular mechanism underlying the progression of COAD to develop novel and effective therapeutic strategies.…”

The Association Between Treatment Interval and Survival in Patients With Colon or Rectal Cancer: A Systematic Review

“…In other studies, the definition of the time point used as diagnosis differed. One study used the date of the first investigation defining malignancy [ 24 ], while some studies used date of colonoscopy or first specialist consultation as the date of diagnosis [ 21 , 23 , 30 ]. Others used the date of confirmed pathological diagnosis as date of ‘diagnosis’ [ 25 ].…”

“…In the remaining studies, median follow-up ranged from 2.4 to 5.4 years. Outcome in the majority of the studies (7 out of 10) was overall survival (OS) [ 21 – 24 , 26 , 27 , 30 ], two studies reported on relative survival (RS) [ 29 , 31 ], one study reported on all-cause death (ACD) and cancer-specific death (CSD) [ 25 ], and one study used cancer-specific mortality (CSM) [ 28 ]. Cancer-free survival (CFS) as an outcome was reported in four studies [ 24 , 30 , 31 ].…”

“…Quality scores ranged between 16 and 22. The greatest differences were seen in the items concerning reporting, ranging from a lowest score of six [ 22 , 27 ] to a highest score of ten [ 23 , 30 ], as well as in the items about confounding, ranging from a score of two [ 21 ] to a score of four [ 29 , 30 ] (see Table 2 ).…”

“…(2020) 7 3 4 3 1 18 Grass et al (2020) [ 26 ] 7 3 4 3 1 18 Kaltenmeier el al. (2019) [ 22 ] 6 3 4 3 1 17 Kucejko et al (2020) [ 27 ] 6 3 4 3 1 17 Lino Silva et al (2019) [ 21 ] 7 3 4 2 1 17 Wanis et al (2017) [ 24 ] 8 3 4 3 1 19 Gort et al (2010) [ 31 ] 8 3 4 3 1 19 Pruitt et al (2013) [ 25 ] 6 3 3 3 1 16 Redaniel et al (2014) [ 29 ] 8 3 …”