Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment

Abstract

Symptoms are common among patients receiving treatment for advanced cancers, 1 yet are undetected by clinicians up to half the time. 2 There is growing interest in integrating electronic patient-reported outcomes (PROs) into routine oncology practice for symptom monitoring, but evidence demonstrating clinical benefit has been limited. 3 We assessed overall survival associated with electronic patient-reported symptom monitoring vs usual care based on follow-up from a randomized clinical trial. 4 Methods | The study was approved by the Memorial Sloan Kettering institutional review board and written informed consent was obtained from participants. Consecutive patients initiating routine chemotherapy for metastatic solid tumors at Memorial Sloan Kettering Cancer Center in New York between September 2007 and January 2011 were invited to participate in a randomized clinical trial. Participants were randomly assigned either to the usual care group or to the PRO group, in which patients provided self-report of 12 common symptoms from the National Cancer Institute's Common Terminology Criteria for Adverse Events at and between visits via a web-based PRO questionnaire platform. Participation was continuous until cessation of cancer treatment, voluntary withdrawal from the trial, transition to hospice care, or death. When the PRO group participants reported a severe or worsening symptom, an email alert was triggered to a clini

Baseline Edmonton Symptom Assessment System and Survival in Metastatic Renal Cell Carcinoma

“…When acted on by the health care team, pros were shown to enhance quality of life for patients receiving outpatient treatment for advanced cancers. In an updated analysis of that study 13 , patients who used the Web tool to self-report symptoms, compared with patients who received usual care, experienced longer median overall survival.…”

Patient-Reported Outcome Measures in Routine Clinical Care: The PROMise of a Better Future?

“…In a recently published trial in patients receiving cancer treatment, patients who submitted PROM data through a Web-based platform had better survival outcomes when compared with patients who did not submit PROM data. The authors inferred that the routine integration of PROMs data into routine clinical care for these patients was therefore beneficial to patient survival [8].…”

Relevance of a Mobile Internet Platform for Capturing Inter- and Intrasubject Variabilities in Circadian Coordination During Daily Routine: Pilot Study (Preprint)

“…The multidimensional platform and its capabilities to combine electronic Patient-Reported Outcomes (PROs) with circadian rhythm monitoring and body weight measures meet the expectations of the American Society for Clinical Oncology, regarding the future of e-Health technologies in cancer medicine [52]. Thus, the weekly transmission of electronic PROs significantly improved overall survival in two randomized trials conducted in cancer patients, indicating this information might elicit initially unplanned interventions and/or modify patient's engagement with an oncologic benefit equivalent to that of the addition of an active drug [53,54]. The PiCADo platform provides a novel framework for the further integration of circadian rhythms and other parameters into proactive timely care interventions and the ready assessment of their efficacy.…”