Overcoming addiction stigma: Epigenetic contributions to substance use disorders and opportunities for intervention

Szutorisz, Henrietta; Hurd, Yasmin L.

doi:10.1016/j.neuron.2022.03.018

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2024

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Cited by 7 publications

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“…Epigenetics describes the heritable reversible alterations in gene expression without changing the nucleotide sequences [ 5 ]. Epigenetics primarily encompasses histone modifications, DNA methylation and non-coding RNAs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Histone modifications in cocaine, methamphetamine and opioids

Cheng

Chen

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

Histone modifications in cocaine, methamphetamine and opioids

Cheng

Chen

et al. 2023

Heliyon

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Parental Exposure to Morphine Before Conception Decreases Morphine and Cocaine‐Induced Locomotor Sensitization in Male Offspring

Heidari,

Hajikarim‐Hamedani,

Hosseindoost

et al. 2024

Developmental Psychobiology

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Repeated exposure to abused drugs leads to reorganizing synaptic connections in the brain, playing a pivotal role in the relapse process. Additionally, recent research has highlighted the impact of parental drug exposure before gestation on subsequent generations. This study aimed to explore the influence of parental morphine exposure 10 days prior to pregnancy on drug‐induced locomotor sensitization. Adult male and female Wistar rats were categorized into morphine‐exposed and control groups. Ten days after their last treatment, they were mated, and their male offspring underwent morphine, methamphetamine, cocaine, and nicotine‐induced locomotor sensitization tests. The results indicated increased locomotor activity in both groups after drug exposure, although the changes were attenuated in morphine and cocaine sensitization among the offspring of morphine‐exposed parents (MEPs). Western blotting analysis revealed altered levels of D2 dopamine receptors (D2DRs) in the prefrontal cortex and nucleus accumbens of the offspring from MEPs. Remarkably, despite not having direct in utero drug exposure, these offspring exhibited molecular alterations affecting morphine and cocaine‐induced sensitization. The diminished sensitization to morphine and cocaine suggested the development of a tolerance phenotype in these offspring. The changes in D2DR levels in the brain might play a role in these adaptations.

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