Overcoming Antibiotic Resistance in Helicobacter Pylori: The Promise of Non-Antibiotic Therapies

Abstract

Helicobacter pylori (H. pylori) infection, a widespread global health concern, has traditionally been tackled with combinations of antibiotics and proton pump inhibitors (PPIs). While effective, these treatment regimens are frequently costly, complex, and replete with side effects. The rising tide of antibiotic-resistant H. pylori strains further clouds the long-term reliability of such antibiotic-focused approaches, making it imperative to explore alternative strategies. This article illuminates the promising frontier of non-antibiotic treatments, featuring exciting prospects like probiotics, herbal extracts, certain foods, antimicrobial peptides, and traditional Chinese medicine. This burgeoning field presents a fresh opportunity to circumnavigate antibiotic resistance, optimize eradication rates, and revitalize our fight against H. pylori. Our comprehensive analysis of the latest strides in non-antibiotic treatments strives to spotlight effective, safe, and patient-centric approaches that could bolster our arsenal against H. pylori. By highlighting these new-age solutions, we hope to stimulate further research and catalyse the development of personalized, innovative treatments for H. pylori infections, redefining its management in a sustainable way.