Overcoming Barriers for Clinical Research of Acupuncture

Liu, Wenli; Cohen, Lorenzo

doi:10.1089/acu.2020.1480

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…As reflected by our data, there's increasing interest in applying acupuncture in head and neck cancer [38,72,85]. Although a detailed description is not within the scope of this work, our findings indirectly confirm the shortcomings bound with performing clinical research in the field of acupuncture [50,[86][87][88]. In spite of the methodological rigorousness based on a PICO-literature search, the large heterogeneity found in the retrieved data restrained us from providing any definitive recommendation on the role of acupuncture in the field of HNSCC.…”

Section: Discussionsupporting

confidence: 74%

Acupuncture for radiation-induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria

Bonomo

Stocchi

Caini

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose In head and neck squamous cell carcinoma (HNSCC), the potential mitigating effect of complementary medicine interventions such as acupuncture for radiation-induced toxicity is unknown. This study aimed to assess the impact of acupuncture on the incidence and degree of severity of common radiation-induced side effects. Methods In accordance with pre-specified PICO criteria, a systematic review was performed. Two electronic databases (Medline and Embase) were searched over a 10-year time frame (01/01/10 to 30/09/20). Patients undergoing a curatively intended, radiation-based treatment for histologically confirmed squamous cell carcinoma of the nasopharynx, oropharynx, larynx, hypopharynx and oral cavity represented the target population of our study. Accurate information on the acupuncture methodology was reported. All included articles were evaluated to identify any potential source of bias Results Five papers were included in our qualitative analysis, for a total of 633 subjects. Compliance to per-protocol defined schedule of acupuncture sessions was high, ranging from 82 to 95.9%. Most patients (70.6%) were randomly allocated to receive acupuncture for its potential preventive effect on xerostomia. The large heterogeneity in study settings and clinical outcomes prevented from performing a cumulative quantitative analysis, thus no definitive recommendations can be provided. Conclusions Although shown to be feasible and safe, no firm evidence currently supports the use of acupuncture for the routine management of radiation-induced toxicity in HNSCC.

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Section: Discussionsupporting

confidence: 74%

Acupuncture for radiation-induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria

Bonomo

Stocchi

Caini

et al. 2021

Eur Arch Otorhinolaryngol

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“…Consequently, explanatory clinical trials have been unable to establish the exact efficacy of acupuncture 5. The methodology of acupuncture clinical trials has been continuously discussed, and researchers have tried to report reliable results for decision-makers 6 7. Alternatively, pragmatic acupuncture trials designed to evaluate the effectiveness of acupuncture treatments in real-world practice conditions have been conducted, and several studies have tried to show clinical benefits of acupuncture over conventional treatments even though the mechanism and specific efficacy could not be verified 8…”

Section: Introductionmentioning

confidence: 99%

Applying the PRECIS-2 tool for self-declared ‘pragmatic’ acupuncture trials: protocol for a systematic review

2022

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IntroductionThe pragmatic design has received much attention in the field of acupuncture clinical trials because of insufficient information about the specific effects of acupuncture. However, pragmatism in pragmatic acupuncture trials has not been comprehensively investigated. The PRECIS-2 tool was developed and has been gradually used to design pragmatic trials; therefore, we will apply the PRECIS-2 tool to investigate the pragmatism of pragmatic acupuncture trials in this study.Methods and analysisIn this systematic review, self-declared ‘pragmatic’ randomised clinical trials (RCTs) or protocols of self-declared ‘pragmatic’ RCTs investigating acupuncture will be searched and included to be reviewed. MEDLINE, EMBASE, the Cochrane Central Register for Controlled Trials, CINAHL, Allied and Complementary Medicine Database (AMED), China National Knowledge Infrastructure, VIP, WANFANG, Taiwan Periodical Literature Database, KoreaMed, KMbase, Research Information Service System, Oriental Medicine Advanced Searching Integrated System, CiNii and ClinicalTrials.gov for registered trials will be electronically searched from inception to March 2022. Protocols of published RCTs or secondary analysis of RCTs will be excluded. Additionally, no language restriction will be applied. Two authors will independently extract descriptive information and assess the pragmatism of pragmatic acupuncture trials using nine domains of the PRECIS-2 tool and one additional domain—control. Descriptive statistics will be reported for each domain and the overall score, and a one-sample t-test will be used to statistically analyse whether the score is greater than 3 (equally pragmatic and explanatory). The wheel diagrams of the nine domains of the PRECIS-2 tool will be used to demonstrate the pragmatism of the included studies.Ethics and disseminationEthical approval is not warranted as this study will obtain data from previously reported articles. The results will be disseminated through peer-reviewed journals and conferences.PROSPERO registration numberCRD42021236975.

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Advances in neural mechanisms related to acupuncture sensation

Xiao

Chen

Feng

et al. 2022

Tradit. Med. Mod. Med.

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Pinching at specific areas of the human body will produce special sensations, such as soreness, numbness, heaviness and distention, which are collectively referred to as acupuncture sensation. The generation of acupuncture sensation, linked to a variety of receptors and nerve endings in different acupoint areas, induces nerve impulses that are transmitted to the central system through the spinal cord in different patterns. Sensory areas in the cerebral cortex are processed and transformed the impulses to form special sensations. This paper will systematically review the mechanisms of these sensations in different situations, and compare acupuncture sensations to review and analyze the mechanism of acupuncture effect.

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Overcoming Barriers for Clinical Research of Acupuncture

Cited by 5 publications

References 30 publications

Acupuncture for radiation-induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria

Acupuncture for radiation-induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria

Applying the PRECIS-2 tool for self-declared ‘pragmatic’ acupuncture trials: protocol for a systematic review

Advances in neural mechanisms related to acupuncture sensation

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