Overcoming male factor infertility with intracytoplasmic sperm injection

Borges, Edson; Zanetti, Bianca Ferrarini; Braga, Daniela Paes de Almeida Ferreira; Setti, Amanda Souza; Figueira, Rita de Cássia Sávio; Nardi, Aguinaldo Cesar; Iaconelli, Assumpto

doi:10.1590/1806-9282.63.08.697

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…81.48%, compared to 63.24% for PCOS (P<0.0001) (Okohue et al, 2013). Borges et al documented no difference in pregnancy outcomes between male infertility and tubal infertility; it was also reported that ICSI leads to better results in male factors (Borges Jr et al, 2017). Aboulghar et al indicated a significant difference in egg fertilization rate between IVF and ICSI methods in patients with borderline semen.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Success Rates by Different Assisted Reproductive Techniques in Tubal, Ovarian, and Sperm Disorders

Hafezabad

Gohari

Kashi

2020

JCCNC

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Background: Assisted Reproductive Techniques (ART) have been used for addressing numerous causes of infertility. However, it remains unclear which kind of these methods are best for various infertility types. Accordingly, this study aimed at determining pregnancy success rates by different ART in tubal, ovarian, and sperm disorders. Methods: The present descriptive retrospective study used the records of individuals who had referred to the Infertility Center of Kerman University of Medical Sciences from March 2016 to December 2017. All subjects underwent Intracytoplasmic Sperm Injection (ICSI) and In Vitro Fertilization (IVF). The sperm parameters were assessed based on the criteria of the World Health Organization (WHO) for determining the causes of male infertility. The data were documented and compared with the criteria of the WHO. Then, they were analyzed by analysis of variance, Paired Samples t-test, Chi-squared, or Fisher’s Exact tests using SPSS. Results: The overall Mean±SD fertility rate in IVF and ICSI was 4.28±2.87 and 3.62±2.54, respectively and the difference was not significant (t=1.02, P=0.319). There was a significant difference in the fertility rate due to tubal infertility (P=0.018) between ICSI and IVF; the fertility rate in the IVF method was significantly higher than that of the ICSI. The pregnancy rate in the freeze method was higher than those of the other methods (P<0.001). This discrepancy was also found in all causes of infertility. There was no significant difference in the disorders of sperm and the result of two methods (IVF/ICSI). Conclusion: The obtained results suggested that in the freeze method, the pregnancy rate was higher than other approaches; this discrepancy was found in all the causes of infertility. It is suggested that frozen-thawed embryo transfer be used in infertile individuals. This is because it increases the success rate of pregnancy and prevents complications due to the repeated use of infertility treatments and exorbitant treatment costs.

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Section: Discussionmentioning

confidence: 99%

Pregnancy Success Rates by Different Assisted Reproductive Techniques in Tubal, Ovarian, and Sperm Disorders

Hafezabad

Gohari

Kashi

2020

JCCNC

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“…In the course of analysing the studies that are consistent with the deleterious effect of female age, it was verified once again that increasing female age decreased the mean number of retrieved oocytes (Pinto et al, 2009;Maman et al, 2012;Ramezanzadeh et al, 2012;O'Brien et al, 2017;Sahin et al, 2021), embryo quality (Ramezanzadeh et al, 2012;Bocca et al, 2017), embryo cleavage rate (Ramezanzadeh et al, 2012), FR (O'Brien et al, 2017, biochemical pregnancy rate (BPR) (O'Brien et al, 2017), CPR (Kovacs et al, 2003;Shen et al, 2003;Pinto et al, 2009;Huang et al, 2012;Maman et al, 2012;Berger et al, 2014;Coelho Neto et al, 2015;Nouri et al, 2015;Meijerink et al, 2016;Amsiejiene et al, 2017;Bocca et al, 2017;Hassan et al, 2017;O'Brien et al, 2017;McPherson et al, 2018;Peuranpää et al, 2020) and LBR (Nelson & Lawlor, 2011;Hamdine et al, 2015;Nouri et al, 2015;McPherson et al, 2018;Peuranpää et al, 2020;Wen et al, 2021), and was associated to poor response cycles (Maman et al, 2012), higher cancellation rate (Borges et al, 2017), higher miscarriage rate (Peuranpää et al, 2020;Sahin et al, 2021) and higher risk of macrosomia (Nelson & Lawlor, 2011). On the other hand, other studies showed no or mixed outcomes with female age such as ...…”

Section: Female Agementioning

confidence: 90%

“…We also reviewed papers that studied female age along with other variables. Most demonstrated the trend expected (Shen et al, 2003;Kovacs et al, 2003;Pinto et al, 2009;Nelson & Lawlor, 2011;Huang et al, 2012;Maman et al, 2012;Ramezanzadeh et al, 2012;Berger et al, 2014;Hamdine et al, 2015;Coelho Neto et al, 2015;Nouri et al, 2015;Meijerink et al, 2016;Amsiejiene et al, 2017;Bocca et al, 2017;Hassan et al, 2017;McPherson et al, 2018;Peuranpää et al, 2020), but others found no or a varied relationship between female age and IVF/ICSI (Busnelli et al, 2014;Chen et al, 2015;Lefebvre et al, 2015;Niinimäki et al, 2015;Borges et al, 2017;Reljič et al, 2017).…”

Section: Female Agementioning

confidence: 91%

“…Recently, within a cohort of couples experiencing IVF/ICSI, those with male factor infertility had slightly increased chances of success compared to those without (Wen et al, 2021). Moreover, as no significant differences in the rates of pregnancy and miscarriage were observed when comparing couples with male or tubal factor, but FR and IR were higher, results further suggest that ICSI can surpass male factor infertility limitations (Borges et al, 2017). The main relationships of sperm parameters with these ART outcomes are resumed in Table 6.…”

Section: The Predictive Value Of Conventional Sperm Parametersmentioning

confidence: 99%

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In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes

Ribeiro¹,

Sousa²

2022

JBRA

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The development of assisted reproductive technology has allowed offspring in infertile couples, and specifically, allowed infertile men to conceive through Intracytoplasmic Sperm Injection (ICSI). Despite the proven efficacy of In Vitro Fertilisation (IVF) and ICSI, many factors can influence its success. In this review we present an analysis on the effect of Female age, Ovarian Reserve, Male age and Male factor on the outcomes of IVF/ICSI, to determine if and which can be applied to the practical context. A literature search on PubMed, EMBASE and MEDLINE for relevant articles was elaborated until July 2021, leading to the selection of 234 articles based on their titles. After reading through the abstracts, those that evaluated IVF/ ICSI predicting factors were selected. Finally, only those approaching female age, ovarian reserve, male age and male factor were considered in this review. Higher female age and baseline ovarian markers alterations such as lower anti-Müllerian hormone and antral follicular count, and higher basal follicle-stimulating hormone, were associated with poorer outcomes. The predictive value of Male age and Male factor presented varied results across literature. The multifactorial nature of male fertility makes evaluation difficult. Although the first assessment of male infertility is based on sperm concentration, motility and morphology, semen parameters have shown low prognostic value, whilst sperm DNA alterations gain importance. Nevertheless, results remain controversial. While some factors have proven to predict IVF/ICSI success, other need to be further studied to be applied to practical context to allow the best prognosis possible.

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Impact of short abstinence versus testicular sperm on sperm DNA fragmentation: a systematic review and meta-analysis

Kugelman,

Hochberg,

Dahan

2024

Arch Gynecol Obstet

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Overcoming male factor infertility with intracytoplasmic sperm injection

Cited by 5 publications

References 34 publications

Pregnancy Success Rates by Different Assisted Reproductive Techniques in Tubal, Ovarian, and Sperm Disorders

Pregnancy Success Rates by Different Assisted Reproductive Techniques in Tubal, Ovarian, and Sperm Disorders

In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes

Impact of short abstinence versus testicular sperm on sperm DNA fragmentation: a systematic review and meta-analysis

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