Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo

Li, Shuyi; Li, Chan; Jin, Shubin; Liu, Juan; Xue, Xiangdong; Eltahan, Ahmed Shaker; Sun, Jiadong; Tan, Jingjie; Dong, Jinchen; Liang, Xing‐Jie

doi:10.1016/j.biomaterials.2017.08.021

Cited by 84 publications

(45 citation statements)

References 29 publications

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“…Recently, a wide variety of biodegradable polymers has been studied for the co-delivery of several anticancer drugs, including those based on Pt(II) drugs. [266][267][268] It should also be noted a gratype polypeptide micellar system for the combined drug delivery (Fig. 41).…”

Section: Metallopolymers For Combination Therapymentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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Section: Metallopolymers For Combination Therapymentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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“…According to the authors, this decrease could be justified by the antioxidant activity in the organism, becoming able to modify the in vivo antioxidant capacity of cells present in plasma and blood. In vitro and in vivo studies by Li et al 45 demonstrated strong evidence that GST inhibitor modified prodrugs combined with nanoparticles significantly enhanced antitumor effects against cisplatin-resistant cancer. Fig.…”

Section: Enzymatic Studiesmentioning

confidence: 99%

Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties

et al. 2018

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Beta-carotene is a carotenoid precursor of vitamin A, known for its biological activities. Due to its high hydrophobicity, nanonization processes, i.e. the transformation into nanoparticles, can improve its water affinity, and therefore the activity in aqueous systems. The objective of this study was to produce beta-carotene nanoparticles by the solid dispersion method and to evaluate their effects on the activity of glutathione-S-transferase and acetylcholinesterase enzymes using Drosophila melanogaster (DM) homogenate, the superoxide dismutase- and catalase-like activities under in vitro conditions, and their cytotoxic properties against tumor and non-tumor cells. The formed nanometric beta-carotene particles resulted in stable colloids, readily dispersed in water, able to modulate acetylcholinesterase (AChE) activity, and presenting high potential to control the cholinergic system. Beta-carotene nanoparticles, at concentrations much lower than the pure pristine beta-carotene, presented in vitro mimetic activity to superoxide dismutase and altered glutathione-S-transferase activity in DM tissue. The content of hydrogen peroxide was neither affected by the nanoparticles (in aqueous solution) nor by pristine beta-carotene (in DMSO). In the cytotoxic assays, beta-carotene nanoparticles dispersed in water showed activity against four different tumor cell lines. Overall, beta-carotene nanoparticles presented significant bioactivity in aqueous medium surpassing their high hydrophobicity constraint.

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“…Another common mechanism of chemoresistance involves glutathione s-transferase (GST) overexpression, an enzyme that typically protects against reactive electrophiles and DNA damage (26). When overexpressed in cancer, GST has been shown to increase chemoresistance, possibly by catalyzing the binding of glutathione to chemotherapy drugs to minimize their effects, preventing drugs from attacking DNA, or deactivating cisplatin, a common platinum-based component of many chemotherapies that targets DNA in cancer cells (6,27,28).…”

Section: Genetic and Functional Adaptation Toward Cell-autonomous Chementioning

confidence: 99%

Extracellular Vesicles and Chemotherapy Resistance in the AML Microenvironment

et al. 2020

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Extracellular vesicle (EV) trafficking provides for a constitutive mode of cell-cell communication within tissues and between organ systems. Different EV subtypes have been identified that transfer regulatory molecules between cells, influencing gene expression, and altering cellular phenotypes. Evidence from a range of studies suggests that EV trafficking enhances cell survival and resistance to chemotherapy in solid tumors. In acute myeloid leukemia (AML), EVs contribute to the dynamic crosstalk between AML cells, hematopoietic elements and stromal cells and promote adaptation of compartmental bone marrow (BM) function through transport of protein, RNA, and DNA. Careful analysis of leukemia cell EV content and phenotypic outcomes provide evidence that vesicles are implicated in transferring several known key mediators of chemoresistance, including miR-155, IL-8, and BMP-2. Here, we review the current understanding of how EVs exert their influence in the AML niche, and identify research opportunities to improve outcomes for relapsed or refractory AML patients.

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Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo

Cited by 84 publications

References 29 publications

Recent advances in metallopolymer-based drug delivery systems

Recent advances in metallopolymer-based drug delivery systems

Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties

Extracellular Vesicles and Chemotherapy Resistance in the AML Microenvironment

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