Overcoming the challenges of infrared photosensitizers in photodynamic therapy: the making of redaporfin

Arnaut, Luis; Pereira, Mariette M.

doi:10.1039/d3cc02283h

Cited by 12 publications

(2 citation statements)

References 85 publications

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“…Redaporfin, a synthetic bacteriochlorin, is an anticancer agent also known as LUZ11 or F-2BMet [ 20 , 44 ]. While redaporfin is approved as an orphan drug by the EMA for the treatment of cholangiocarcinoma, it is not yet approved for the treatment of head and neck cancer [ 45 ].…”

Section: Head and Neck Cancermentioning

confidence: 99%

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

Kim,

Chang

2023

Pharmaceutics

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Photodynamic therapy (PDT) is an emerging and less invasive treatment modality for various types of cancer. This review provides an overview of recent trends in PDT research, ranging from basic research to ongoing clinical trials, focusing on different cancer types. Lung cancer, head and neck cancer, non-melanoma skin cancer, prostate cancer, and breast cancer are discussed in this context. In lung cancer, porfimer sodium, chlorin e6, and verteporfin have shown promising results in preclinical studies and clinical trials. For head and neck cancer, PDT has demonstrated effectiveness as an adjuvant treatment after surgery. PDT with temoporfin, redaporfin, photochlor, and IR700 shows potential in early stage larynx cancer and recurrent head and neck carcinoma. Non-melanoma skin cancer has been effectively treated with PDT using methyl aminolevulinate and 5-aminolevulinic acid. In prostate cancer and breast cancer, PDT research is focused on developing targeted photosensitizers to improve tumor-specific uptake and treatment response. In conclusion, PDT continues to evolve as a promising cancer treatment strategy, with ongoing research spanning from fundamental investigations to clinical trials, exploring various photosensitizers and treatment combinations. This review sheds light on the recent advancements in PDT for cancer therapy and highlights its potential for personalized and targeted treatments.

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Section: Head and Neck Cancermentioning

confidence: 99%

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

Kim,

Chang

2023

Pharmaceutics

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“…Photodynamic therapy (PDT), a clinically approved method that involves light-triggered photosensitizers (PSs) to generate cytotoxic reactive oxygen species (ROS) for tumor cell eradication, has great potential in treating various malignant tumors because of its high spatiotemporal accuracy, negligible drug resistance and non-invasiveness. 1 Until now, some PSs have been used in the clinic to treat oncological patients. 2 Nevertheless, the short excitation wavelengths (<700 nm) of these PSs unavoidably attenuate the treatment effect for deep-seated tumors.…”

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confidence: 99%

An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics

Wang,

Wang

et al. 2024

Chem. Commun.

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Porphyrin Atropisomerism as a Molecular Engineering Tool in Medicinal Chemistry, Molecular Recognition, Supramolecular Assembly, and Catalysis

Maguire,

Strachan,

Norvaiša

et al. 2024

Chemistry A European J

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Porphyrin atropisomerism, which arises from restricted σ‐bond rotation between the macrocycle and a sufficiently bulky substituent, was identified in 1969 by Gottwald and Ullman in 5,10,15,20‐tetrakis(o‐hydroxyphenyl)porphyrins. Henceforth, an entirely new field has emerged utilizing this transformative tool. This review strives to explain the consequences of atropisomerism in porphyrins, the methods which have been developed for their separation and analysis and present the diverse array of applications. Porphyrins alone possess intriguing properties and a structure which can be easily decorated and molded for a specific function. Therefore, atropisomerism serves as a transformative tool, making it possible to obtain even a specific molecular shape. Atropisomerism has been thoroughly exploited in catalysis and molecular recognition yet presents both challenges and opportunities in medicinal chemistry.

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Overcoming the challenges of infrared photosensitizers in photodynamic therapy: the making of redaporfin

Abstract: We offer a personal account of the discovery and development of a photosensitizer for photodynamic therapy (PDT) of cancer, from bench to bedside. We emphasize the more chemical aspects of...

Cited by 12 publications

References 85 publications

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics

Porphyrin Atropisomerism as a Molecular Engineering Tool in Medicinal Chemistry, Molecular Recognition, Supramolecular Assembly, and Catalysis

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