2017
DOI: 10.2174/1567201813666160816105408
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Overcoming the Challenges of siRNA Delivery: Nanoparticle Strategies

Abstract: Delivery of siRNA to the target site is the biggest challenge for its application in the clinic. The findings of this review confirmed by encapsulation siRNA in the nanoparticles can overcome these challenges. The rapid progress in nanotechnology has enabled the development of effective nanoparticles as the carrier for siRNA delivery. However, our data about siRNA-based therapeutics and also nanomedicine are still limited. More clinical data needs to be completely understood in the benefits and drawbacks of si… Show more

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Cited by 53 publications
(29 citation statements)
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“…However, unforeseen challenges related with siRNA stability and the need to reach high doses to render biological efficacy after i.v. administration, prompted us to choose an alternative strategy [34]. Thus, we attempted to block SMC2 activity by specific interaction with an antibody against the protein.…”
Section: Discussionmentioning
confidence: 99%
“…However, unforeseen challenges related with siRNA stability and the need to reach high doses to render biological efficacy after i.v. administration, prompted us to choose an alternative strategy [34]. Thus, we attempted to block SMC2 activity by specific interaction with an antibody against the protein.…”
Section: Discussionmentioning
confidence: 99%
“…Despite RNAi being a very efficient mechanism, siRNAs are poorly deliverable in vivo as naked molecules, primarily because of low stability in the bloodstream due to degradation by RNases as well as low cell and tissue permeability 2, 3, 4, 5, 6. Nevertheless, there is increasing interest in the development of efficient siRNA carriers 7, 8, 9, 10, 11…”
Section: Introductionmentioning
confidence: 99%
“…NNMs are intended to increase the therapeutic index of drugs (i.e., increase efficacy and/or reduce toxicity) by delivering them via various mechanisms: solubilization, passive targeting, active targeting, and triggered release (Figure 1 ). Nanoencapsulation gives the opportunity to protect fragile compounds that degrade easily in biological environments and to provide solubilization, i.e., to deliver compounds which have physicochemical properties that strongly limit their aqueous solubility and therefore systemic bioavailability (Talekar et al, 2015 ; Kim et al, 2016 ; Larsson et al, 2017 ; Mishra et al, 2017 ; Shajari et al, 2017 ). Targeted drug delivery and triggered release of NNMs have been shown to be beneficial for increasing the therapeutic index of compounds, by improving the in vivo fate of drug molecules such that more efficient delivery to the target site is achieved (to yield improved therapeutic effects) with less accumulation in many healthy body sites (to reduce toxicity).…”
Section: Introductionmentioning
confidence: 99%