Overcoming tumor microenvironment obstacles: Current approaches for boosting nanodrug delivery

Wang, Xiaohui; Zhang, Hong; Chen, Xiaohui; Wu, Chunrong; Ding, Ke; Sun, Guan; Luo, Yang; Xiang, Dingcheng

doi:10.1016/j.actbio.2023.05.043

Cited by 30 publications

(8 citation statements)

References 252 publications

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“…The abnormal structure of tumor blood vessels could hinder the effective delivery of immune cells and therapeutic drugs, thereby affecting the efficacy of tumor treatment. 38–40 The aforementioned experiments have confirmed that the US thermal effect could effectively dilate the blood vessels inside the tumor. It is expected that this vascular dilation can promote the accumulation of PLD and anti-PD-L1 in tumor tissues and the infiltration of T lymphocytes.…”

Section: Resultsmentioning

confidence: 68%

Ultrasound -Induced Thermal Effect Enhances the Efficacy of Chemotherapy and Immunotherapy in Tumor Treatment

Xiang,

Tang,

Pang

et al. 2024

IJN

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Section: Resultsmentioning

confidence: 68%

Ultrasound -Induced Thermal Effect Enhances the Efficacy of Chemotherapy and Immunotherapy in Tumor Treatment

Xiang,

Tang,

Pang

et al. 2024

IJN

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“…It should be pointed out that the PA signals were primarily distributed within the superficial tumor tissues, which may be attributed to the abundant blood vessels in superficial region of solid tumors. To improve the penetration ability of BT‐NS NPs, promising strategies include employing physical interventions to alter interstitial fluid pressure, as well as implementing chemical modifications to enhance targeting efficacy [20] …”

Section: Resultsmentioning

confidence: 99%

“…As anticipated, the intensity of implementing chemical modifications to enhance targeting efficacy. [20] The ex vivo NIR-II FLI of main organs at 96 h postinjection offered solid fact for the good tumor retention effect of BT-NS NPs. Besides, obvious fluorescent signals were seen in the liver and spleen, revealing the metabolic pathway of BT-NS NPs was primarily through the hepatobiliary system (Figure 5C and Figure S36).…”

Section: Methodsmentioning

confidence: 99%

Thiophene π‐Bridge Manipulation of NIR‐II AIEgens for Multimodal Tumor Phototheranostics

Gui,

Wang,

Wang

et al. 2024

Angew Chem Int Ed

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The fabrication of a multimodal phototheranostic platform on the basis of single‐component theranostic agent to afford both imaging and therapy simultaneously, is attractive yet full of challenges. The emergence of aggregation‐induced emission luminogens (AIEgens), particularly those emit fluorescence in the second near‐infrared window (NIR‐II), provides a powerful tool for cancer treatment by virtue of adjustable pathway for radiative/non‐radiative energy consumption, deeper penetration depth and aggregation‐enhanced theranostic performance. Although bulky thiophene π‐bridges such as ortho‐alkylated thiophene, 3,4‐ethoxylene dioxythiophene and benzo[c]thiophene are commonly adopted to construct NIR‐II AIEgens, the subtle differentiation on their theranostic behaviours has yet to be comprehensively investigated. In this work, systematical investigations discovered that AIEgen BT‐NS bearing benzo[c]thiophene possesses acceptable NIR‐II fluorescence emission intensity, efficient reactive oxygen species generation, and high photothermal conversion efficiency. Eventually, by using of BT‐NS nanoparticles, unprecedented performance on NIR‐II fluorescence/photoacoustic/photothermal imaging‐guided synergistic photodynamic/photothermal elimination of tumors was demonstrated. This study thus offers useful insights into developing versatile phototheranostic systems for clinical trials.

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“…[ 137 ] Simultaneously, interstitial fluid pressure (IFP) increases drastically due to severe vascular leakage and poor lymphatic drainage. [ 138 ] Therefore, extracellular barriers are often considered bottlenecks, as they determine whether NPs can extravasate from the vasculature and penetrate the tumor parenchyma. [ 139 ]…”

Section: Functional Engineering Strategies Of Bndsmentioning

confidence: 99%

Boosting Checkpoint Immunotherapy with Biomimetic Nanodrug Delivery Systems

Chen,

Tang,

Chen

et al. 2024

Adv Healthcare Materials

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Immune checkpoint blockade (ICB) has achieved unprecedented progress in tumor immunotherapy by blocking specific immune checkpoint molecules. However, the high biodistribution of the drug prevents it from specifically targeting tumor tissues, leading to immune‐related adverse events. Biomimetic nanodrug delivery systems (BNDSs) readily applicable to ICB therapy have been widely developed at the preclinical stage to avoid immune‐related adverse events. By exploiting or mimicking complex biological structures, the constructed BNDS as a novel drug delivery system has good biocompatibility and certain tumor‐targeting properties. Herein, we highlight the latest findings regarding the aforementioned therapies associated with ICB therapy. Simultaneously, prospective bioinspired engineering strategies can be designed to overcome the four‐level barriers to drug entry into lesion sites. In future clinical translation, BNDS‐based ICB combination therapy represents a promising avenue for cancer treatment.This article is protected by copyright. All rights reserved

show abstract

Overcoming tumor microenvironment obstacles: Current approaches for boosting nanodrug delivery

Cited by 30 publications

References 252 publications

Ultrasound -Induced Thermal Effect Enhances the Efficacy of Chemotherapy and Immunotherapy in Tumor Treatment

Ultrasound -Induced Thermal Effect Enhances the Efficacy of Chemotherapy and Immunotherapy in Tumor Treatment

Thiophene π‐Bridge Manipulation of NIR‐II AIEgens for Multimodal Tumor Phototheranostics

Boosting Checkpoint Immunotherapy with Biomimetic Nanodrug Delivery Systems

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