This study investigates the relationships between stock price, stock trading volume, and bid-ask spread for 45 firms on the US stock market. To study the nature, extent, and direction of these relationships, we used the Johansen co-integration test, the Vector Error Correction Model (VECM), and the Vector Autoregressive Model (VAR).The analysis indicated that in 62% of the firms, price and volume were co-integrated in the sense that they had a long-run positive equilibrium relationship. On the other hand, the majority of firms showed no relationship between price and spread or volume and spread. In 73% of the firms, there was no relationship between price and spread. Also, 78% of the firms showed no relationship between volume and spread. There was little evidence for co-integration between price and spread or volume and spread. Price and spread were co-integrated in only three firms and volume and spread in two firms.Of interest was the fact that the group of firms that showed a co-integrated relationship between price and volume had group means for return on equity (ROE), return on equity per share, (ROE-S) and return on assets (ROA) that were twice as high as those for the group of firms where volume and price were not related. Also, they had a smaller group mean for total debt to assets ratio than the firms with no relationship between price and volume. These financial ratios are of importance in investment. They give investors the ability to assess a company's financial structure and determine if the company is a suitable investment. Hence, they could be a driving force behind the co-integrated relationship between price and volume.