Overcrowding factors of mosquito larvae. VI. Structure-activity relations of 2-substituted aliphatic carboxylic acids against mosquito larvae

Overcrowding factors of mosquito larvae. VIII. Structure-activity relationship of methyl 2-alkylalkanoates against mosquito larvae

“…As in the case of 2-alkylalkanoic acids (Hwang et al, 1974b), the biological activity of the methyl 2-alkylalkanoates was significantly influenced by the molecular weight of the compounds.…”

“…Figures 2-4 show comparative biological activity of methyl 2-ethylalkanoates, methyl 2-butylalkanoates, and methyl 2-hexylalkanoates with their corresponding 2alkylalkanoic acids (Hwang et al, 1974b). In every case, the esters were more active than the corresponding acids.…”

“…Investigations on the biological activity of various branched-chain carboxylic acids revealed that 2-and 3alkylalkanoic acids manifested a high level of activity (Ikeshoji and Mulla, 1974b;Hwang et al, 1974a). Systematic studies on the structure-activity relationship of 2-alkylalkanoic acids showed that 2-ethyl-, 2-butyl-, and 2-hexylalkanoic acids with a total number of carbon atoms from 14 to 18 generally exhibited good activity (Hwang et al, 1974b). Some of the analogues of the overcrowding factors show good biological activity in the range of 0.5-5 parts per million (ppm) (Hwang et al, 1974a(Hwang et al, ,b, 1976; Ikeshoji and Mulla, 1974b), whereas the effective rates of petroleum oils routinely used for mosquito control are in the order of 20-50 ppm (Hagstrum and Mulla, 1968).…”

Insecticidal activity of alkanamides against immature mosquitoes

“…Previously, we reported that 2-ethyl, 2-butyl, and 2hexylalkanoic acids having even numbers of carbon atoms and a total number of carbon atoms from 14 to 18 generally showed a moderate degree of activity (Hwang et al, 1974b).…”

Silver-Catalyzed Decarboxylative Azidation of Aliphatic Carboxylic Acids

“…1-Azido-3,5-dimethyladamantane (2b) 6 The reaction of 3,5-dimethyladamantane-1-carboxylic acid 1b (62. 5 2.70 (m, 1H), 1.26 (dd, J =6.4 Hz, 1.6 Hz, 3H); 13 C NMR: (100 MHz, CDCl 3 ) δ 137. 7, 129.3, 128.5, 126.7, 59.0, 42.5, 19.1.…”