2014
DOI: 10.1001/jamainternmed.2013.12738
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Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer

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Cited by 679 publications
(559 citation statements)
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“…Consistent with this, those cancers most likely to be overdiagnosed are prostate cancer, from prostate-specific antigen testing of asymptomatic men in primary care; breast cancer, from organised mammography screening; thyroid cancer, from ultrasound of the thyroid and/or adjoining structures; and lung cancer, from screening smokers using computed tomography. 7,10,13,[19][20][21] Discussing overdiagnosis is good science, not an accusation of malpractice It is the nature of science to change: a scientific attitude entails scepticism and openness to questioning. Overdiagnosis in cancer screening has become topical because, within the science of cancer, it has become increasingly clear that some cancers do not need to be found, and that the benefit/harm balance of screening is less favourable than originally hoped.…”
mentioning
confidence: 99%
“…Consistent with this, those cancers most likely to be overdiagnosed are prostate cancer, from prostate-specific antigen testing of asymptomatic men in primary care; breast cancer, from organised mammography screening; thyroid cancer, from ultrasound of the thyroid and/or adjoining structures; and lung cancer, from screening smokers using computed tomography. 7,10,13,[19][20][21] Discussing overdiagnosis is good science, not an accusation of malpractice It is the nature of science to change: a scientific attitude entails scepticism and openness to questioning. Overdiagnosis in cancer screening has become topical because, within the science of cancer, it has become increasingly clear that some cancers do not need to be found, and that the benefit/harm balance of screening is less favourable than originally hoped.…”
mentioning
confidence: 99%
“…A further potential harm, not yet accounted for in the above calculation, is overdiagnosis. A recent analysis of the NLST data indicates that more than 18% of all lung cancers detected by LDCT may be indolent, and that for one life saved (i.e., out of 320 individuals screened), the expected number of cases of overdiagnosis is 1.38 (33).…”
Section: Discussionmentioning
confidence: 99%
“…[35] Chest X-ray would be taken in order to see if there are any masses in the lungs. [36] explains special techniques such as Computed Tomography (CT) scans or Magnetic Resonance Imaging (MRI) that provide more precise information about the possibility, size, shape and location of any tumours. A new radiology technique which combines the Positron Emission Tomography with CT (PET-CT) aids to provide more accurate details about tumour progression and to diagnose lung tumour better.…”
Section: Physical Examination and Initial Testsmentioning
confidence: 99%