Overexpressed mitogen-and stress-activated protein kinase 1 promotes the resistance of cytarabine in acute myeloid leukemia through brahma related gene 1-mediated upregulation of heme oxygenase-1

Zhang, Siyu; Pan, Chengyun; Shang, Qin; Wang, Weili; Hu, Tianzhen; Liu, Ping; Chen, Siyu; Wang, Jishi; Fang, Qin

doi:10.1016/j.ejphar.2021.174722

Cited by 1 publication

(2 citation statements)

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“…High expression of HO-1 is believed to be a leading factor for drug resistance. MSK1, in turn, has been shown to positively regulate HO-1 through BRG1 (the ATPase subunit of SWI/SNF) (Zhang et al 2022). BRG1 remodels nucleosomes to create Z-DNA, which induces HO-1 gene expression and, therefore, decreases the sensitivity of AML cells to cytarabine (Ara-C), the main drug in AML treatment (Ge et al 2017;Zhang et al 2022).…”

Section: Msk and Liquid Tumorsmentioning

confidence: 99%

“…MSK1, in turn, has been shown to positively regulate HO-1 through BRG1 (the ATPase subunit of SWI/SNF) (Zhang et al 2022). BRG1 remodels nucleosomes to create Z-DNA, which induces HO-1 gene expression and, therefore, decreases the sensitivity of AML cells to cytarabine (Ara-C), the main drug in AML treatment (Ge et al 2017;Zhang et al 2022). The authors observed a positive correlation between the expression of MSK1 and BRG1 in the AML cells, which allowed them to conclude that MSK1 might regulate BRG1 expression.…”

Section: Msk and Liquid Tumorsmentioning

confidence: 99%

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Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states

Sattarifard

Safaei

Khazeeva

et al. 2023

Biochem. Cell Biol.

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The mitogen- and stress-activated protein kinases (MSK) are epigenetic modifiers that regulate gene expression in normal and disease cell states. MSK1 and 2 are involved in a chain of signal transduction events bringing signals from the external environment of a cell to specific sites in the genome. MSK1/2 phosphorylate histone H3 at multiple sites, resulting in chromatin remodeling at regulatory elements of target genes and the induction of gene expression. Several transcription factors (RELA of NF-κB, CREB) are also phosphorylated by MSK1/2 and contribute to induction of gene expression. In response to signal transduction pathways, MSK1/2 can stimulate genes involved in cell proliferation, inflammation, innate immunity, neuronal function, and neoplastic transformation. Abrogation of the MSK-involved signaling pathway is among the mechanisms by which pathogenic bacteria subdue the host’s innate immunity. Depending on the signal transduction pathways in play and the MSK-targeted genes, MSK may promote or hinder metastasis. Thus, depending on the type of cancer and genes involved, MSK overexpression may be a good or poor prognostic factor. In this review, we focus on mechanisms by which MSK1/2 regulate gene expression, and recent studies on their roles in normal and diseased cells.

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Section: Msk and Liquid Tumorsmentioning

confidence: 99%