Overexpressing of caveolin-1 in mesenchymal stem cells promotes deep second-degree burn wound healing

Wu, Zhi‐Ying; Zhu, Min; Mou, Xiaoxin; Ye, Liyue

doi:10.1016/j.jbiosc.2020.11.010

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…In the qRT-PCR findings, the expression levels of Akt and mTOR transcripts were higher [ 42 ]. Overexpression of caveolin-1, the structural component of the caveolae membrane important in cell signaling, improved the efficacy of BD-MSCs and decreased serum levels of IL-1, IL-6, and TNF-α [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Mesenchymal Stem Cells in Burn Wound Management

Surowiecka

Chrapusta²,

Klimeczek-Chrapusta³

et al. 2022

IJMS

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Mesenchymal stem cells have a known regenerative potential and are used in many indications. They secrete many growth factors, including for fibroblasts (FGF), endothelium (VEGF), as well as 14 anti-inflammatory cytokines, and they stimulate tissue regeneration, promoting the secretion of proteins and glycosaminoglycans of extracellular matrices, such as collagen I, II, III, and V, elastin, and also metalloproteinases. They secrete exosomes that contain proteins, nucleic acids, lipids, and enzymes. In addition, they show the activity of inactivating free radicals. The aim of this study was an attempt to collect the existing literature on the use of stem cells in the treatment of a burn wound. There were 81 studies included in the analysis. The studies differed in terms of the design, burn wound model, source of stem cells, and methods of cellular therapy application. No major side effects were reported, and cellular therapy reduced the healing time of the burn wound. Few case reports on human models did not report any serious adverse events. However, due to the heterogeneity of the evidence, cellular therapy in burn wound treatment remains an experimental method.

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Section: Methodsmentioning

confidence: 99%

Mesenchymal Stem Cells in Burn Wound Management

Surowiecka

Chrapusta²,

Klimeczek-Chrapusta³

et al. 2022

IJMS

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Advanced electrospun hydrogel fibers for wound healing

Wang

et al. 2021

Composites Part B: Engineering

115

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Bacterial cellulose as an ideal potential treatment for burn wounds: A comprehensive review

Jabbari,

Babaeipour

2024

Wound Repair Regeneration

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Burn wound regeneration is a complex process, which has many serious challenges such as slow wound healing, secondary infection, and inflammation. Therefore, it is essential to utilise appropriate biomaterials to accelerate and guide the wound healing process. Bacterial cellulose (BC), a natural polymer synthesised by some bacteria, has attracted much attention for wound healing applications due to its unique properties including excellent physicochemical and mechanical properties, simple purification process, three‐dimensional (3D) network structure similar to extracellular matrix, high purity, high water holding capacity and significant permeability to gas and liquid. BC's lack of antibacterial activity significantly limits its biomedical and tissue engineering application, but adding antimicrobial agents to it remarkably improves its performance in tissue regeneration applications. Burn wound healing is a complex long‐lasting process. Using biomaterials in wound treatment has shown that they can satisfactorily accelerate wound healing. The purpose of this review is to elaborate on the importance of BC‐based structures as one of the most widely used modern wound dressings in the treatment of burn wounds. In addition, the combination of various drugs, agents, cells and biomolecules with BC to expand its application in burn injury regeneration is discussed. Finally, the main challenges and future development direction of BC‐based structures for burn wound repair are considered. The four most popular search engines PubMed/MEDLINE, Science Direct, Scopus and Google Scholar were used to help us find relevant papers. The most frequently used keywords were bacterial cellulose, BC‐based biocomposite, wound healing, burn wound and vascular graft.

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Overexpressing of caveolin-1 in mesenchymal stem cells promotes deep second-degree burn wound healing

Cited by 5 publications

References 35 publications

Mesenchymal Stem Cells in Burn Wound Management

Mesenchymal Stem Cells in Burn Wound Management

Advanced electrospun hydrogel fibers for wound healing

Bacterial cellulose as an ideal potential treatment for burn wounds: A comprehensive review

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