Overexpressing PTTG Family Genes Predict Poor Prognosis in KIRC

Abstract

Background: Pituitary tumor transforming genes (PTTG1, PTTG2 and PTTG3P) play a key role in the pathogenesis and development of human cancers. Studies show that overexpression of the PTTG genes is associated with tumor progression and migration. However, little is known about the function of the PTTG genes in the prognostic value of renal clear cell carcinoma (KIRC).Methods: the expression and survival data for KIRC patients were mined from ONCOMINE, UALCAN, Human Protein Atlas, TCGAportal, GEPIA2, Metascape，cBioPortal databases and STRING.Results: PTTG1, 2, and 3P mRNA and protein expression was upregulated in KIRC patients compared to normal tissues, and higher expression levels of PTTG family genes were associated with shorter overall survival (OS). what's more, overexpression of the PTTG family genes has been found to correlate with individual cancer stages and pathological tumor grades. In addition, 18% of mutations in the PTTG family genes were associated with short-term survival in patients with KIRCConclusions: we found that a single PTTG genes or PTTG family genes as a whole may be a potential prognostic biomarker for KIRC.