Overexpression and clinical relevance of the RNA helicase DHX15 in hepatocellular carcinoma

Xie, Chengrong; Liao, Hongfeng; Zhang, Changmao; Zhang, Sheng

doi:10.1016/j.humpath.2018.10.006

Cited by 18 publications

(27 citation statements)

References 21 publications

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“…demonstrated that DHX15 acts as a co-activator of androgen receptor (AR) and promotes prostate cancer progression by enhancing AR transcriptional activity. DHX15 is upregulated and shows a significant correlation with poor prognosis in hepatocellular carcinoma 11 . These studies suggest that DHX15 plays a context-specific role in cancer progression.…”

Section: Introductionmentioning

confidence: 64%

“…DHX15 is known as an ATP-dependent RNA helicase involved in the antiviral response and ribosome biogenesis 6 , 7 . DHX15 is dysregulated in several types of cancers such as glioma, prostate cancer, and hepatocellular carcinoma 9, 10, 11. The function of DHX15 in tumor progression depends on the cellular context.…”

Section: Discussionmentioning

confidence: 99%

“…The function of DHX15 in tumor progression depends on the cellular context. In particular, DHX15 acts as a tumor suppressor in glioma, 9 but as an oncogene in prostate cancer 11 . Although the role of DHX15 in NSCLC is still elusive, several other members of the DEXD/H box helicase family have been shown to participate in NSCLC progression.…”

Section: Discussionmentioning

confidence: 99%

“…DHX15 has been documented to modulate gene expression by repressing CMTR1-dependent mRNA cap formation 8 . Recent reports have indicated the role of DHX15 in cancer progression 9, 10, 11. For instance, Ito et al 9 .…”

Section: Introductionmentioning

confidence: 99%

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Long Non-coding RNA JHDM1D-AS1 Interacts with DHX15 Protein to Enhance Non-Small-Cell Lung Cancer Growth and Metastasis

Yao

Chen

et al. 2019

Molecular Therapy - Nucleic Acids

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JHDM1D antisense 1 (JHDM1D-AS1), a long non-coding RNA (lncRNA), has been shown to promote pancreatic cancer growth by inducing an angiogenic response. However, its biological and clinical significance in non-small-cell lung cancer (NSCLC) is still unclear. In this study, we examined the expression and prognostic significance of JHDM1D-AS1 in NSCLC. The effects of JHDM1D-AS1 knockdown or overexpression on NSCLC growth and metastasis were investigated. We show that JHDM1D-AS1 is upregulated in NSCLC relative to adjacent normal lung tissues. High JHDM1D-AS1 expression is significantly correlated with advanced tumor, node, and metastasis (TNM) stage and lymph node metastasis. JHDM1D-AS1 expression serves as an independent prognostic factor for overall survival of patients with NSCLC. Functionally, JHDM1D-AS1 knockdown inhibits NSCLC cell aggressiveness both in vitro and in vivo, which is rescued by ectopic expression of JHDM1D-AS1. JHDM1D-AS1 binding stabilizes DHX15 protein in NSCLC cells. DHX15 overexpression enhances NSCLC cell proliferation and invasion, whereas knockdown of DHX15 exerts opposite effects. JHDM1D-AS1-mediated aggressive phenotype is impaired when DHX15 is silenced. Ectopic expression of DHX15 restores the defects in proliferation and invasion of JHDM1D-AS1-depleted NSCLC cells. Collectively, the interaction between JHDM1D-AS1 and DHX15 accounts for NSCLC growth and metastasis. This work provides potential additional therapeutic targets for treatment of NSCLC.

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Section: Introductionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long Non-coding RNA JHDM1D-AS1 Interacts with DHX15 Protein to Enhance Non-Small-Cell Lung Cancer Growth and Metastasis

Yao

Chen

et al. 2019

Molecular Therapy - Nucleic Acids

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“…Chemotherapy and radiotherapy are the main treatments for HCC with multiple side effects [8,9]. HCC has high metastasis and recurrence rates [10]. Therefore it is an urgent need to develop other potential treatments to combat this disease.…”

Section: Introductionmentioning

confidence: 99%

KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma

Sun

Shi

et al. 2020

Analytical Cellular Pathology

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Liver cancer is thought as the most common human malignancy worldwide, and hepatocellular carcinoma (HCC) accounts for nearly 90% liver cancer. Due to its poor early diagnosis and limited treatment, HCC has therefore become the most lethal malignant cancers in the world. Recently, molecular targeted therapies showed great promise in the treatment of HCC, and novel molecular therapeutic targets is urgently needed. KIF15 is a microtubule-dependent motor protein involved in multiple cell processes, such as cell division. Additionally, KIF15 has been reported to participate in the growth of various types of tumors; however, the relation between KIF15 and HCC is unclear. Herein, our study investigated the possible role of KIF15 on the progression of HCC and found that KIF15 has high expression in tumor samples from HCC patients. KIF15 could play a critical role in the regulation of cell proliferation of HCC, which was proved by in vitro and in vivo assays. In conclusion, this study confirmed that KIF15 could be a novel therapeutic target for the treatment of HCC.

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RNA splicing: a dual-edged sword for hepatocellular carcinoma

Kashyap

Tripathi

et al. 2022

Med Oncol

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Overexpression and clinical relevance of the RNA helicase DHX15 in hepatocellular carcinoma

Cited by 18 publications

References 21 publications

Long Non-coding RNA JHDM1D-AS1 Interacts with DHX15 Protein to Enhance Non-Small-Cell Lung Cancer Growth and Metastasis

Long Non-coding RNA JHDM1D-AS1 Interacts with DHX15 Protein to Enhance Non-Small-Cell Lung Cancer Growth and Metastasis

KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma

RNA splicing: a dual-edged sword for hepatocellular carcinoma

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