Overexpression miR‐211‐5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating <scp>SOX</scp>11

Wang, Lei; Shen, Yidi; Shi, Zhimin; Shang, Xianwen; Jin, Dayong; Xiao, Feng

doi:10.1002/jcla.22293

Cited by 42 publications

(34 citation statements)

References 46 publications

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“…In melanoma, overexpression of miR-211 reduces the cell proliferation, migration, and invasion ( Mazar et al, 2010 , 2016 ). Besides, miR-211 is downregulated in thyroid tumor and overexpression of miR-211 hinders the proliferation, migration, and invasion of thyroid tumor cells ( Wang et al, 2017c ). Meanwhile, in vitro and in vivo studies reveal that upregulation of miR-211 suppresses the migration and invasion in renal cancer ( Wang et al, 2017a ).…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis

Yang

Zheng

Xue

et al. 2018

Front. Mol. Neurosci.

115

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Glioblastoma (GBM) is the most aggressive and malignant primary tumor. Angiogenesis plays a critical role in the progression of GBM. Previous studies have indicated that long non-coding RNAs (lncRNAs) are abnormally expressed in various cancers and participate in the regulation of the malignant behaviors of tumors. The present study demonstrated that lncRNA antisense 1 to Micro-chromosome maintenance protein 3-associated protein (MCM3AP-AS1) was upregulated whereas miR-211 was downregulated in glioma-associated endothelial cells (GECs). Knockdown of MCM3AP-AS1 suppressed the cell viability, migration, and tube formation of GECs and played a role in inhibiting angiogenesis of GBM in vitro. Furthermore, knockdown of MCM3AP-AS1 increased the expression of miR-211. Luciferase reporter assay implicated that miR-211 targeted KLF5 3′-UTR and consequently inhibited KLF5 expression. Besides, in this study we found that MCM3AP-AS1 knockdown decreased KLF5 and AGGF1 expression by upregulating miR-211. In addition, KLF5 was associated with the promoter region of AGGF1. Knockdown of KLF5 decreased AGGF1 expression by transcriptional repression, and also inhibited the activation of PI3K/AKT and ERK1/2 signaling pathways. Overall, this study reveals that MCM3AP-AS1/miR-211/KLF5/AGGF1 axis plays a prominent role in the regulation of GBM angiogenesis and also serves as new therapeutic target for the anti-angiogenic therapy of glioma.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis

Yang

Zheng

Xue

et al. 2018

Front. Mol. Neurosci.

115

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“…In Wang et al research, miR-211 was found to arrest cell cycle, suppress proliferation and invasion of thyroid tumor cells [26]. Chen et al uncovered the antitumor effect of miR-211-5p on breast cancer cells through suppression of cell proliferation, invasion, migration and metastasis by targeting SET binding protein 1 (SETBP1) [16].…”

Section: Discussionsupporting

confidence: 46%

“…The antitumor role of miR-211 in vitro and in vivo was proved by abundant studies [16,26,27]. In Wang et al research, miR-211 was found to arrest cell cycle, suppress proliferation and invasion of thyroid tumor cells [26].…”

Section: Discussionsupporting

confidence: 42%

Ligustrazine Inhibits Growth, Migration and Invasion of Medulloblastoma Daoy Cells by Up-Regulation of miR-211

Chi

Li³

2018

Cell Physiol Biochem

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Background/Aims: Ligustrazine (LSZ) has been identified as an antitumor agent against some types of cancers. Nevertheless, its ability to inhibit growth, migration and invasion of medulloblastoma cells is still unclear. This study aimed to explore the effect of LSZ on Daoy cells. Methods: The effects of LSZ on viability, proliferation, apoptosis, migration, and invasion of Daoy cells were analyzed by CCK-8, BrdU, flow cytometry and Transwell assays, respectively. The effect of LSZ on miR-211 expression was analyzed by qRT-PCR. miR-211 inhibitor transfection was performed to suppress miR-211 expression. The effects of LSZ on apoptosis-related factors, MMP-2, MMP-9, and Vimentin (Vim), as well as main factors of PI3K/AKT and mTOR pathways were analyzed by Western blot. Results: LSZ inhibited viability but promoted apoptosis of Daoy cells. Additionally, the proliferative, migratory and invasive abilities of Daoy cells were decreased by LSZ. Meanwhile, LSZ promoted the activations of Caspase-3 and Caspase-9, increased Bax level, decreased Bcl-2 level, as well as inhibited the expressions of MMP-2, MMP-9 and Vim. Additionally, we found that LSZ enhanced miR-211 expression and exerted its anti-medulloblastoma effect by up-regulation of miR-211. Furthermore, LSZ inhibited PI3K/AKT and mTOR signaling pathways by up-regulating miR-211. Conclusion: LSZ suppressed medulloblastoma Daoy cells by up-regulating miR-211 and further modulating the activations of PI3K/AKT and mTOR signaling pathways.

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“…Some studies have demonstrated that miR211 holds a significant position in the development and progression of cancers, and even other diseases [10–12, 38]. Recently, some researchers found that miR211 inhibited invasion and epithelial-to-mesenchymal transition of cervical cancer cells via targeting MUC4 [10].…”

Section: Discussionmentioning

confidence: 99%

microRNA-211 regulates cell proliferation, apoptosis and migration/invasion in human osteosarcoma via targeting EZRIN

Pei

Yao

et al. 2019

Cell Mol Biol Lett

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Background In recent years, microRNA-211 (miR211) has been considered as a tumor suppressor in multiple malignancies. However, the function of miR211 in human osteosarcoma has not been explored intensively so far. In this study, the relationship between miR211 and EZRIN was analyzed in human osteosarcoma. Methods The expression levels of miR211 and EZRIN were measured in both human osteosarcoma cells and tissues. The direct regulatory relationship between miR211 and EZRIN was evaluated using dual-luciferase assay. The effect of miR211 and EZRIN overexpression on cell proliferation, migration/invasion, and apoptosis was detected. Results The expression of miR211 was obviously lower in osteosarcoma tissues than paracancerous tissues. EZRIN was identified as the direct target of miR211, and up-regulation of miR211 increased the percentage of cell apoptosis, and suppressed cell proliferation as well as cell migration/invasion via directly regulating EZRIN. Conclusions Our study indicated that miR211 has an important role in the development and progress of osteosarcoma, and it might become a novel target in the diagnosis and treatment of human osteosarcoma. Electronic supplementary material The online version of this article (10.1186/s11658-019-0173-x) contains supplementary material, which is available to authorized users.

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Overexpression miR‐211‐5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11

Abstract: MiR-211-5p affected the viability, proliferation and invasion of TC by negatively regulating SOX11 expression.

Cited by 42 publications

References 46 publications

RETRACTED: The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis

RETRACTED: The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis

Ligustrazine Inhibits Growth, Migration and Invasion of Medulloblastoma Daoy Cells by Up-Regulation of miR-211

microRNA-211 regulates cell proliferation, apoptosis and migration/invasion in human osteosarcoma via targeting EZRIN

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