2010
DOI: 10.1203/pdr.0b013e3181bf572b
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Overexpression of Allograft Inflammatory Factor-1 Promotes the Proliferation and Migration of Human Endothelial Cells (HUV-EC-C) Probably by Up-Regulation of Basic Fibroblast Growth Factor

Abstract: Our previous study demonstrated that allograft inflammatory factor-1 (AIF-1) is present in the vessels of infantile hemangiomas but neither in the vessels of vascular malformations, pyogenic granulomas, normal skin, placental tissues nor in the neovessels of squamous cell carcinomas of the tongue. The purpose of this study was to explore the impact of AIF-1 alterations on endothelial cells (EC). Stable introduction of AIF-1 to the human umbilical vein EC line (HUV-EC-C) in vitro revealed that AIF-1 enhances th… Show more

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Cited by 25 publications
(19 citation statements)
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“… 35 , 36 , 37 , 38 , 39 , 40 Upregulation in microglia activity and expression can lead to increased production and release of pro-inflammatory cytokines 46 , 66 , 83 from microglia, which promotes endothelial cell proliferation. 84 , 85 Iba1 is constitutively expressed in the microglia, 86 however increased number of Iba1-positive microglial has been observed in brain regions following trauma, likely as both a response to inflammation, but also as a triggering event in inflammation via the release of cytokines from active Iba1-positive microglia. 35 , 36 , 37 , 38 , 39 , 40 This increase in microglia has been associated with an increase in microglial proliferation and recruitment towards areas of inflammation.…”
Section: Discussionmentioning
confidence: 99%
“… 35 , 36 , 37 , 38 , 39 , 40 Upregulation in microglia activity and expression can lead to increased production and release of pro-inflammatory cytokines 46 , 66 , 83 from microglia, which promotes endothelial cell proliferation. 84 , 85 Iba1 is constitutively expressed in the microglia, 86 however increased number of Iba1-positive microglial has been observed in brain regions following trauma, likely as both a response to inflammation, but also as a triggering event in inflammation via the release of cytokines from active Iba1-positive microglia. 35 , 36 , 37 , 38 , 39 , 40 This increase in microglia has been associated with an increase in microglial proliferation and recruitment towards areas of inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…In light of this observation, it is possible that the CR-induced inhibition of NF-κB expression inhibition could result in part from inhibition of AIF1 protein expression. Furthermore, the role of AIF1 in regulation of angiogenesis in certain tumors is evident [99]. The protein encoded by the AIF1 gene in humans is thought to be involved in the negative regulation of vascular smooth muscle cell growth, which could contribute to the anti-inflammatory response to vessel wall trauma.…”
Section: Discussionmentioning
confidence: 99%
“…An orthologue of the evolutionary conserved allograft in ammatory factor (AIF), which is a conserved protein typically expressed in phagocytes and granular leukocytes in both vertebrate and invertebrate. Functions demonstrated for AIF include macrophage activation, enhancement of cellular proliferation and of migration in mammalian and invertebrate cells [37][38][39][40][41]. AIF also plays a key role in the protective response by B. glabrata to invasion by schistosomes [8,9].…”
Section: Introductionmentioning
confidence: 99%