Overexpression of ARID4B predicts poor survival in patients with hepatocellular carcinoma

Wang, Rongchang; Yu, Zhenzhen; Liao, Chunlian; Wang, Qian; Huang, Xiaohui

doi:10.1016/j.humpath.2017.12.012

Cited by 14 publications

(13 citation statements)

References 22 publications

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“…However, ARID4B contains a Tudor domain and a chromo domain, and these domains may function as adaptors to assemble chromatin remodeling complexes 13,14 . Expression of ARID4B is elevated in many types of tumors 15–18 , and ARID4B promotes mammary tumor growth and metastasis 19 . Despite these early findings, the role of ARID4B in prostate cancer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

Young

Chen

et al. 2019

Nat Commun

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PTEN is frequently mutated in prostate cancer. The tumor suppressor function of PTEN is attributed to its lipid phosphatase activity that counters PI3K action. Here, we report a PTEN-ARID4B-PI3K axis in which PTEN inhibits expression of ARID4B, while ARID4B is a transcriptional activator of the PI3K subunit genes PIK3CA and PIK3R2 that are crucial for activation of the PI3K/AKT pathway. Reciprocal binding of ARID4B and histone H1 to the PIK3CA and PIK3R2 promoters modulates chromatin condensation, suggesting a mechanism by which ARID4B activates these promoters. Functional analyses reveals that ARID4B is required for prostate tumorigenesis when PTEN is deficient. The biological significance is further substantiated by the existence of a PTEN/ARID4B/PIK3CA three-gene signature that improves the predictive power for prostate cancer recurrence in patients. In summary, we identify ARID4B as a master regulator in the PTEN-PI3K pathway, thus providing a potential therapeutic target for prostate cancer carrying PTEN mutations.

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Section: Introductionmentioning

confidence: 99%

Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

Young

Chen

et al. 2019

Nat Commun

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“…The role of ARID1B in stem cell-like features was unclear in previous CHOL studies. However, evidence supports that ARID1A and ARID1B work together in DNA modulation, which might provide a basis for subsequent investigations of stemness regulation (34). On these grounds, the associations with stemness might not be direct intervention.…”

Section: Discussionmentioning

confidence: 96%

Expression Signature of the AT-Rich Interactive Domain Gene Family Identified in Digestive Cancer

Liu

Wang

et al. 2022

Front. Med.

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BackgroundThe AT-rich interactive domain (ARID) gene family of 15 proteins has an important role in development and proliferation. Gene expression alterations of the ARID family are correlated with the pathogenesis of digestive cancer, but systematic research has not been conducted.MethodsWe obtained transcriptome sequencing data, clinical characteristics and stemness indices of the seven main types of digestive cancer (cholangiocarcinoma, colon adenocarcinoma, oesophageal carcinoma, liver hepatocellular carcinoma, pancreatic adenocarcinoma, rectum adenocarcinoma and stomach adenocarcinoma) from public pan-cancer data to combine the analysis of the expression and prognostic signature of the ARID gene family. The stromal and immune scores for each sample were calculated to explore the correlations between the ARID gene family members and the tumour microenvironment.ResultsAfter screening, 1,920 digestive cancer samples were included in our study. ARID3C was expressed at low levels throughout the digestive cancer samples. The expression levels of ARID1A and JARID1C were relatively high, but there was striking heterogeneity across the different cancer types for specific family members. The survival analysis indicated that many genes were significantly related to the prognosis of patients with liver hepatocellular carcinoma. The stemness indices, stromal score, and immune score analysis showed that the expression of a single ARID gene had characteristic consistency in each tumour, but the levels among the different genes still varied.ConclusionOur systematic study of the ARID gene family and its association with the immune infiltrate, tumour microenvironment and outcomes of digestive cancer patients focus on the complex relations and indicate the need to study each ARID member as an individual in a specific cancer type.

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“…Compared to nearby normal liver tissues, ARID4B was shown to be strongly expressed in HCC tissues. A poor prognosis for HCC patients was indicated by high ARID4B expression, which was found to be associated with tumor-node-metastasis stages, Edmondson-Steiner grades, vascular invasion, and tumor size [ 31 ]. According to these findings, ARID members have the potential to be exploited as novel biomarkers for HCC diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Landscape of ARID Family Members and Their Association with Prognosis and Tumor Microenvironment in Hepatocellular Carcinoma

Sun

Cheng

2022

Journal of Immunology Research

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As one of the most lethal forms of cancers, hepatocellular carcinoma (HCC) claims many lives around the world, and it is especially common in China. The ARID family plays key roles in the pathogenesis and development of human cancers. The potential of several functional genes used as novel biomarkers has attracted more and more attention. However, the prognostic values of the ARID family in HCC patients are rarely known by people. In this study, we performed comprehensive analysis using TCGA datasets, finding that the expressions of ARID4B, ARID2, ARID3B, JARID2, ARID1A, ARID1B, and ARID3A were increased in HCC specimens compared to nontumor specimens, while the expressions of ARID4A and ARID3C were decreased in HCC specimens. According to the Pearson correlation data, the methylation levels of the majority of ARID members were negatively correlated. Upregulation of ARID3A, ARID5B, and ARID1A was related to a poor HCC outcome according to the data of multivariate assays. Then, we built a LASSO Cox regression model based on ARID3A, ARID5B, and ARID1A in HCC. Overall survival rates were considerably lower for those with high risk scores compared to those with low risk scores. Finally, we studied the associations between risk scores and several types of infiltrating immune cells. The data revealed that the risk score was positively related to the infiltration of CD8+ T cells, B cell, T cell CD8+, neutrophil, macrophage, and myeloid dendritic cell. This study conducted a thorough analysis of the ARID members, resulting in new insights for further examination of the ARID family members as prospective targets in the treatment of HCC.

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Overexpression of ARID4B predicts poor survival in patients with hepatocellular carcinoma

Cited by 14 publications

References 22 publications

Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

Expression Signature of the AT-Rich Interactive Domain Gene Family Identified in Digestive Cancer

Comprehensive Landscape of ARID Family Members and Their Association with Prognosis and Tumor Microenvironment in Hepatocellular Carcinoma

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