Overexpression of cdk4 and p16 in oral lichen planus supports the concept of premalignancy

Poomsawat, Sopee; Buajeeb, Waranun; Khovidhunkit, Siribang-on Piboonniyom; Punyasingh, Jirapa

doi:10.1111/j.1600-0714.2010.01001.x

Cited by 35 publications

(37 citation statements)

References 31 publications

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“…The debate on the allegedly potentially malignant character of oral lichen planus is going on already for several decades (18-23). In a seven-year follow-up study of 327 patients the annual maligant transformation rate amounted less than 0.5% (24).…”

Section: Oral Lichen Planusmentioning

confidence: 99%

Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

Waal

2014

Med Oral

148

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Leukoplakia is the most common potentially malignant disorder of the oral mucosa. The prevalence is approximately 1% while the annual malignant transformation ranges from 2% to 3%. At present, there are no reliable clinicopathological or molecular predicting factors of malignant transformation that can be used in an individual patient and such event can not truly be prevented. Furthermore, follow-up programs are of questionable value in this respect. Cessation of smoking habits may result in regression or even disappearance of the leukoplakia and will diminish the risk of cancer development either at the site of the leukoplakia or elsewhere in the mouth or the upper aerodigestive tract. The debate on the allegedly potentially malignant character of oral lichen planus is going on already for several decades. At present, there is a tendency to accept its potentially malignant behaviour, the annual malignant transformation rate amounting less than 0.5%. As in leukoplakia, there are no reliable predicting factors of malignant transformation that can be used in an individual patient and such event can not truly be prevented either. Follow-up visits, e.g twice a year, may be of some value. It is probably beyond the scope of most dentists to manage patients with these lesions in their own office. Timely referral to a specialist seems most appropriate, indeed. Key words:Oral potentially malignant disorders, oral leukoplakia, oral lichen planus.

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Section: Oral Lichen Planusmentioning

confidence: 99%

Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

Waal

2014

Med Oral

148

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“…In a similar hypothetical model, Poomsawat et al, considered their observations of increased p16 INK4A and cdk4 expression in OLP as evidence of a precancerous OLP process [33]. In a contradictory study, Montebugnoli et al did not find significant differences in p16 INK4A expression in OLP and nonspecific oral inflammation and interpreted the p16 INK4A expression only as a sign of inflammation [34].…”

Section: Cell Cycle Control In Oral Lichen Planusmentioning

confidence: 99%

Oral Lichen Planus as a Preneoplastic Inflammatory Model

Georgakopoulou

Achtari

Achtaris³

et al. 2012

Journal of Biomedicine and Biotechnology

100

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Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as “a potentially malignant disorder,” it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical studies. Over the past years, several amount of information has accumulated, mainly from molecular studies on the OLP malignant potential. This article is a critical review of whether OLP has a malignant potential and, therefore, represents a model of preneoplastic inflammation.

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“…In recent years, the application of biomarkers has contributed to objective evaluation of the stage of OLP, and to the prediction of the potential risk of malignant transformation (17). Thus, the improvement of the specificity and reliability of biomarkers remains the core task in this research field.…”

Section: Introductionmentioning

confidence: 99%

Expression of E-cadherin in oral lichen planus

2015

Experimental and Therapeutic Medicine

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Abstract. Oral lichen planus (OLP) is a common lesion of the oral mucosa that can progress to cancer. E-cadherin is involved in intercellular adherence and the pathogenesis, development and metastasis of tumors, and is considered to be an important indicator of tumor progression and prognosis. The aim of this study was to investigate the expression of E-cadherin in OLP in order to elucidate its role in the pathogenesis and malignant transformation of OLP and provide evidence to support the early diagnosis and treatment of OLP with malignant potential. OLP specimens (n=52) and samples of normal oral mucosa (n=41) as the control were collected. Immunohistochemical staining was conducted to reveal the expression of E-cadherin in the OLP samples and normal oral mucosa. It was observed that 25 of the 52 OLP specimens exhibited normal positive expression of E-cadherin and 27 exhibited abnormal positive expression, corresponding to an abnormal positive rate of 51.92%. In the normal oral mucosa group, 39 of the 41 cases exhibited normal positive expression and 2 exhibited abnormal positive expression. The abnormal positive rate in the normal oral mucosa was 4.88%, which was significantly lower than that in the OLP group. The significantly elevated rate of abnormal positive expression of E-cadherin in the OLP group indicates the involvement of E-cadherin in the malignant transformation of OLP and supports the malignant potential of OLP.

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Overexpression of cdk4 and p16 in oral lichen planus supports the concept of premalignancy

Abstract: Oral lichen planus demonstrated overexpression of cdk4 and p16, but not cdk6, suggesting that epithelial cells in OLP are in the hyperproliferative state and in cell arrest. Altered expression of cdk4 and p16 provides evidence of the malignant potential in OLP.

Cited by 35 publications

References 31 publications

Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

Oral Lichen Planus as a Preneoplastic Inflammatory Model

Expression of E-cadherin in oral lichen planus

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