Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation

Pandey, Manoj; Prakash, Om; Santhi, W.S.; Soumithran, C.S.; Pillai, Radhakrishna

doi:10.1016/j.ijom.2008.01.004

Cited by 51 publications

(61 citation statements)

References 39 publications

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“…Overexpression of COX2 has been found in human oral cancer and DMBA induced hamster cheek pouch tumor (29,30). In the present study, we found that in tumor samples of Hras128 rats treatment of 4NQO caused a marked increase in the levels of mRNA expression of cyclin D1 and COX2, when compared to the adjacent normal mucosa (Fig.…”

Section: Discussionsupporting

confidence: 66%

Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide

Naoi

Sunagawa²,

Yoshida³

et al. 2009

Oncol Rep

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Abstract. Transgenic rats carrying human c-Ha-ras protooncogene (Hras128 rats) have been shown to be highly susceptible to induction of tumors. We have found an early induction of tongue tumors in Hras128 rats treated with 4-nitroquinoline 1-oxide (4NQO). 4NQO was administered to the Hras128 and wild-type Sprague-Dawley (SD) rats for 4 and 8 weeks, respectively. The experiment was terminated at 14 (Hras128 rats) and 28 (SD rats) weeks. Either during or after treatment with 4NQO, dysplastic hyperplasia, papilloma and squamous cell carcinoma were found on the tongue of both Hras128 and wild-type rats, with a higher incidence and multiplicity in Hras128 rats. Treatment of the Hras128 rats with 4NQO significantly increased cell proliferation in the tumor compared to the control rats. In the tongue tumors of the Hras128 rats, there was a significant increase in the mRNA expression levels of cyclin D1 and COX2. To examine whether this experimental system is useful for screening of the candidate agents for cancer preventive effect, nimesulide, a selective COX2 inhibitor, was tested in the present model. Nimesulide significantly decreased total multiplicity of tongue lesions compared to the control rats. Treatment of Hras128 rats with nimesulide caused a significant decrease in the levels of mRNA expression of cyclin D1 and COX2 in the tumor. Therefore, the current 4NQO-induced Hras128 rat tongue carcinogenesis model provides a simple and rapid system for investigating carcinogenesis process and evaluating the effect of possible cancer preventive agents for human tongue cancer.

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Section: Discussionsupporting

confidence: 66%

Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide

Naoi

Sunagawa²,

Yoshida³

et al. 2009

Oncol Rep

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“…14 Pendi et al showed a significant higher exposure of COX2 gene in oral cancer patients compared to both normal controls and premalignant lesions. 9 They also found a higher exposure in premalignant patients compared to normal controls. We showed a significant higher expression of COX2 in SCC lesions compared to leukoplakias and normal controls.…”

Section: Discussionmentioning

confidence: 93%

“…This result was in agreement with result of Kawata and Pandy. 8,9 Kawata showed that expression of COX2 in welldifferentiated head and neck SCC was stronger than poorly differentiated SCC. 8 Kyzas showed a relation between COX2 expression and lymph node metastases at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 COX2 can increase prostaglandin synthesis in many malignant cells including esophagus, colon, lung and prostate. [7][8][9] This increase can drive tumor extention by angiogenesis and cell proliferation, modulating inflammatory and immune responses and inhibiting apoptosis. 7,[9][10][11][12] Lio et al showed that aspirin reduced the in vitro and in vivo proliferation of esophageal cancer cells and induced apoptosis , in a dose dependent manner.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] This increase can drive tumor extention by angiogenesis and cell proliferation, modulating inflammatory and immune responses and inhibiting apoptosis. 7,[9][10][11][12] Lio et al showed that aspirin reduced the in vitro and in vivo proliferation of esophageal cancer cells and induced apoptosis , in a dose dependent manner. 6 Goulart Filho et al showed that COX2 expression (COX2-E) was significantly higher in oral SCC than normal epithelium but there were no significant differences in COX2-E between high and low grade tumors.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of COX2 Expression between Oral Squamous Cell Carcinoma, Leukoplakia and Normal Mucosa

Amirchaghmaghi

Mohtasham²,

Mozaffari³

2012

The Journal of Contemporary Dental Practice

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Aim:To compare cyclooxygenase 2 expression (COX2-E) between normal, oral leukoplakia lesions and different grades of oral squamous cell carcinoma (SCC). Materials and methods:Around 90 paraffin embedded blocks consisting of 45 SCC, 15 leukoplakia and 17 controls were selected for immunohistochemistry (IHC) for detection of COX2-E. COX2-E was divided in four grades, as A (0-10%), B (11-40%), C (41-70%) and D (> 70%) cellularity.Results: Mean age of the patients was 55.17 ± 18.41

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Association of Physical Activity by Type and Intensity With Digestive System Cancer Risk

et al. 2016

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Importance Accumulating evidence indicates that common carcinogenic pathways may underlie digestive system cancers. Physical activity may influence these pathways, yet no previous study has evaluated the role of physical activity in overall digestive system cancer risk. Objective To examine the association between physical activity and digestive system cancer risk, accounting for amount, type (aerobic versus resistance), and intensity of physical activity. Design A prospective cohort study followed from 1986 to 2012. Setting Male health professionals living in the general community in the US Participants Eligible participants were 40 years or older, were free of cancer, and reported physical activity. Out of 51,529 individuals, 43,479 were followed-up, with follow-up rates exceeding 90% in each 2-year cycle. Exposures The amount of total physical activity expressed in metabolic equivalent of task [MET]-hours/week Main Outcomes and Measures Incident cancer of the digestive system encompassing the digestive tract (mouth, throat, esophagus, stomach, small intestine, and colorectum) and digestive accessory organs (pancreas, gallbladder, and liver). Results Over 686,924 person-years, we documented 1,370 incident digestive system cancers. Higher levels of physical activity were associated with lower digestive system cancer risk (hazard ratio [HR], 0.74 for 63+ versus ≤8.9 MET-hours/week; 95% confidence interval [CI], 0.59-0.93; P for trend, .003). The inverse association was more evident with digestive tract cancers (HR, 0.66 for 63+ versus ≤8.9 MET-hours/week; 95% CI, 0.51-0.87) than with digestive accessary organ cancers. Aerobic exercise was particularly beneficial against digestive system cancers, with the optimal benefit observed at approximately 30 MET-hours/week (HR, 0.68; 95% CI, 0.56-0.83; Pnon-linearity, 0.02). Moreover, as long as the same level of MET-hour score was achieved from aerobic exercise, the magnitude of risk reduction was similar regardless of intensity of aerobic exercise. Conclusion and Relevance Physical activity, as indicated by MET-hours/week, was inversely associated with the risk of digestive system cancers, particularly digestive tract cancers, in men. The optimal benefit was observed through aerobic exercise of any intensity at the equivalent of energy expenditure of approximately 10 hours/week of walking at average pace. Future studies are warranted to confirm our findings and to translate them into clinical and public health recommendation.

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Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation

Cited by 51 publications

References 39 publications

Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide

Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide

Comparison of COX2 Expression between Oral Squamous Cell Carcinoma, Leukoplakia and Normal Mucosa

Association of Physical Activity by Type and Intensity With Digestive System Cancer Risk

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