Overexpression of cytokeratin 17 protein in oral squamous cell carcinoma <i>in vitro</i> and <i>in vivo</i>

Kj, Wei; Zhang, L; Yang, X; Lp, Zhong; Xj, Zhou; Pan, Hongyu; Li, Jian; Chen, WT; Zy, Zhang

doi:10.1111/j.1601-0825.2008.01501.x

Cited by 45 publications

(47 citation statements)

References 22 publications

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“…These results are consistent with the report of Wei et al 12) . This cytokeratin may also be used in the diagnosis of the presence or absence of epithelial dysplasia, or cancer.…”

Section: Discussionsupporting

confidence: 84%

“…Epithelial dysplasia occurring on the tongue is most commonly presented and diagnosed as leukoplakia, and reports have indicated that several percents of leukoplakia undergo malignant changes 7,8) . Leukoplakia is a clinical diagnostic term, (2):123-130, 2010 reported [9][10][11][12][13] . However, the application of a combination of several immunohistochemical stains to diagnosis is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Study of Differential Expressions of Cytokeratin-13, -14, -17 and p53 in Epithelial Dysplasia and Carcinoma of the Tongue

Okada

Moride

2010

J. Hard Tissue Biology.

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In cancers of the oral cavity, high histological malignancy grade is associated with higher risk of cervical lymph nodes, lung and bone metastases, which have great impact on the prognosis. Furthermore, early detection of these cancers is desirable so that treatment can aim at conserving oral functions and improving prognosis. It is known that several percent of leukoplakia that develop in the tongue become cancerous. Leukoplakia is a clinical diagnostic term, and histopathologically most cases show hyperkeratosis with epithelial dysplasia or hyperkeratosis without epithelial dysplasia. On the other hand, difficulties in histopathological diagnosis of severe epithelial dysplasia and carcinoma in situ are often encountered. In recent years, immunohistochemical staining of cytokeratins (CK), p53 and Ki-67 for precancerous lesions and squamous cell carcinoma (SCC) of the oral cavity has been reported. However, few reports have applied a combination of several immunohistochemical stainings to diagnosis. In the present study, with the objective to achieve a higher precision in histopathological diagnosis, we conducted and compared the immunohistochemical stainings of CK13, CK17, CK14 and p53 in 10 cases each of hyperkeratosis without epithelial dysplasia, hyperkeratosis with epithelial dysplasia, carcinoma in situ, and SCC in the tongue. The following results were obtained. CK13 was positive in all 10 cases of hyperkeratosis without epithelial dysplasia, and negative in all cases of hyperkeratosis with epithelial dysplasia, carcinoma in situ, and SCC. CK17 was negative in all 10 cases of hyperkeratosis without epithelial dysplasia, and was positive in all 10 cases of hyperkeratosis with epithelial dysplasia as well as 10 cases of carcinoma in situ and 9 of 10 cases of SCC. CK14 was negative or positive only in the basal cell layer or a few rows of cells in spinous layer adjacent to the basal cell layer in cases of hyperkeratosis without epithelial dysplasia, but was positive in all the epithelial layers in all 10 cases of hyperkeratosis with epithelial dysplasia, and also positive in the tumor in all 10 cases each of carcinoma in situ and SCC. For p53, positive reaction was observed in some cells of the basal cell layer in 2 of 10 cases of hyperkeratosis without epithelial dysplasia, while high positive rates were found in hyperkeratosis with epithelial dysplasia (10 of 10 cases) and SCC (9 of 10 cases). On the other hand, only 5 of 10 cases of carcinoma in situ were positive for p53. In conclusion, although the histopathological diagnosis of epithelial dysplasia and carcinoma in situ is based on hematoxylin-eosin stained sections, immunostaining and evaluation of CK13, CK17, CK14 and p53 are useful as an adjunct to histopathological diagnosis.

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“…These results are consistent with the report of Wei et al 12) . This cytokeratin may also be used in the diagnosis of the presence or absence of epithelial dysplasia, or cancer.…”

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Study of Differential Expressions of Cytokeratin-13, -14, -17 and p53 in Epithelial Dysplasia and Carcinoma of the Tongue

Okada

Moride

2010

J. Hard Tissue Biology.

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“…2). After quantitative analysis, we confirmed about known markers, K 13, 17 and CD98 8,20,21 and validated whether this experiment reflected each lesion. In addition, we identifi ed K6hf as a candidate marker of OSCC (Table 1).…”

Section: Protein Identifi Cation By Lc/ms/msmentioning

confidence: 67%

Expression of Keratin 75 (K6hf) in Oral Squamous Cell Carcinoma

Obara

Yamamoto

Hayashi

et al. 2011

DMR, Dental Med Res

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“…W trakcie rozwoju nowotworu ekspresja keratyn jest utrzymywana, ale zmianie ulega wzór ich ekspresji, dlatego są one wykorzystywane jako markery zmian nowotworowych. W badaniach wykazano, że w obrę-bie guzów jamy ustnej zwiększonej ekspresji ulegają keratyny K8/K18, K17 i K14 (2,6,12,14,18,30,48,52), natomiast obniżoną aktywność wykazują K4, K5, K13 i K19 (2,6,18,19,25,30,36). W jednym z badań analizowano ekspresję KRT76 w błonie śluzowej policzków chomika.…”

Section: Markery Będące Wskaźnikami Procesu Kancerogenezyunclassified

Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research

Bryja

Dyszkiewicz-Konwińska

Budna

et al. 2017

Medycyna Weterynaryjna

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SummaryNeoplastic diseases are a challenge to modern medicine. The understanding of histological, molecular and genetic transformation leading to cancer is essential in establishing methods for earlier diagnosis and better treatment of oral cavity cancer, not only in humans but also in animals -in particular, in dogs and cats, which develop oral cancer spontaneously. There are several methods of cancer modeling that expand research capabilities. The following overview discusses different methods of inducing carcinogenesis in animals and presents animal models used in the study of carcinogenesis. Publications reviewed in the paper discuss markers used in the diagnosis of oral cancer and describe the concept of cancer stem cells.

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Overexpression of cytokeratin 17 protein in oral squamous cell carcinoma in vitro and in vivo

Abstract: Increased CK17 expression may play an important role in the carcinogenesis progression of OSCC; however, further studies on the molecular function of CK17 are encouraged to clear the precise mechanism of CK17 in OSCC.

Cited by 45 publications

References 22 publications

Immunohistochemical Study of Differential Expressions of Cytokeratin-13, -14, -17 and p53 in Epithelial Dysplasia and Carcinoma of the Tongue

Immunohistochemical Study of Differential Expressions of Cytokeratin-13, -14, -17 and p53 in Epithelial Dysplasia and Carcinoma of the Tongue

Expression of Keratin 75 (K6hf) in Oral Squamous Cell Carcinoma

Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research

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