Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer

Tang, Xiao Yan; Umemura, Shinobu; Tsukamoto, Hideo; Kumaki, Nobue; Tokuda, Yutaka; Osamura, R. Yoshiyuki

doi:10.1016/j.prp.2009.06.010

Cited by 35 publications

(27 citation statements)

References 15 publications

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“…Tang et al showed a high level of phosphorylated stst5 in FABP7 transgenic mice [32]; however, in our study, we found a significant negative association between overexpression of nuclear FABP7 and PIASc. In contrast, PIASc was associated with increased survival when co-expressed with FABP7 ?…”

Section: Discussioncontrasting

confidence: 96%

“…In our study, we defined BLBC on the basis of positive expression of any of the basal CKs (CK5, CK14 and CK17) in addition to negativity of both ER and HER2. Higher expression FABP7 has been shown in BLBC, at both the protein and DNA level [16,28,32], and is a candidate for further investigation as a biomarker of BLBC [16]. FABP7 is a member of lipid-binding protein family (LBP), which are involved in transportation and storage of fatty acids for metabolism [33].…”

Section: Discussionmentioning

confidence: 99%

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Fatty acid binding protein 7 expression and its sub-cellular localization in breast cancer

Alshareeda

Rakha

Nolan

et al. 2012

Breast Cancer Res Treat

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FABP7 is a member of the multi-gene fatty acid binding protein family. It is expressed in the mammary gland and has been shown to function as inhibitor of proliferation of breast tumour cells and to promote differentiation through the JAK/Stat pathway. Cytoplasmic FABP7 expression has been shown to be associated with a favourable prognosis of basal-like breast cancer. In other tissues, varying sub-cellular localization of FABP7 between the nucleus and cytoplasm has been observed. Tissue microarray preparations of well-characterized series of 1,249 unselected and 245 ER-negative invasive breast cancers with a long-term follow-up were investigated in this study to assess the biological and clinical significance of FABP7 sub-cellular localization using immunohistochemistry. Both nuclear and cytoplasmic FABP7 were observed. Nuclear FABP7 was associated with high histologic grade, mitotic frequency, pleomorphism and stage, in addition to basal phenotype (BP) and triple-negative (TN) phenotype. Nuclear FABP7 expression showed an association with expression of markers associated with proliferation and cell-cycle control including Ki67, p53 and p21; however, cytoplasmic FABP7 was associated only with Ki67 and P53 (P = 0.001, < 0.001 respectively). Interestingly, in multivariate analysis, nuclear FABP7 expression in BP was significantly associated with longer DFI (P = 0.025) independent of cytoplasmic expression. Tumours with only nuclear positive FABP7 expression had significantly better prognosis than those with only cytoplasmic expression. This is the first study elucidating the sub-cellular localization of FABP7 in a large series of breast cancer cases. Our observations demonstrate the considerable heterogeneity in expression patterns of FABP7 within breast cancer that relates to differences in biological behaviour especially in basal-like breast cancer. Further investigation of the biology of FABP7 in breast cancer is warranted.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Fatty acid binding protein 7 expression and its sub-cellular localization in breast cancer

Alshareeda

Rakha

Nolan

et al. 2012

Breast Cancer Res Treat

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“…have demonstrated significant correlations between FABP7 immunoreactivity and absence of ER/PR expression in breast cancer. 23,51 One group suggested that elevated levels of FABP7 may underlie high histological grade and poor prognosis in basal-like breast tumors, 51 but the other group observed a better prognosis in FABP7-positive basal-like breast tumors. 23 These data highlight the need for further studies to clarify the various roles of FABPs and their ligands in breast cancer formation and progression.…”

Section: Discussionmentioning

confidence: 99%

Association of FABP5 Expression With Poor Survival in Triple-Negative Breast Cancer

Liu

Graham

Glubrecht

et al. 2011

The American Journal of Pathology

143

124

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Recent studies using animal models suggest that expression of FABP5 drives the stimulation of cell growth observed in estrogen receptor (ER)-negative breast cancer cells on exposure to retinoic acid (RA). The purpose of this study was to investigate the clinicopathological significance of FABP5 in breast cancer and to evaluate FABP5 as a prognostic marker and a possible novel therapeutic target in breast cancer. Gene expression microarray analysis revealed a significant correlation between elevated FABP5 RNA levels and ER/ progesterone receptor (PR)-negative status, high tumor grade, and poor prognosis. Tissue microarray analysis demonstrated similar correlations with cytoplasmic FABP5 protein. Based on multivariate proportional regression analysis, cytoplasmic FABP5 is a significant and independent prognostic marker of overall survival and recurrence-free survival in breast cancer. The effects of FABP5 on tumor growth appear to be mediated primarily through cytoplasmic FABP, because no correlation was found between nuclear FABP5 and ER/PRnegative status, recurrence, and survival. FABP5 knockdown in breast cancer cell lines demonstrates a correlation between FABP5 levels and growth response to RA. We propose a model whereby growth-promoting FABP5 competes with growth-inhibiting CRABP2 for RA, with retention of RA in the cytoplasm by FABP5 preventing the inhibition of tumor growth. (Am J Pathol

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“…FABPs are all approximately 15kDa in size and have a β-barrel tertiary structure that forms a cavity where FAs bind; additionally FABPs also have a helix-loop-helix motif which is thought to be the point of entry for the FAs [4,5]. Gene expression analysis and immunohistochemical (IHC) studies have found that FABP7 is over expressed in basal like (BLBC) and triple negative (TN) breast cancer, however whether it is an indicator of good or poor prognosis is of debate [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

A Strategic Approach for the Visualisation of the Low Abundance Protein Fatty Acid Binding Protein 7

Dean¹,

Perks²,

Rhodes³

et al. 2015

Am. J. Biomed. Sci.

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Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer

Cited by 35 publications

References 15 publications

Fatty acid binding protein 7 expression and its sub-cellular localization in breast cancer

Fatty acid binding protein 7 expression and its sub-cellular localization in breast cancer

Association of FABP5 Expression With Poor Survival in Triple-Negative Breast Cancer

A Strategic Approach for the Visualisation of the Low Abundance Protein Fatty Acid Binding Protein 7

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