Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity

Kunkel, Martin; Moergel, Maximilian; Stockinger, Marcus; Jeong, Jong‐Hyeon; Fritz, Gerhardt; Lehr, Hans‐Anton; Whiteside, Theresa L.

doi:10.1016/j.oraloncology.2006.10.009

Cited by 92 publications

(90 citation statements)

References 27 publications

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“…A few studies have suggested that the varying patterns of GLUT-1 expression could have prognostic value, such as the study of Smeland et al on sarcomas (21). However, some other studies have reached contrary conclusions (22). Most of our present cases showed membranous expression, whereas a few had a combination of both membranous and cytoplasmic staining.…”

Section: Discussioncontrasting

confidence: 48%

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

Angadi¹,

Angadi²

2015

Journal of Oral Science

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Section: Discussioncontrasting

confidence: 48%

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

Angadi¹,

Angadi²

2015

Journal of Oral Science

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“…Increasing glycolytic metabolism has been shown to depend above all on the glycolytic phenotype, overexpression of glucose transporters, particularly of GLUT-1, in a variety of tumor types, including OSCC (26). In addition, overexpression of GLUT-1 is detected at an early stage after cancer transformation (27).…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, it was suggested that the predictive factors of the histological effect following neoadjuvant chemoradiotherapy are not determined by immunostaining score alone, and the histological effects are related to the location and size of the tumor and other clinical and morphological factors (1). On the other hand, HIF-1· and GLUT-1 are negative biomarkers of prognosis and risk factors of recurrence in malignant tumors including OSCC (26) and NSCLS (24). Hypoxic cancer cells undergo a series of genetic and metabolic alterations that allow them, not only to survive, but also to become more resistant to chemotherapy and radiotherapy via the HIF-1· pathway (12,13).…”

Section: Discussionmentioning

confidence: 99%

SUVmax of FDG-PET correlates with the effects of neoadjuvant chemoradiotherapy for oral squamous cell carcinoma

Miyawaki

Ikeda²,

Hara³

et al. 2010

Oncol Rep

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Abstract. The aim of this study was to analyze the relationship between the maximum standardized uptake value (SUVmax) of 18F-fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) and the effects of neoadjuvant chemoradiotherapy in oral squamous cell carcinoma (OSCC), and to identify the possible biological background of this association. Thirty-seven patients with OSCC, who underwent preoperative FDG-PET followed by cancer treatment with neoadjuvant chemoradiotherapy, were enrolled in this study. The various histological effects following neoadjuvant chemoradiotherapy were compared to the SUVmax in the primary OSCC. These effects were also compared to the immunohistochemical staining score of hypoxia-inducible factor-1· (HIF-1·), glucose membrane transporter (GLUT)-1 and vascular endothelial growth factor (VEGF) in the biopsy specimen. Furthermore, we analyzed the chemosensitivity of KB-3-1 cells to cisplatin under hypoxic conditions using the MTT assay. A negative correlation was observed between the SUVmax and the histological effects following neoadjuvant chemoradiotherapy (p<0.01). The SUVmax was also correlated with the staining score of HIF-1· (p<0.03), but not with GLUT-1 and VEGF. The mean staining score of HIF-1· in the highly effective group was 2.7±1.1, which was significantly lower than that (3.7±0.9) of the poorly effective group (p<0.05). The cell chemosensitivity assay revealed chemoresistant effects under a hypoxic condition in OSCC. In conclusion, the SUVmax is correlated with the effectiveness of neoadjuvant chemoradiotherapy in OSCC.Our clinical and experimental analyses further suggest a possible association of the upregulation of HIF-1· with chemoradiosensitivity in SCC cells.

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“…In addition to providing prognostic information, data suggest that modulation of radiation resistance by inhibition of glucose transport in the tumour may be a novel strategy for improving the effectiveness of radiotherapy in tumours. 23 The advantage of using intrinsic markers of hypoxia, such as Glut-1, is that the approach is simple and quick, and could potentially be applied to a wide variety of solid tumour types.…”

Section: Discussionmentioning

confidence: 99%

Comparison between hypoxic markers pimonidazole and glucose transporter 1 (Glut-1) in murine fibrosarcoma tumours after electrochemotherapy

Cör

Čemažar²,

Plazar³

et al. 2009

Radiology and Oncology

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Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity

Cited by 92 publications

References 27 publications

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

SUVmax of FDG-PET correlates with the effects of neoadjuvant chemoradiotherapy for oral squamous cell carcinoma

Comparison between hypoxic markers pimonidazole and glucose transporter 1 (Glut-1) in murine fibrosarcoma tumours after electrochemotherapy

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