2024
DOI: 10.1186/s44342-024-00010-7
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Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Jieun Lee,
Jung-Ah Hwang,
Seung-Hyun Hong
et al.

Abstract: Here, we investigated that the heat shock protein 47 (HSP47) plays a crucial role in the progression of gastric cancer (GC). We analyzed HSP47 gene expression in GC cell lines and patient tissues. The HSP47 mRNA and protein expression levels were significantly higher in GC cell lines and tumor tissues compared to normal gastric mucosa. Using siRNA to silence the expression of HSP47 in GC cells resulted in a significant reduction in their proliferation, wound healing, migration, and invasion capacities. Additio… Show more

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